Cardiovascular Thrombus - 1st Edition - ISBN: 9780128126158

Cardiovascular Thrombus

1st Edition

From Pathology and Clinical Presentations to Imaging, Pharmacotherapy and Interventions

Authors: On Topaz
Hardcover ISBN: 9780128126158
Imprint: Academic Press
Published Date: 1st June 2018
Page Count: 608
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Cardiovascular Thrombus: From Pathology and Clinical Presentations to Imaging, Pharmacotherapy and Interventions provides a comprehensive, up-to-date presentation of the research and clinical practice related to the contemporary aspects of the diagnosis and management of cardiovascular thrombosis. Cardiovascular thrombus is of paramount importance for researchers and practicing physicians, yet it remains one of the most challenging diagnostic and clinical scenarios. This important reference bridges the gap between research, up-to-date clinical information, and the technological facets of thrombus formation, diagnosis and management in cardiovascular medicine. The book includes a comprehensive pathology, clinical presentations, diagnosis, pharmacotherapy, interventions and future trends.

It is the perfect reference for basic science researchers and researchers of cardiology, interventional and general cardiologists, interventional and general radiologists, vascular medicine specialists, and vascular and general surgeons.

Key Features

  • Provides a comprehensive understanding of the pathophysiology, clinical presentations and diagnosis of cardiovascular thrombosis
  • Includes the most up-to-date information on the practical management of patients with thrombus related conditions
  • Written by the leading experts in the field
  • Delivers an explanation of the current and upcoming pharmacotherapy and technology available for thrombus research and treatment


Basic science researchers and researchers of cardiology, interventional and general cardiologists, interventional and general radiologists, vascular medicine specialists, vascular and general surgeons. Residents and fellows-in–training in cardiology and surgery

Table of Contents

Section 1. Pathology
1. Hemostasis and thrombosis
2. Vascular wall pathology- effect on thrombosis
3. Mechanisms of thrombosis and their relationship to atherosclerosis: Endothelial cell function and injury [trauma, infection]
4. Platelet aggregation in the pathogenesis of vascular ischemia conditions
5. Physical properties and morphologic features of thrombus
6. Pathology of arterial thrombosis
7. Thrombus types
8. The calcified thrombus: histopathology
9. Pathology of venous thrombosis
10. Hypercoagulopathy: acquired syndromes and thrombosis
11. Hypercoagulopathy: hereditary syndromes and thrombosis
12. Intra cardiac thrombosis: ventricles, atria, appendage and valves
13. Prosthetic surgical valves and TAVR thrombosis
14. Closure devices and thrombosis

Section 2. Clinical presentations
15. Thrombotic ischemic syndromes of the coronary circulation
16. Thrombotic ischemic syndromes of the brain
17. Thrombotic syndromes of the peripheral arterial circulation
18. Thrombosis of the splanchnic and mesenteric
19. Unique thrombus-containing lesions
20. Thrombosis of the venous system: DVT; portal vein; renal vein; Superior vena cava; Jugular; Budd-Chiari; cavernous sinus; cerebral
21. The angry thrombus phenomenon and the simultaneous thrombus in different vascular beds
22. Pulmonary embolism-acute
23. Pulmonary embolism: chronic
24. Platelets, thrombus and thrombosis in pregnancy
25. Atrial fibrillation and thromboembolism

Section 3. Diagnosis
26. Cardiovascular Thrombus classifications
27. Laboratory studies of thrombus and thrombosis
28. Imaging modalities

Section 4. Treatment Guidelines
29. The role of treatment guidelines-comparing the US and European approach to cardiovascular thrombus

Section 5. Pharmacotherapy
30. From Coumadin to the new anticoagulation agents
31. Antiplatelet agents: asa; heparins; LMH
32. Direct thrombin inhibitors
33. The 2b/3a receptor antagonists
34. Thienopyridines
35. Thrombolytic agents

Section 6. Interventions
36. Percutaneous approach:
37. Protection filters
38. Mechanical thrombectomy: Angiojet and X-Sizer
39. Stents: dedicated thrombus containing stent platforms
40. Extraction and vaporization devices: thrombocat and laser
41. LAA closure
42. Surgical approach

Section 6. Future trends
43. Pharmacotherapy and technology


No. of pages:
© Academic Press 2018
Academic Press
Hardcover ISBN:

About the Author

On Topaz

On Topaz is a Professor of Medicine, Cardiology and Pathology at the School of Medicine of the Medical College of Virginia/Virginia Commonwealth University and the Director of Interventional Cardiology at the McGuire Veterans Affairs in Richmond, Virginia. He is a fellow of numerous colleges and societies including the American College of Cardiology (ACC) and the American Society for Laser Medicine and Surgery. He is also a member of the American Heart Association (AHA), and the Society for Cardiac Angiography and Interventions, among others.

Professor Topaz pioneered the application of lasers for debulking of complex lesions in ischemic thrombotic coronary syndromes, especially for treatment of acute myocardial infarction, for revascularization of old bypass vein grafts, and for management of ischemic depressed left ventricular ejection fraction. He developed safe and effective lasering techniques that are utilized in coronary laser procedures around the world. Professor Topaz has authored 100 manuscripts in peer-reviewed journals, 44 abstracts and 10 book chapters, and serves as the North American Editor-in-Chief of Lasers in Medical Science. He is also on the editorial board of nine peer-reviewed cardiology journals.

Affiliations and Expertise

Professor of Medicine Cardiology and Pathology, School of Medicine, Medical College of Virginia/Virginia Commonwealth University; Director of Interventional Cardiology, McGuire Veterans Affairs; Consulting Professor in the Department of Medicine, Duke University

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