Description

Through the use of extended graphical abstracts and some traditional text-only abstracts this collection provides, a record of and roadmap to, the research presented at The Tenth International Catecholamine Symposium (XICS) held in September of 2012. Organized around ten general themes, each is introduced by a short overview identifying interesting research programs, results and potential areas of growth. The collection is a roadmap to key research and future opportunities for new catecholamine research programs and will be of interest to neuroscientists and clinical neurologists interested in understanding the current and future state of catecholamine research.

Key Features

  • Details the leading research efforts and focus on catecholamines
  • Provides a guide to the diverse catecholamine research efforts across key themes including, Synthesis and Storage, Release and Re-uptake, Metabolism, Catecholamine Receptors and Catecholaminergic Signaling
  • Includes impact on clinical neurology, drug abuse and addiction and issues in psychiatry and psychology

Table of Contents

Preface

Theme A: Catecholamine Biosynthesis and Storage

Theme A Catecholamine Biosynthesis and Storage

Genetic Manipulation of Catecholamine Signaling in the Mouse

AADC Deficiency: Occurring in Humans; Modeled in Rodents; Treated in Patients

Tyrosine Hydrolylase and Dopamine Beta-Hydroxylase: Role of Common Genetic Variation in Adrenergic Responses to Stress and in Hypertension

Pharmacokinetic and Pharmacodynamic Properties of Etamicastat, a New DBH Inhibitor: Comparison to Nepicastat

Estradiol-Mediated Regulation of Gene Expression of Catecholamine Biosynthetic Enzymes: The Role of Membrane-Initiated Signaling with Erα

Structural Basis for Regulation of Tyrosine Hydroxlyase by the Catecholamines

Unique Regulation of TH Gene Expression in Midbrain Dopamine Neurons

Intracellular Stability of Tyrosine Hydroxylase: Phosphorylation and Proteasomal Digestion of the Enzyme

The Peripheral Interaction of Tyrosine Hydroxylase and 14-3-3γ with Negatively Charged Phospholipidic Membranes

References

Dynamic Regulation of Tyrosine Hydroxylase Gene Expression by Key Fate-Determining Transcription Factors during Dopaminergic Neuronal Development in Vivo and in Vitro

Analysis of Tyrosine Hydroxylase Isoforms and Phosphorylation in Parkinson’s Disease

Non-dopaminergic Neurons Partly Expressing Dopaminergic Phenotype: Functional Significance and Regulation

Developing Brain as an Endocrine Organ: Catecholamines Secretion and Endocrine Action

Brainstem DOPAergic System

Imaging Norepinephrine Transporters in Humans; Translational Research with PET

Imaging the Vesicular Monoamine Transporter (VMAT2) in Neurodegenerative Diseases

GTP Cyclohydrolase Regulation: Implications for Brain Development and Function

Neonatal Diagnosis of Menkes Disease by a Pattern of Plasma Catechols

Catecholamine Metab

Details

No. of pages:
328
Language:
English
Copyright:
© 2013
Published:
Imprint:
Academic Press
eBook ISBN:
9780128000731
Print ISBN:
9780128000441

About the editor

Lee Eiden

Affiliations and Expertise

Laboratory of Cellular and Molecular Regulation, National Institutes of Health, MD, USA

Reviews

"The symposium is documented by abstracts…of 206 of the papers delivered…They cover catecholamine biosynthesis and storage, catecholamine release and re-uptake, metabolism, catecholamine receptors and catecholaminergic signaling, neurology, psychiatry and psychology, drug abuse and addiction, catecholamines in the periphery…" --ProtoView.com, April 2014