Description

Caveolae (latin for little caves) are small structures found at the surface of cells. They are responsible for the regulation of important metabolic pathway. As a consequence, they may play a critical role in several human diseases such as atherosclerosis, cancer, diabetes, and muscular dystrophies. This book analyzes the role and function of caveolae in these aspects and serves as the first textbook currently available on caveolae/caveolin.

Readership

Cell biologists, pharmaceutical researchers, and graduate level and medical students

Table of Contents

Section 1: Caveolae organization and role in lipid cholesterol metabolism. Lipid rafts and caveolae organization. Caveolae and the regulation of cellular cholesterol homeostasis. Section 2: Caveolae and the regulation of endocytosis. The Caveolae Internalization Machinery. Lipid raft mediated entry of bacteria into host cells. Section 3: Examples of the role of caveolins in cell signaling. The caveolin interaction with the endothelial nitric oxide synthase (eNOS). Caveolae and Estrogen Receptor Signaling. eNOS regulation by sphingosine 1-phosphate and caveolin. Insulin signaling and caveolae. Section 4: Caveolae and pathologies. Caveolin-3, Caveolae, and Hereditary Muscle Diseases. Caveolae and Caveolins in the Vascular System. Caveolin Proteins in Cardio-pulmonary Disease and Lung Cancers.

Details

No. of pages:
264
Language:
English
Copyright:
© 2005
Published:
Imprint:
Elsevier Science
eBook ISBN:
9780080458601
Print ISBN:
9780444515001
Print ISBN:
9780444560933

About the editor

Edward Bittar

Affiliations and Expertise

Department of Physiology, University of Wisconsin Medical School, Madison, USA

Reviews

Caveolae (latin for little caves) are small structures found at the surface of cells. They are responsible for the regulation of important metabolic pathway. As a consequence, they may play a critical role in several human diseases such as atherosclerosis, cancer, diabetes, and muscular dystrophies. This book analyzes the role and function of caveolae in these aspects and serves as the first textbook currently available on caveolae/caveolin.