Cardiovascular Thrombus - 1st Edition - ISBN: 9780128126158, 9780128126165

Cardiovascular Thrombus

1st Edition

From Pathology and Clinical Presentations to Imaging, Pharmacotherapy and Interventions

Editors: On Topaz
eBook ISBN: 9780128126165
Hardcover ISBN: 9780128126158
Imprint: Academic Press
Published Date: 25th August 2018
Page Count: 670
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Cardiovascular Thrombus: From Pathology and Clinical Presentations to Imaging, Pharmacotherapy and Interventions provides a comprehensive, up-to-date presentation of the research and clinical practices as related to the contemporary aspects of the diagnosis and management of cardiovascular thrombosis. The formation, identification and management of cardiovascular thrombus is of paramount importance for researchers and practicing physicians, yet it remains one of the most challenging diagnostic and clinical scenarios. This important reference connects between research, up-to-date clinical knowledge, and the technological tools  available for diagnosis and management of thrombus in cardiovascular medicine. The book includes comprehensive descriptions and review of pathology, clinical presentations, diagnosis, pharmacotherapy, interventions and future trends.
It is the perfect reference for basic science students and researchers in general and interventional cardiology, general and  interventional radiology, vascular medicine specialists, and vascular, general and cardiac surgeons.

Key Features

  • Provides comprehensive presentation of the pathophysiology, clinical presentations and diagnosis of cardiovascular thrombosis
  • Includes the most up-to-date information on the practical management of patients with thrombus related conditions
  • Written by the leading experts in the field
  • Describes the current and upcoming pharmacotherapy and technology available for thrombus research and treatment


Basic science researchers, and clinicians in cardiology, radiology, hematology, interventional and vascular medicine specialists, vascular and cardiac surgeons as well as residents and fellows-in–training in medicine, radiology, hematology, cardiology and surgery.

