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Carcinogen-Driven Mouse Models of Oncogenesis - 1st Edition - ISBN: 9780128225349

Carcinogen-Driven Mouse Models of Oncogenesis, Volume 163

1st Edition

Serial Volume Editors: Lorenzo Galluzzi Aitziber Buque
Hardcover ISBN: 9780128225349
Imprint: Academic Press
Published Date: 1st April 2021
Page Count: 362
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Table of Contents

1. Preface - Chemical carcinogenesis in mice as a model of human cancer: Pros and cons
Lorenzo Galluzzi
2. MPA/DMBA-driven mammary carcinomas
Aitziber Buqué Martinez
3. Dimethylbenz(a)anthracene-Induced Mammary Tumorigenesis in mice
Isabelle Plante
4. Urethane-induced lung carcinogenesis
Silvano Sozzani
5. Methylcholanthrene-induced fibrosarcomas
Awen Gallimore
6. BBN-driven bladder carcinomas
Janos Terzic
7. Oral squamous cell carcinomas driven by 4NQO
Nancy J. Philp
8. Analysing skin tumor development in mice by the DMBA/TPA model
Cord Brakebusch
9. DSS/AOM-driven colorectal carcinomas
David C. Montrose
10. Diethylnitrosamine-induced liver tumorigenesis in mice
Peter Hasselblatt
11. Two-stage 3-methylcholanthrene and butylated hydroxytoluene-induced lung carcinogenesis in mice
Alison K. Bauer
12. Lung carcinomas induced by NNK and LPS
Peter Di
13. Pristane-induced mammary carcinomas
Bae Hoon Lee
14. The 4-NQO mouse model: an update on a well-established in vivo model of oral carcinogenesis
Pierre Saintigny


Carcinogen-driven mouse models of oncogenesis contains a series of protocols written by world-leading experts in the field. Each of these manuscripts provides a detailed methodological description to drive carcinogen-mediated oncogenesis in mice. Among the range of protocols, the following tumor types are treated: lung carcinomas, squamous cell carcinomas of the skin, mammary carcinomas, hapatocarcinomas, colitis-associated neoplasms, fibrosarcomas and oral squamous cell carcinomas.

Key Features

    • Protocols are provided by renowned experts in the field
    • Detailed description of protocols allowing appropriate reproduction of the models
    • Author notes are included in each protocol providing useful tips and troubleshooting


    Addressed to both experienced and young researchers aimed to investigate factors regulating oncogenesis in vivo


    No. of pages:
    © Academic Press 2021
    1st April 2021
    Academic Press
    Hardcover ISBN:

    Ratings and Reviews

    About the Serial Volume Editors

    Lorenzo Galluzzi

    Lorenzo Galluzzi

    Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology. Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals: OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience.

    Affiliations and Expertise

    Assistant Professor of Cell Biology in Radiation Oncology, Department of Radiation Oncology, Weill Cornell Medical College, NY, USA

    Aitziber Buque

    Aitziber Buqué (born 1980) is currently Post-Doctoral Fellow in the laboratory of Dr. Lorenzo Galluzzi with the Department of Radiation Oncology of the Weill Cornell Medical College (New York, NY, USA). Prior to joining the Galluzzi lab (2018), Aitziber Buqué was a Post-Doctoral Fellow in the Research Team “Apoptosis, Cancer and Immunity” at the Cordeliers Research Center (Paris, France; 2014-2018), under the direction of Dr. Guido Kroemer, after receiving her PhD from the University of the Basque Country (Leioa, Spain; 2013). Aitziber Buqué is interested in the molecular, cellular and immunological mechanisms whereby breast cancer evades immunosurveillance and resists to immunotherapy, and she is the author of more than 30 scientific articles in international peer-reviewed journals.

    Affiliations and Expertise

    Post-Doctoral Fellow, Department of Radiation Oncology of the Weill Cornell Medical College, New York, NY, USA