Carbonic Anhydrases provides an interdisciplinary review of the burgeoning carbonic anhydrase (CA) research area, spanning from CAs classification (biochemical and structural features) to drug design and pharmacology of CA inhibitors and activators, finally touching on the biotechnological applications of these metalloenzymes. The book adopts a clear step-by-step approach and introduction to this intricate and highly interdisciplinary field. A diverse range of chapters from international experts speak to CA classification and distribution, the mechanisms of action and drug design of inhibitors and activators, the druggability of the various isoforms in the treatment of a multitude of diseases, and threats to human health.
Carbonic Anhydrases provides biology, biochemistry, and medicinal chemistry students and researchers a thorough discussion and update on the evergreen and expanding research area of CAs.
● Offers a full overview of CAs’ biochemical and structural features, as well as drug design and pharmacology of inhibitors and activators.
● Provides a thorough update on the newly identified isoforms, modulating chemotypes, and innovative biomedical applications.
● Describes the current biotechnological applications of CAs, including processes for CO2 capture.
● Features chapter contributions from international leaders in CA biology, medicinal chemistry, and pharmacology.
Active researchers and students in biochemistry, molecular biology, pharmaceutical science, cellular biology, applied microbiology, and biotechnology; medical chemists; clinician scientists
1: Carbonic Anhydrases: An Overview
2: α-Carbonic Anhydrases
3: β-Carbonic Anhydrases
4: γ-Carbonic Anhydrases
5: δ-Carbonic Anhydrases
6: ζ-Carbonic Anhydrases
7: η and θ-Carbonic Anhydrases
8: Human Carbonic Anhydrases: Tissue Distribution, Physiological Role and Druggability.
9: Mechanisms of Action of Carbonic Anhydrase Inhibitors: Zinc Binders
10: Mechanisms of Action of Carbonic Anhydrase Inhibitors: Compounds That Anchor to The Zinc-Bound Nucleophile.
11: Mechanisms of Action of Carbonic Anhydrase Inhibitors: Compounds Occluding the Entrance of The Active Site.
12: Mechanisms of Action of Carbonic Anhydrase Inhibitors: Compounds That Bind “Out of The Binding Site” And Compounds with An Unknown Mechanism of Action
13: Carbonic Anhydrase Inhibitors as Ophthalmologic Drugs for The Treatment of Glaucoma.
14: Carbonic Anhydrase Inhibitors as Diuretics.
15: Carbonic Anhydrase Inhibitors for The Treatment of Epilepsy and Obesity.
16: Carbonic Anhydrase Inhibitors for The Treatment of Tumors: Therapeutic, Immunologic, And Diagnostic Tools Targeting Isoforms IX And XII.
17: Carbonic Anhydrase Inhibitors for The Treatment of Neuropathic Pain and Arthritis.
18: Carbonic Anhydrases from Pathogens: Bacterial Cas And Their Inhibitors as Potential Anti-Infectives.
19: Carbonic Anhydrases from Pathogens: Fungal Cas And Their Inhibitors as Potential Antifungal Agents
20: Carbonic Anhydrases from Pathogens: Protozoan Cas And Related Inhibitors as Potential Anti-Protozoal Agents.
21: Carbonic Anhydrase Activators and Their Potential in The Pharmaceutical Field.
22: Biotechnological Applications of Carbonic Anhydrases from Extremophiles.
23: CO2 Capture by Engineered Mammalian Carbonic Anhydrases.
- No. of pages:
- © Academic Press 2020
- 1st September 2019
- Academic Press
- Paperback ISBN:
Claudiu T. Supuran received his BSc in chemistry from the Polytechnic University of Bucharest, Romania (1987) and PhD in chemistry at the same university in 1991. In 1990 he became assistant and then associate professor of chemistry at the University of Bucharest. He was a visiting scholar at University of Florida, Gainesville, USA, at Grifitth University, Brisbane, Australia and visiting professor at University of La Plata, Argentina. In 1995 he moved at the University of Florence, Italy, where he is currently assistant professor of pharmaceutical chemistry. His main research interests include medicinal chemistry, design of enzyme inhibitors and activators, heterocyclic chemistry, chemistry of sulfonamides, sulfamates and sulfamides, biologically active organo-element derivatives, QSAR studies, X-ray crystallography of metallo-enzymes, metal complexes with biologically active ligands (metal-based drugs), carbonic anhydrases, cyclooxygenases, serine proteases, matrix metalloproteinases, bacterial proteases, and amino acid derivatives among others. He has published more than 700 papers in these fields.
Full Professor, Department of Neuroscience, University of Florence, Italy
Dr. Alessio Nocentini currently works at the Department of Neuroscience, University of Florence, Italy. He recently concluded his PhD thesis, which dealt with several aspects of carbonic anhydrase, spanning from drug-design, synthesis of inhibitors, and molecular modeling to biological evaluations of carbonic anhydrase modulators. He is now a post-doctoral researcher in Professor Supuran’s research team.
Post-doc Researcher, Department of Neuroscience, University of Florence, Italy