Cardiopulmonary Bypass

Cardiopulmonary Bypass

Advances in Extracorporeal Life Support

1st Edition - September 1, 2022

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  • Editors: Kaan Kırali, Joseph Coselli, Afksendiyos Kalangos

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Cardiopulmonary Bypass: Advancements in Extracorporeal Life Support provides comprehensive coverage on the technological developments and clinical applications of extracorporeal technologies, including the underlying basic science and the latest clinical advances in the field. Written by experts around the world, this book comprises all characteristics of cardiopulmonary bypass as well as chapters regarding equipment, physiology and pathology, pediatric aspects, and clinical applications. Important highlights include the latest updates regarding minimal invasive cardiopulmonary bypass (MICPB), extracorporeal circulatory and respiratory support (ECCRS) in cardiac and non-cardiac patients, ECMO support in COVID-19 and updated guidelines of extracorporeal technologies. This book is an invaluable resource to clinicians, researchers and medical students in the fields of cardiothoracic surgery, cardiac anesthesiology, intensive care, and perfusion technology.

Key Features

  • Offers comprehensive and cutting-edge knowledge of cardiopulmonary bypass and extracorporeal life support during surgery and non-surgical situations
  • Discusses basic science principles along with practical clinical applications
  • Authors are well-known experts in the field whose authoritative contributions are invaluable for early-career and experienced practitioners alike


Clinicians, researchers and medical students in the fields of cardiothoracic surgery, cardiac anesthesiology, intensive care, and perfusion technology. Health professionals with interest in extracorporeal circulation techniques

Table of Contents

  • Part I. Artificial Circulation and Respiration (Past-Present-Future)
    1. Introduction
    2. Development of Extracorporeal Circulation
    3. Present Guidelines for Extracorporeal Circulation
    4. Future Artificial Physiology: From Out to In
    5. Future Artificial Heart
    6. Future Artificial Lung
    7. Future Noninvasive Monitoring

    Part II. Cardiopulmonary Bypass Management
    8. Basics of Extracorporeal Circulation
    9. Pathophysiology of Cardiopulmonary Bypass
    10. Microcirculation of Cardiopulmonary Bypass
    11. Standards for Cardiopulmonary Bypass
    12. Cannulations for Cardiopulmonary Bypass
    13. Mechanical Pumps for Cardiopulmonary Bypass
    14. Oxygenators for Cardiopulmonary Bypass
    15. Monitoring During Cardiopulmonary Bypass
    16. Perioperative Transesophageal Echocardiography
    17. Anesthesia During Cardiopulmonary Bypass
    18. Myocardial Preservation During Cardiopulmonary Bypass
    19. Deep Hypothermic Circulatory Arrest During Cardiopulmonary Bypass
    20. Hemostasis During Cardiopulmonary Bypass

    Part III. Individual Cardiopulmonary Bypass
    21. Cardiopulmonary Bypass in Pregnancy
    22. Cardiopulmonary Bypass in Neonates and Infants
    23. Cardiopulmonary Bypass in Pediatrics
    24. Cardiopulmonary Bypass in Thoracic Aortic Surgery
    25. Cardiopulmonary Bypass in Lung Surgery

    Part IV. Special Situations for Perfusion
    26. Perfusion Ethics, Accreditation and Education
    27. Perfusion Training
    28. Perfusion Management
    29. Perfusion Accidents Management
    30. 3D Printing for Perfusion
    31. Perfusion for HIPEC

    Part V. Miniaturizing Cardiopulmonary Bypass
    32. Miniaturizing Cardiopulmonary Bypass (MICPB)
    33. MICPB in Cardiac Surgery
    34. MICPB in Heart Valve Surgery
    35. MICPB in Robotic Cardiac Surgery
    36. MICPB in Pediatrics

    Part VI. Organ Injury and Protection during Cardiopulmonary Bypass
    37. Metabolic Aspects in Cardiopulmonary Bypass
    38. Inflammatory Injury in Cardiopulmonary Bypass
    39. Inflammatory Protection and Immune Support
    40. Lung Injury in Cardiopulmonary Bypass
    41. Pulmonary Protection and Respiratory Support
    42. Brain Injury in Cardiopulmonary Bypass
    43. Cerebral Protection and Neurologic Support
    44. Kidney Injury in Cardiopulmonary Bypass
    45. Renal Protection and Nephritic Support
    46. Liver Injury and Protection in Cardiopulmonary Bypass
    47. Vessels Injury and Protection in Cardiopulmonary Bypass
    48. Infection and Protection in Cardiopulmonary Bypass

    Part VII. ECMO Management
    49. Extracorporeal Membrane Oxygenation (ECMO)
    50. Cardiac Protection and Management during ECMO
    51. Pulmonary Protection and Management during ECMO
    52. Hemorrhagic Protection and Management during ECMO
    53. Cerebral Protection and Management during ECMO
    54. Renal Protection and Management during ECMO
    55. Vascular Protection and Management during ECMO
    56. Infectious Protection and Management during ECMO
    57. Inflammatory Protection and Management during ECMO