Table of Contents

  On Topaz
  Igor Palacios
1. Histopathology of cardiovascular thrombus
  Hiroyuki Jinnouchi and Renu Virmani
2. Pathology of Arterial Thrombosis: Characteristics and Thrombus Types
  George S. Abela
3. Fibrin clot structure and function: a novel risk factor for arterial and venous thrombosis and thromboembolism
  Robert Ariens and Stephen R. Baker
4. The role of platelets in the pathophysiology of atherosclerosis and its complications
  Albert Ferro, Kerry Layne and Gabriella Passacquale
5. Mathematical models of thrombus formation and fibrinolysis
  Karin Leiderman, Brittany Bannish, Michael A. Kelley and Ada Palmisano
6. Animal models of thrombosis
  Gemma Vilahur
7. Imaging Modalities for Detection and Treatment of Cardiovascular Thrombus
  Claudia A. Martinez, Rodrigo Mendirichaga and Joel Fishman
8. Utilization of MRI/MRA for cardiac thrombus
  Rhoda Brosnan
9. Acute Myocardial Infarction: STEMI and NSTEMI
  Peter O’Kane and Kalpa De Silva
10. Acute Coronary Syndrome: thrombotic lesions in patients with unstable angina
  Ion S. Jovin, Gabriele Cioni and Nayef A. Abouzaki
11. Practical perspectives on the guidelines for management of coronary thrombus
  Elliott Smith
12. Thrombus classifications – critical tool for diagnostic and interventional cardiovascular procedures
  On Topaz
13. Impact of thrombus burden on myocardial damage in the setting of primary PCI
  Massimo Napodano and Antonio Landi
14. The impact of thrombus as a cause and as a result of complicated PCI
  Emmanouil S. Brilakis
15. Stent Thrombosis: Early, Late and Very Late
  Thomas E. Watts III, Massoud Leesar and Arka Chatterjee
  Dean Kereiakes
17. Aspiration catheters & Protection filters
  Anthony A. Bavry and Dhruv Mahtta
18. Power sourced mechanical thrombectomy in the management of thrombus-containing atherosclerotic lesions
  On Topaz
19. Dedicated thrombus-containing stent platforms
  Ran Kornowski
20. Dissolution of thrombus with ultrasound: a journey through physics, basic research and clinical utilization
  Uri Rosenschein
21. The role and impact of thrombus in formation and revascularization of chronic total occlusions
  On Topaz
22. Interventions in a spectrum of thrombotic lesions: real life experience in the cardiac catheterization suites of a large size tertiary care center
  P.P.T. de Jaegere
23. Atrial fibrillation : Prevalence, types, and clinical implications
  Gregory K. Jones
24. Acute and chronic pulmonary embolism: perspectives on diagnosis and management
  Mordechai Reuven Kramer and Avraham Unterman
25. Surgical management of cardiovascular thrombotic conditions
  Tomas A. Salerno
26. The spectrum of clinical presentations and management options for the treatment of degenerative atherothrombotic disease of saphenous vein grafts
  Haim Danenberg
27. Prosthetic Heart Valve Thrombosis
  Felipe Albuquerque, Eduardo De Marchena and Giselle Baquero
  Ali N. Azadani and Danny Dvir
29. Ventricular Assist Device Thrombosis: Past, Present and Future
  Neil Pendril Lewis
30. Vascular Closure Devices and Thrombosis
  Brian Clapp and Matthew James Ryan
31. Management strategies for thrombosis of major abdominal aortic branches: the superior mesenteric and  renal arteries
  Mohammed Aladdin
32. Thrombotic lesions in the lower extremity peripheral arteries:  diagnosis and management
  Nicolas W. Shammas
33. Venous Thrombosis
  David Hirschl
34. Revascularization for acute ischemic stroke: contemporary perspectives on the role and yield of thrombolytic therapy and endovascular intervention
  Larry B. Goldstein
35. Treatment Options for Recurrent Thromboembolism in Patients with Cryptogenic Cerebrovascular Events: Medical Therapy versus Device closure or Surgical repair of Patent Foramen Ovale
  Andres Pineda and J. Kevin Harrison
36. Left Atrial Appendage Occluders – recent advances and unresolved issues
  Michael Glikson and Arwa Younis
37. Thrombophilia – contemporary perspectives
  Srikanth Nagalla
38. Infectious diseases and cardiovascular thrombosis
  Subhashis Mitra and Daniel Havlichek Jr.
39. Thrombosis in Pregnancy
  Michael Lishner and Ron Hoffman
40. The Role of Interventional Cardiology in the Management of Thrombotic Conditions in the Pediatric Population
  Satinder K. Sandhu
41. Kawasaki disease – the phenomenon of thrombotic coronary and vascular aneurysms in the young and adults - a Japanese perspective
  Takayuki Onishi
42. Thrombus Pharmacotherapy
  Sunil V. Rao, Holly L. Humphrey and James Anderson Smith
43. Antithrombotic Treatment in Patients Undergoing  Transcatheter Aortic Valve Replacement
  Amit Segev and Elad Asher
44. Antifibrinolytics: Pharmacologic Profile and Clinical Utilization
  Elizabeth Landrum Michalets
45. The Realm of Drugs, Biological Products, and Supplement  Induced Thrombosis and Thromboembolic Risk
  Brian Peek, Emily E. Wood and Benjamin Michalove


