Cartilage V1 - 1st Edition - ISBN: 9780123195012, 9780323139588

Cartilage V1

1st Edition

Structure, Function, and Biochemistry

Authors: Brian K. Hall
eBook ISBN: 9780323139588
Imprint: Academic Press
Published Date: 28th April 1983
Page Count: 400
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Cartilage, Volume 1: Structure, Function, and Biochemistry provides an in-depth treatment of cartilage structure, function, and biochemistry. Topics range from vertebrate and invertebrate cartilages to chondroblasts and chondrocytes, along with the use of transmission electron microscopy and scanning electron microscopy to examine cartilage. The collagens and cell kinetics of cartilage are also discussed.

Comprised of 12 chapters, this volume begins with an overview of the diversity of cartilage in vertebrates and invertebrates in terms of structure, function, and evolution. The principal common attributes of vertebrate cartilages as well as those specific parameters that usefully serve to distinguish between cartilaginous tissues at several phylogenetic levels are discussed. Function and level of function are considered, along with their correlations with the structural attributes of a specific cartilage. Subsequent chapters explore the chondroblasts and chondrocytes of cartilage, particularly how they arise and how they are maintained; the ultrastructure of cartilage; the biochemistry of cartilaginous extracellular matrices; and the kinetic and metabolic properties of cartilage cells. The final chapter analyzes the mechanisms of calcification of cartilage.

This book will be of interest to biologists and biochemists.

Table of Contents



Contents of Other Volumes

1. Vertebrate Cartilages

1. Introduction

II. Definitions and Classification

III. General Texts

IV. Antiquity of Cartilage and Bone

V. Modulation Hypothesis

VI. Principal Trends of Cartilage Evolution

VII. Epiphyses

VIII. Secondary Cartilage


2. Invertebrate Cartilages

I. Introduction and Historical Review

II. Occurrence of Cartilage in Invertebrates: Morphologic and Microscopic Observations

III. Chemistry of Invertebrate Cartilage

IV. The Plant-Like Features of Some Cartilage Tissues


3. The Chondroblast and the Chondrocyte

I. Introduction

II. The Chondrocytic Phenotype

III. Acquisition of the Chondrocytic Phenotype

IV. Precartilaginous Mesenchymal Cells

V. Regulation of Cartilage Differentiation

VI. Maintenance of the Chondrocyte Phenotype


4. Transmission Electron Microscopy of Cartilage

I. Introduction

II. Cartilage Matrix

III. Cells in Cartilage


5. Scanning Electron Microscopy of Cartilage

I. Introduction

II. Examination of Cartilage in the SEM: Previous Studies and Techniques

III. Present Study


6. Cell Kinetics of Cartilage

I. Introduction

II. Basic Concepts

III. Cell Kinetics and Overall Bone Growth

IV. The Problems and Precision of Cell Kinetics

V. Techniques in Cell Kinetics

VI. Application of Cell Kinetics

VII. Computer Modeling

VIII. Cell Kinetics and Theories of Growth Control

IX. Conclusions


7. Collagens of Cartilage

I. Introduction

II. Collagens in Different Types of Cartilage

III. Chemistry of Cartilage Collagens

IV. Biosynthesis of Cartilage Collagen

V. Synthesis of Cartilage Collagen in Vitro

VI. Immunohistochemical Localization of Type II Collagen in Tissues and Cell Cultures

VII. Degradation, Regeneration, and Autoimmunity of Collagen in Cartilage Diseases


8. Glycosaminoglycans of Cartilage

I. Introduction and Terminology

II. Biosynthesis and Regulation of Synthesis

III. Deposition and Degradation

IV. In Vitro Versus in Vivo Studies

V. Interactions with Other Molecules

VI. Abnormalities of Glycosaminoglycans and Proteoglycans

VII. Tissue-Specific Proteoglycans

VIII. Role of Proteoglycans in Development and Differentiation


9. Metabolism of Cartilage

I. Introduction

II. Respiration and Glycolysis

III. Biosynthesis of Macromolecules

IV. Degradation of Macromolecules

V. Turnover of Macromolecules

VI. Regulation of Cartilage Metabolism


10. Vascularity of Cartilage

I. Introduction

II. The Anatomy of the Cartilage Blood Supply

III. Mechanisms of the Resistance of Cartilage Matrices to Vascular Invasion

IV. The Resistance of Cartilage to Tumor Cell Invasion

V. Conclusions


11. Biomechanics of Cartilage and its Response to Biomechanical Stimuli

I. Introduction

II. Mechanical Behavior of Materials

III. Cartilage Composition and Structure in Relation to Mechanical Properties

IV. Cartilage Mechanical Properties

V. Effects of Degeneration on Cartilage Mechanical Properties

VI. Concluding Remarks


12. Calcification of Cartilage

I. Introduction

II. Process of Calcification

III. Factors Involved in Initiating Calcification

IV. Epiphyseal Cartilage Calcification

V. Discovery and Role of Matrix Vesicles

VI. Pathological Calcification of Cartilage




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© Academic Press 1983
Academic Press
eBook ISBN:

About the Author

Brian K. Hall

Brian K. Hall

I have been interested in and studying skeletal tissues since my undergraduate days in Australia in the 1960s. Those early studies on the development of secondary cartilage in embryonic birds, first published in 1967, have come full circle with the discovery of secondary cartilage in dinosaurs12. Bird watching really is flying reptile watching. Skeletal tissue development and evolution, the embryonic origins of skeletal tissues (especially those that arise from neural crest cells), and integrating development and evolution in what is now known as evo-devo have been my primary preoccupations over the past 50+ years.

Affiliations and Expertise

Department of Biology, Dalhousie University, Halifax NS Canada

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