Key Features

  • Offers detailed discussions on today’s technologies to help you select the best test for case evaluation.
  • Presents recognized molecular pathologists who convey the most current information, keeping you on the cusp of your field.
  • Features nearly 250 full-color illustrations that present important pathologic features, enabling you to form a differential diagnosis and compare your findings with actual cases.
  • Uses a consistent, user-friendly format, including at-a-glance boxes and tables for easy reference.

Table of Contents

SECTION I. MOLECULAR PRINCIPLES

Chapter 1 Molecular Biology Basics for the Pathologist, Ilka Warshawsky

Chapter 2 Quality Assurance of Molecular Assays, Wayne W. Grody

SECTION II. MOLECULAR TOOLS AND TECHNIQUES

Chapter 3 Overview of Molecular Diagnostic Techniques and Instrumentation, Daniel H. Farkas and Carol A. Holland

Chapter 4 Conventional and Real Time Polymerase Chain Reaction (PCR), Aaron Bossler and Vivianna Van Deerlin

Chapter 5 Loss of Heterozygosity, Jennifer L. Hunt

Chapter 6 Direct Genome Sequencing in Diagnostic Pathology, Gurunathan Murugesan and Gary W. Procop

Chapter 7 Array-Based Comparative Genomic Hybridization in the Analysis of Genomic Alterations in Human Disease, Marek Skacel, Ana Ambu Siva, and Raymond R. Tubbs

Chapter 8 Expression Arrays: Discovery and Validation, Neal Poulin and Torsten O. Nielsen

Chapter 9 Epigenetics: DNA Hypermethylation in Cancer, Bin Yang

Chapter 10 Tissue Microarrays, Ziad Peerwani

Chapter 11 Fluorescence in Situ Hybridization, James R. Cook

Chapter 12 Bright Field in Situ Hybridization, Ricardo V. Lloyd, Xiang Qian, and Long Jin

Chapter 13 Immunoglobulin and T-Cell Receptor Gene Rearrangement, Margaret L. Gulley

Chapter 14 Monitoring of Minimal Residual Hematologic Disease, Cuihong Wei, Jeffrey H. Lipton, and Suzanne Kamel-Reid

Chapter 15 Molecular Detection of Circulating Tumor Cells, Karen L. Kaul

Chapter 16 Intraoperative Molecular Staging Using Real-Time PCR, Tony E. Godfrey

SECTION III. DIAGNOSTIC MOLECULAR PATHOLOGY APPLICATIONS

Chapter 17, Molecular Cytopathology, Karen S. Gustafson and Douglas P. Clark

Chapter 18 Molecular Diagnosis of Infectious Agents in Tissue, Randall T. Hayden and Gary W. Procop

Chapter 19 Molecular Neuropathology, Richard Prayson

Chapter 20 Molecular Pathology of the Cardiovascular S

Details

No. of pages:
452
Language:
English
Copyright:
© 2009
Published:
Imprint:
Churchill Livingstone
Print ISBN:
9780443069017
Electronic ISBN:
9781437719482