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Carbohydrates in Drug Discovery and Development: Synthesis and Application examines important developments in the synthesis, biology and biomedical applications of carbohydrates, along with the therapeutic and pharmacological aspects of carbohydrate chemistry. In addition to the advancement in construction of oligosaccharides, chemists are also making strides in the ability to assemble glycopeptides and glycoproteins. This book covers advanced aspects of carbohydrates, starting with a brief introduction, nomenclature and classification that is followed by a discussion of glyosidic bond formation methodology, recent protocols for the synthesis of O-glycosides, N-glycosides, thioglycosides and C-glycosides, Intramolecular Aglycon Delivery (IAD), carbohydrate modification, and more.
Written by a team of international experts actively working on different aspect of synthetic carbohydrate chemistry, this book is an invaluable resource for carbohydrate chemists, natural products chemists, medicinal chemists, synthetic organic chemists and biochemists working in industry and academia.
- Gives a practical, detailed overview on a wide range of carbohydrate systems relevant for drug discovery and development
- Highlights applications of functionalized carbohydrates and their use as synthons for the construction of various systems
- Covers recent developments in the synthesis of various glycohybrid molecules
Carbohydrate chemists, natural products chemists, medicinal chemists, synthetic organic chemists, biochemists
- Recent trends and challenges on carbohydrate-based molecular scaffolding: general consideration toward impact of carbohydrates in drug discovery and development
- Heparin mimetics as tools for modulation of biology and therapy
- Bioactive C-glycosides inspired from natural products toward therapeutics
- 3-Deoxy-d-manno-oct-2-ulosonic acid (Kdo) derivatives in antibacterial drug discovery
- Sialic acid-containing molecules in drug discovery and development
- Glycan microarray: Toward drug discovery and development
- Recent developments in the synthesis of biologically relevant Iinositol derivatives
- Iminosugars in medicinal chemistry
- Carbohydrate-protein interactions: Enhancing multivalency effects through statistical rebinding
- Carbo-click in drug discovery and development: Opportunity and challenges
- Glycohybrids molecule in medicinal chemistry: Present status and future prospective
- Biologically active carbohydrate-containing macrocycles
- Carbohydrate-based antibiotics: Opportunities and challenges
- Carbohydrate-based anti-bacterial and anti-cancer vaccines
- Opportunity of plant oligosaccharides and polysaccharides in drug development
- N-acetylgalactosamine (GalNAc)-conjugates: Delivering oligonucleotide drugs to the liver
- No. of pages:
- © Elsevier 2020
- 1st August 2020
- Paperback ISBN:
Vinod K. Tiwari is an Associate Professor of Organic Chemistry at Banaras Hindu University, India. Dr. Tiwari has taught almost all branches of organic chemistry for the last 16 years. His current research focuses on synthetic carbohydrate chemistry. Dr. Tiwari has supervised twelve PhD theses and his research has been documented in 140 peer-reviewed publications. Additionally, Dr. Tiwari holds several patents & has written book chapters which have received awards from various academic societies. He is a highly-travelled scientist and has delivered over 155 invited lectures in India and abroad. Currently, Dr. Tiwari holds the position of Secretary for the Association of Carbohydrate Chemist and Technologists in India.
Associate Professor, Banaras Hindu University, Varanasi, India
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