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About the Editor

On Topaz

Professor On Topaz received the MD degree in 1979 from the Sackler School of Medicine, Tel-Aviv University and completed residencies in Internal Medicine and Cardiology at the Beilinson and Meir hospitals, Israel. He is a graduate of 3 clinical and research US fellowships including Cardiovascular Pathology at the University of Minnesota [1983-1984], adult Cardiology at the University of Miami [1986-1989] and Interventional Cardiology at the Medical College of Virginia[1989-1990]. Following this extensive training he became an Assistant Professor at Case Western Reserve University and then at the University of Minnesota. In 1993 he joined the division of cardiology, Medical College of Virginia/Virginia Commonwealth University in Richmond, Virginia with a rank of Associate Professor serving as the director of interventional cardiology of the McGuire Veterans Affairs Medical Center . He was a member of the admissions committee of this school of medicine for 11 years . In 2001 he received the rank of Professor of Medicine and in 2002 received as well as a rank of Professor of Pathology. In 2010 he was nominated the chief of the division of Cardiology of Charles George Veterans Affairs Medical Center in Asheville, North Carolina with a rank of Professor of Medicine at the Duke University School of Medicine. Professor Topaz’s main clinical specialty is percutaneous interventions for complex lesion subsets in challenging coronary and peripheral vascular targets. He specializes in treatment of patients with critical lesions in the presence of depressed LVEF, severe left main disease, old saphenous vein grafts, chronic total occlusions, stent thrombosis and heart transplant allograft disease . He has special interest in revascularization of severe renal artery stenosis and severe subclavian artery occlusions. Professor Topaz is the inventor of several percutaneous revascularization techniques with advanced debulking technology for plaque extraction and thrombus removal. He is also a national and international proctor of FDA approved plaque debulking and thrombectomy devices such as laser and rheolytic thrombectomy. Professor Topaz’s clinical investigations and basic research focus on cardiovascular thrombus including pathology and exploration and development of dedicated revascularization strategies for management of thrombus and its constituents during various phases of coronary and peripheral ischemic syndromes . He has gained global recognition for contribution to the understanding and the treatment of thrombotic lesions in acute ischemic/ thrombotic coronary and peripheral syndromes and authored the chapter on The thrombus containing lesion for several editions of the Textbook of Interventional Cardiology ,edited by Topol and Teirstein and published by Elsevier. Professor Topaz is a world authority on cardiovascular lasers whereby he pioneered the contemporary coronary lasing techniques and introduced the utilization of laser revascularization in acute myocardial infarction. In addition, he developed laser application for treatment of congenital heart conditions such as pulmonic atresia. Professor Topaz conducts basic research on the effects of laser irradiation on cardiac and vascular bio-tissue with special focus on the interaction of laser energy with thrombus and platelets. He discovered the unique phenomena of laser- induced enhancement of thrombolytic agents activity and laser induced suppression of platelet aggregation. Clinically , he investigates the therapeutic outcomes of various cardiovascular lasers. Professor Topaz is a recognized researcher and scholar of cardiovascular pathology and vascular anatomy. In 2010 he discovered in several patients the existence of a previously unknown, peripheral artery which constitutes origin of both inferior phrenic arteries as a vascular trunk from the right renal artery. The importance of this discovery was further emphasized as this vessel supplies unique, also newly discovered trans diaphragmatic cardiac collaterals. Recently, he and colleagues introduced an important paradigm shift in the diagnosis and management of symptomatic chronic mesenteric ischemia with emphasis on the performance of endovascular interventions in the inferior mesenteric artery. Professor Topaz served on special study sections of the NIH and NSF and is a fellow of the American College of Cardiology, the American College of Physicians, the Society for Cardiac Angiography and Interventions, the American Society of Laser Medicine and Surgery, the Society of Vascular Medicine and a member of numerous cardiovascular societies and organizations. Professor Topaz is an invited faculty of leading international conferences in the field of interventional cardiology, whereby he participates as live case operator, lecturer, moderator , discussant and session chairperson . He has lectured, proctored and performed live coronary and peripheral interventions in many countries around the world. Between 1998 and 2005 he served as the North American Editor- in- Chief of the journal Laser in Medical Sciences, the clinical publication of the European Laser Association. He is the recipient of an NIH national research service award, the Winthrop interventional award and several teaching awards. In 2010 the McGuire Veterans Affairs medical center of Virginia Commonwealth University established the “On Topaz MD award”, presented annually to their best interventional cardiology fellow . To date, Professor Topaz has published 125 peer-reviewed articles; the textbook “Lasers in Cardiovascular interventions [Springer,UK,2016] ; 23 book chapters and 56 abstracts. He is a reviewer and editorial board member of 16 peer-reviewed journals and a member of medical advisory boards.

Affiliations and Expertise

Professor of Medicine, School of Medicine, Duke University, Chief, Division of Cardiology, Director ,Interventional Cardiology, Charles George Veterans Affairs Medical Center, Asheville, NC, USA

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