Cardiac Electrophysiology: From Cell to Bedside

6th Edition

Authors: Douglas Zipes Jose Jalife
Hardcover ISBN: 9781455728565
eBook ISBN: 9781455770106
Imprint: Saunders
Published Date: 25th October 2013
Page Count: 1392


2014 BMA Medical Book Awards Highly Commended in Cardiology category!

Cardiac Electrophysiology: From Cell to Bedside puts the latest knowledge in this subspecialty at your fingertips, giving you a well-rounded, expert grasp of every cardiac electrophysiology issue that affects your patient management. Drs. Zipes, Jalife, and a host of other world leaders in cardiac electrophysiology use a comprehensive, multidisciplinary approach to guide you through all of the most recent cardiac drugs, techniques, and technologies.

Key Features

  • Get well-rounded, expert views of every cardiac electrophysiology issue that affects your patient management from preeminent authorities in cardiology, physiology, pharmacology, pediatrics, biophysics, pathology, cardiothoracic surgery, and biomedical engineering from around the world.
  • Visually grasp and easily absorb complex concepts through an attractive full-color design featuring color photos, tables, flow charts, ECGs, and more!

Table of Contents

Part I. Structural and Molecular Bases of Ion Channel Function

1 Voltage-Gated Sodium Channels and Electrical Excitablility of the Heart

2 Calcium Channels in the Heart

3 Voltage-Regulated Potassium Channels

4 Structural and Molecular Bases of Inward Rectifier Potassium Channel Function

5 Mammalian Calcium Pumps in Health and Disease

6 Structural and Molecular Bases of Sarcoplasmic Reticulum Ion Channel Function

7 Structural and Molecular Bases of Mitochondrial Ion Channel Function

8 Molecular Organization, Gating, and Function of Gap Junction Channels

Part II. Biophysics of Cardiac Ion Channel Function

9 Biophysics of Normal and Abnormal Cardiac Sodium Channel Function

10 Regulation of Cardiac Calcium Channels

11 KCNQ1/KCNE1 Macromolecular Signaling Complex: Channel Microdomains and Human Disease

12 Structural Determinants and biophysical properties of hERG channel gating

13 Molecular regulation of cardiac inward rectifier potassium channels by pharmacologic agents

14 Cardiac Stretch-Activated Channels and Mechano-Electric Coupling

15 Biophysical Properties of Gap Junctions

16 Excitation-Contraction Coupling

Part III. Intermolecular Interactions and Cardiomyocyte Electrical Function

17 Ion Channel Trafficking in the Heart

18 Macromolecular Complexes and Regulation of the Sodium Channel Nav1.5

19 Calmodulin and CaMKII as Ca2+ switches for cardiac ion channels

20 Macromolecular Complexes and Cardiac Potassium Channels

21 Reciprocity of Cardiac Sodium and Potassium channels in the control of Excitability and Arrhythmias

22 The Intercalated Disc: A Molecular Network that Integrates Electrical Coupling, Intercellular Adhesion, and Cell Excitability

23 Scaffolding Proteins and Ion Channel Diseases

24 Epigenetics


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About the Author

Douglas Zipes

Affiliations and Expertise

Distinguished Professor, Emeritus Professor of Medicine, Pharmacology, and Toxicology, Emeritus Director, Division of Cardiology and the Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, IN; Editor-in-Chief, HeartRhythm, Editor-in-Chief, PracticeUpdate/Cardiology

Jose Jalife

Affiliations and Expertise

Cyrus and Jane Farrehi Professor of Cardiovascular Research,Professor of Internal Medicine, Professor of Molecular and Integrative Physiology, University of Michigan Medical School; Co-Director, University of Michigan Center for Arrhythmia Research, Ann Arbor, Michigan