Catecholamines and Schizophrenia

Catecholamines and Schizophrenia

1st Edition - January 1, 1975

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  • Editors: Steven W. Matthysse, Seymour S. Kety
  • eBook ISBN: 9781483159577

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Catecholamines and Schizophrenia reviews research linking catecholamines to schizophrenia. Topics include the relationship between stereotyped behavior and amphetamine psychosis, between antipsychotic drugs and catecholamine synapses, and between biogenic amines and behavior. The chemical neuropathology of schizophrenia, enzymology and regulation of catecholamine enzymes, and advances in histochemical technologies used in neurochemical pathology are also covered. This book consists of 47 chapters organized into six sections. After giving an overview of the pharmacology and physiology of stereotyped behavior, this book discusses the behavioral and biochemical aspects of amphetamine psychosis; stereoselective features of catecholamine disposition and their behavioral implications; and the effects of amphetamines on catecholamine metabolism. A two-factor theory of schizophrenia is also presented. The chapters that follow focus on the role of monoamine oxidase in schizophrenia and other behavioral disorders; the chemical pathology of schizophrenia; genetic control of biogenic amines; and dopamine-beta-hydroxylase. This book will be of value to students, researchers, and practitioners in fields ranging from neuropharmacology and physiology to biology, biochemistry, psychiatry, and psychology.

Table of Contents

  • I. Stereotyped Behavior and Amphetamine Psychosis


    Pharmacology and Physiology of Stereotyped Behavior


    Amphetamine Phychosis: Behavioral and Biochemical Aspects

    A Two Factor Theory of Schizophrenia

    Stereoselective Features of Catecholamine Disposition and Their Behavioral Implications

    Effects of Amphetamines on the Metabolism of Catecholamines in the Rat Brain

    A Mass Fragmentographic Study of Amphetamine and Metabolites in rat Brain


    II. Antipsychotic Drugs and Catecholamine Synapses

    Antipsychotic Drugs and Catecholamine Synapses

    Dose Equivalence of the Antipsychotic Drugs

    Brief Communications:

    Catecholamines and Antipsychotic Drugs in Periodic Catatonia

    A Pilot Study of Pimozide in Schizophrenia

    Dopaminergic Blocking Effects of Antipsychotic Drugs

    Mass Fragmentometric Determination of Homovanillic Acid in Lumbar Cerebrospinal Fluid of Schizophrenic Patients during Treatment with Antipsychotic Drugs

    New Developments in the Study of the Mechanism of Action of Neuroleptics and Amphetamine

    Biochemical Characterization of the Dopamine Receptor in the Mammalian Caudate Nucleus

    Antischizophrenic Drugs: Affinity for Muscarinic Cholinergic Receptor Sites in the Brain Predicts Extrapyramidal Effects

    Antipsychotic Drugs and Catecholamine Synapses. Summary of the Session


    Dopamine and the Pharmacology of Schizophrenia: The State of the Evidence

    III. Biogenic Amines and Behavior

    Self-stimulation Reward Pathways: Norepinephrine vs Dopamine

    Relationship of Biogenic Amines to Behavior

    Role of Dopamine and Norepinephrine in the Chemistry of Reward

    Consideration of some Problems Encountered in Relating Specific Neurotransmitters to Specific Behaviors or Disease

    Central Dopamine Neurons and Sensory Processing

    Central Catecholamine Neurons, Behavior and Neuroleptic Drugs: An Analysis to Understand the Involvement of Catecholamines in Schizophrenia

    Brain Dopamine and Behavior. A Critical Analysis of the Relationship between Dopamine Antagonism and Therapeutic Efficacy of Neuroleptic Drugs

    The Role of Adaptive Regulation in the Pathophysiology of Psychiatric Disease


    Behavioral Effects of Central Catecholamines. Concluding Remarks

    IV. Chemical Neuropathology of Schizophrenia

    Post-mortem Measurement of Enzymes in Human Brain: Evidence of a Central Noradrenergic Deficit in Schizophrenia

    Post-mortem Fluorescence Histochemistry of Monoamine Neuron Systems in the Human Brain: A New Approach in the Search for a Neuropathology of Schizophrenia

    Studies on Dopamines-Hydroxylase in Mental Disorders

    Behavioral Effects of a New Dopamine-β-Hydroxylase Inhibitor (Fusaric Acid) in Man


    Monoamine Oxidase in Schizophrenia and Other Behavioral Disorders

    Some Remarks Concerning the Possible Role of Brain Monoamines (Dopamine, Noradrenaline, Serotonin) in Mental Disorders

    Analysis of Glutamate Decarboxylase in Post-mortem Brain Tissue in Huntington's Chorea

    A New Hypothesis on the Origin of Schizophrenia

    N5.1-Methylenetetrahydrofolate Reductase Deficiency and Schizophrenia: A Working Hypothesis


    Problems of Interpretation in the Chemical Pathology of Schizophrenia

    V. Recent Advances in Historical Technology

    Introduction: Quantitative Histochemistry

    Recent Developments in Monoamine Histochemistry

    Dopamine Histofluorescence in Post-mortem Specimens of Human and Rat Striatum

    Localization of the Noradrenergic Nervous System in Human Brain

    Enzymatic-Isotopic Micromethods for the Measurement of Biogenic Amines in Brain Tissue and Body Fluids

    Genetic Control of Biogenic Amines and the Possibilities Offered by New Microanalytical Techniques for the Investigation of Human Cerebrospinal Fluid

    Multiple Detection: A New Tool for Neurochemistry and Biological Psychiatry


    VI. Enzymology and Regulation of Catecholamine Enzymes


    Immunological Localization of Dopamine-Beta-Hydroxylase on the Chromaffin Granule Membrane

    Brief Communication:

    The Subunit Structure and Carbohydrate Content of Bovine Adrenal Dopamine-β-Hydroxylase


    Introductory Remarks on Monoamine Oxidase

    On the Physico-Chemical Characterization of Monoamine Oxidase (MAO) as a Basis for the Study of its Role in Physiological and Pathological Processes


    Regulation of Catecholamine-Synthesizing Enzymes

    The Regulation of the Noradrenergic Neuron

    Genetic Differences in Mechanisms Involving Neuroregulators

    Brief Communication:

    Possible Role of Catecholamines (CH) in the Regulation of Adrenal Tyrosine Hydroxylase (TH)




    Subject Index

Product details

  • No. of pages: 390
  • Language: English
  • Copyright: © Pergamon 1975
  • Published: January 1, 1975
  • Imprint: Pergamon
  • eBook ISBN: 9781483159577

About the Editors

Steven W. Matthysse

Seymour S. Kety

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