Section 1: Caveolae organization and role in lipid cholesterol metabolism.
Lipid rafts and caveolae organization.
Caveolae and the regulation of cellular cholesterol homeostasis.
Section 2: Caveolae and the regulation of endocytosis.
The Caveolae Internalization Machinery.
Lipid raft mediated entry of bacteria into host cells.
Section 3: Examples of the role of caveolins in cell signaling.
The caveolin interaction with the endothelial nitric oxide synthase (eNOS).
Caveolae and Estrogen Receptor Signaling.
eNOS regulation by sphingosine 1-phosphate and caveolin.
Insulin signaling and caveolae.
Section 4: Caveolae and pathologies.
Caveolin-3, Caveolae, and Hereditary Muscle Diseases.
Caveolae and Caveolins in the Vascular System.
Caveolin Proteins in Cardio-pulmonary Disease and Lung Cancers.