Description

Cardiac Regeneration and Repair, Volume One reviews the pathology of cardiac injury and the latest advances in cell therapy.

Chapters in part one explore the pathogenesis of congestive heart failure, the mechanisms responsible for adverse cardiac matrix remodeling, and potential interventions to restore ventricular function. Part two highlights new approaches to cell therapy for cardiac regeneration, and includes chapters covering alternative routes of cell delivery, monitoring cell engraftment, and the feasibility of using allogeneic stem cells to restore cardiac function. Chapters in part three move on to highlight novel stem cells for cardiac repair, including human embryonic stem cells and human pluripotent stem cells, and detail their current status and future potential for cardiac therapy. Finally, part four explores gene therapy, and includes ultrasound-targeted or direct gene delivery as well as cell-based gene therapy for cardiac regeneration.

Cardiac Regeneration and Repair, Volume One is complemented by a second volume covering biomaterials and tissue engineering. Together, the two volumes of Cardiac Regeneration and Repair provide a comprehensive resource for clinicians, scientists, or academicians fascinated with cardiac regeneration, including those interested in cell therapy, tissue engineering, or biomaterials.

Key Features

  • Explores the pathogenesis of congestive heart failure, the mechanisms responsible for adverse cardiac matrix remodeling, and potential interventions to restore ventricular function
  • Highlights new approaches to cell therapy for cardiac regeneration and includes chapters covering alternative routes of cell delivery, monitoring cell engraftment, and the feasibility of using allogeneic stem cells to restore cardiac function
  • Explores gene therapy and includes ultrasound-targeted or direct gene delivery as well as cell-based gene therapy for cardiac regeneration

Readership

Scientists and academic researchers in the areas of cardiac regeneration and repair, tissue engineering, cell therapies, and biomaterials; Cardiovascular doctors, cardiac surgeons, and cardiologists; Stem cell researchers

Table of Contents

  • Contributor contact details
  • Woodhead Publishing Series in Biomaterials
  • Foreword
  • Introduction
  • Part I: The pathogenesis of congestive heart failure
    • Chapter 1: Cardiac matrix remodeling and heart failure
      • Abstract:
      • 1.1 Introduction
      • 1.2 Cardiac matrix remodeling in the development and progression of heart failure (HF) after myocardial infarction (MI)
      • 1.3 Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in matrix and cardiac remodeling
      • 1.4 Role of inflammation in matrix and cardiac remodeling
      • 1.5 Role of monocytes and macrophages in matrix and cardiac remodeling
      • 1.6 Extracellular matrix (ECM) and collagen deposition
      • 1.7 Treatment strategies and considerations
      • 1.8 Future trends
      • 1.9 Acknowledgments
    • Chapter 2: Cardiac biomechanics and heart dysfunction
      • Abstract:
      • 2.1 Introduction
      • 2.2 Measures of cardiac biomechanics
      • 2.3 Techniques for assessing the parameters used to quantify cardiac function
      • 2.4 Passive versus active cardiac function
      • 2.5 Effects of ischemia and infarction on cardiac biomechanics
      • 2.6 Conclusion
    • Chapter 3: Modifying matrix remodeling to prevent heart failure
      • Abstract:
      • 3.1 Introduction
      • 3.2 Clinical progress and remaining issues
      • 3.3 Extracellular matrix (ECM) remodeling in the post-myocardial infarction setting
      • 3.4 Cells that modify ECM remodeling
      • 3.5 Therapeutic options
      • 3.6 Future trends
      • 3.7 Conclusion
      • 3.8 Sources of further information and advice
      • 3.9 Acknowledgements
  • Part II: Cell therapy for cardiac regeneration and repair
    • Chapter 4: Optimal cells for cardiac repair and regeneration
      • Abstract:
      • 4.1 Introduction
      • 4.2 Cell c

Details

No. of pages:
440
Language:
English
Copyright:
© 2014
Published:
Imprint:
Woodhead Publishing
Electronic ISBN:
9780857096708
Print ISBN:
9780857096586
Print ISBN:
9780081015766

About the editors

Ren-Ke Li

Ren-Ke Li, University of Toronto, Canada.

Richard D. Weisel

Richard D. Weisel, University of Toronto, Canada.

Reviews

"This book not only serves as an invaluable resource for enhancing understanding in this field, it also provides an outstanding basis for further research. Score: 88 - 3 Stars"--Doodys.com, January 16, 2015