    Part VIII. Special Situations for ECMO
    58. Ethics and Quality Assurance for ECMO
    59. Education and Training for ECMO
    60. Weaning Strategies and Awake ECMO
    61. Transportation on ECMO

    Part IX. ECMO Support in Non-Cardiac Etiology
    62. Noncardiac Application of Miniaturized ECMO
    63. ECMO in Neonates and Infants
    64. ECMO in Lung Surgery
    65. ECMO in Intracranial Surgery
    66. ECMO in Controlled Reperfusion of Whole Body (CARL)
    67. ECMO in Accidental Hypothermia
    68. ECMO in Poisoning
    69. ECMO in Trauma
    70. ECMO in COVID-ARDS
    71. ECO in Pandemics

    Part X. ECMO Support in Non-Surgical Cardiac Etiology
    72. ECMO for Challenging Percutaneous Intervention
    73. ECMO for End-stage Heart Failure
    74. ECMO for Cardiogenic Shock
    75. ECMO for Cardiopulmonary Arrest (E-CPR)

    Part XI. ECMO Support in Surgical Cardiac Etiology
    76. ECMO for Postcardiotomy Syndrome in Adults
    77. ECMO for Postcardiotomy Syndrome in Pediatrics
    78. ECMO for Right Ventricular Failure post-LVAD
    79. ECMO for Thoracic Transplantation

    Part XII. Non-ECMO Artificial Life Support
    80. Non-ECMO Artificial Circulatory Support Devices
    81. Non-ECMO Artificial Respiratory Support Devices
    82. Non-ECMO Artificial Circulatory Support for Postcardiotomy Syndrome
    83. Non-ECMO Artificial Circulatory Support for Percutaneous Interventions
    84. Non-ECMO Artificial Life Support for Thoracic Transplantation

Product details

  • No. of pages: 950
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: September 1, 2022
  • Imprint: Academic Press

About the Editors

Kaan Kırali

After finishing the Medicine Faculty of Istanbul University in 1990, Prof Kırali fulfilled MD, MSc medical mandatory service duty and began his residency training in Koşuyolu Heart and Research Hospital in 1992. Following 5 years of assistant education, he was in England and the USA for education and training in 1998. He performed his work mostly in the field of videoscopic and minimally invasive cardiac surgery, and he became a consultant cardiovascular surgeon in 1998, Assistance Professor in 1999, Associate Professor in 2002, and chief in 2005 at the same hospital. Over the last 20 years, he has focused his scientific interests on topics related to cardiovascular repairs requiring special experience. With his expertise in coronary artery surgery, minimal invasive cardiac surgery, valve repair, and aortic root surgery, he has established new methods for awake coronary bypass revascularization, new surgical approach for AVR during first and re-operations, aortic valve sparing procedure, and radiofrequency ablation. He is the pioneer of awake complete CABG with BIMA and has also developed a new aortotomy incision technique for all kinds of aortic valvular or subvalvular interventions during first and re-operations, which simplifies the procedure with/without aortic valve insertion. He has experience on cardiac failure during ECMO and developed a specific design for recovery. He has been the director of transplantation department since 2015.

Affiliations and Expertise

Professor, Koşuyolu High Specialization Education and Research Hospital, Turkey

Joseph Coselli

Prof Coselli MD, FACS specializes in the clinical evaluation and surgical treatment of diseases of the aorta, including the aortic valve and root, ascending aorta, aortic arch, descending thoracic aorta, and thoracoabdominal aorta. He is an innovator and a leader in thoracic aortic surgery, as well as emergent repair performed in patients with conditions such as acute aortic dissection or aortic rupture. He has investigated methods to reduce postoperative mortality, paralysis, and stroke; his success in improving the process of aortic repair has resulted in better patient outcomes than those achieved in previous eras. Additionally, he has utilized endovascular technology to repair aortic aneurysms by using thoracic stent-grafts. Prof Coselli has also performed over 700 Transcatheter Aortic Valve Replacement (TAVR) procedures which provide a minimally invasive technique. Prof Coselli continuously seeks out new treatment paradigms and has participated in numerous investigator-initiated and industry-sponsored research projects. Additionally, he has published several key papers describing the outcomes of clinical studies designed to determine the best approaches to preventing complications during aortic repair.

Affiliations and Expertise

Professor, Baylor College of Medicine, USA

Afksendiyos Kalangos

Prof Kalangos MD, PhD is a Greek-Swiss cardiovascular surgeon and Philanthropist. He currently serves as the Chairman of the Department of Pediatric and Congenital Cardiovascular Surgery at Mitera Hospital in Athens and as a full Professor of Pediatric Cardiovascular Surgery at Koc University Hospital in Istanbul, Turkey. He is the President and founder of the Kalangos Foundation, the President and founder of the Global Forum on Humanitarian Medicine in Cardiology and Cardiac Surgery and the President and co- founder of Global Heart Network. He was the former President of the World Society of Cardiovascular and Thoracic Surgeons in 2014-2015 and is currently the treasurer of the society. He is also the inventor of the Kalangos biodegradable annuloplasty Rin. This device is being used in the repair of the mitral and tricuspid valves especially in children.

Affiliations and Expertise

Professor, Mitera Children’s Hospital, Greece

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