Carbohydrate Metabolism

Carbohydrate Metabolism

And Its Disorders

1st Edition - January 1, 1968

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  • Editors: F. Dickens, W. J. Whelan, P. J. Randle
  • eBook ISBN: 9781483264271

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Carbohydrate Metabolism and its Disorders focuses on the processes and methodologies involved in carbohydrate metabolism, including detection of diabetes, hypoglycemic syndromes, cardiovascular diseases, and atherosclerosis. The selection first takes a look at the detection of diabetes in man, hormonal disturbances in diabetes, and hypoglycemia. Topics include indications for testing for diabetes, reasons for early detection, testing for diabetes with tolbutamide, glucagon, corticosteroids, and hypoglycemic syndromes. The book also ponders on the physiological aspects of carbohydrate metabolism in the fetus and newborn and glycogen-storage diseases. The publication examines dietary intake of carbohydrate in relation to diabetes and atherosclerosis and glucose tolerance in ischemic cardiovascular disease. Discussions focus on epidemiological studies of diabetes and atherosclerosis, overt diabetes mellitus, and effects of selection, age, obesity, and other factors. The book also identifies disturbances of the digestion and absorption of carbohydrates; insulin antagonists and disturbances in carbohydrate metabolism; and glycosaminoglycans in joint disorders. The selection is a valuable reference for readers interested in carbohydrate metabolism.

Table of Contents

  • Contents of Volume 2

    List of Contributors to Volume 2


    Contents of Volume 1

    Chapter 1. The Detection of Diabetes in Man

    I. Introduction 1

    II. Detection before Glucose Tolerance becomes Abnormal

    III. Some Practical Definitions of Clinical Categories of Diabetes

    IV. Reasons for Early Detection

    V. Indications for Testing for Diabetes

    VI. Testing for Diabetes with the Oral Glucose Tolerance Test

    VII. Testing for Diabetes with the Intravenous Glucose Tolerance Test

    VIII. Testing for Diabetes with Tolbutamide

    IX. Testing for Latent Diabetes with a Steroid Stress

    X. Conclusions


    Chapter 2. Hormonal Disturbances in Diabetes

    I. Introduction

    II. Insulin

    III. Growth Hormone

    IV. Corticosteroids

    V. Glucagon

    VI. Summary and Conclusions


    Chapter 3. Hypoglycemia

    I. Introduction

    II. Definition of Hypoglycemia

    III. Incidence

    IV. Clinical Manifestations

    V. Pathogenesis

    VI. Hypoglycemic Syndromes

    VII. Therapy

    VEIL Conclusions


    Chapter 4. Physiological Aspects of Carbohydrate Metabolism in the Fetus and Newborn

    I. Introduction

    II. Carbohydrate Reserves

    III. Blood Glucose

    IV. Neonatal Tolerance to Oxygen Lack

    V. Conclusions


    Chapter 5. Glycogen-Storage Diseases: Types I, III , IV, V, VII and Unclassified Glycogenoses

    I. Type I Glycogen-Storage Disease

    II. Type I I I Glycogen-Storage Disease—Limit Dextrinosis

    III. Association of Glucose 6-phosphatase Deficiency with Type III Glycogen-Storage Disease

    IV. Type IV Glycogen-Storage Disease—Amylopectinosis

    V. Type V Glycogen-Storage Disease

    VI. Phosphoglucomutase Deficiency as a Possible Cause of Glycogenosis

    VII . Type VII Glycogen-Storage Disease—Phosphofructokinase Deficiency

    VIII . Distribution of Cases of Glycogen-Storage Disease


    Chapter 6. Glycogen-Storage Diseases: Type II and Type VI Glycogenosis

    Type II Glycogenosis

    I. Definition and Symptomatology

    II. The Lysosomal α-l,4-Glucosidase

    III. Type II Glycogenosis as an Inborn Lysosomal Disease

    IV. Type II Glycogenosis with Unusual Clinical or Biochemical Manifestation

    V. Comments


    Type VI Glycogenosis

    I. Definition and Symptomatology

    II. The Activity of Phosphorylase in Biopsy of Human Liver

    III. Cases with an Excess of Glycogen in the Muscle

    IV. Type VI Glycogenosis Associated with a Fanconi Syndrome

    V. Conclusion


    Chapter 8. Glucose Tolerance in Ischaemic Cardiovascular Disease

    I. Introduction

    II. Overt Diabetes Mellitus

    III. General Review

    IV. Effects of Selection, Age, Obesity, and other Factors

    V. Control Studies

    VI. Epidemiological Studies

    VII. Variation and Clinical Implication

    VIII. Relation to Serum Lipids

    IX. Further Metabolic Aspects

    X. Summary


    Chapter 9. Disturbances of the Digestion and Absorption of Carbohydrates

    I. Introduction

    II. Disturbances of Polysaccharide Digestion

    III. Disturbances of Disaccharide Digestion

    IV. Disturbances of Monosaccharide Absorption


    Chapter 10. Glycosaminoglycans in Joint Disorders

    I. Glycosaminoglycans

    II. Changes in Glycosaminoglycans in Joint Disorders


    Chapter 7. Dietary Intake of Carbohydrate in Relation to Diabetes and Atherosclerosis

    I. Introduction

    II. The Evolution of Man's Diet

    III. The Neolithic Revolution

    IV. The Industrial Revolution

    V. The Separation of Palatability and Nutrition

    VI. Epidemiological Studies of Diabetes and Atherosclerosis

    VII. Discussion


    Chapter 11. Insulin Antagonists and Disturbances in Carbohydrate Metabolism

    I. Introduction

    II. Regulation of Circulating Insulin Activity

    III. Humoral Insulin Antagonism

    IV. Conclusions


    Chapter 12. Disturbances in Carbohydrate Metabolism: Liver Disease

    I. Introduction

    II. Impairment of Glucose Metabolism

    III. Normoglycaemia and Hypoglycaemia

    IV. Disturbed Metabolism of Sugars other than Glucose


    Chapter 13. Glycosurias Other Than Diabetes Mellitus

    I. Introduction

    II. Methods

    III. Mechanism of Melituria

    IV. Clinical Conditions Associated with Melituria


    Author Index

    Subject Index

Product details

  • No. of pages: 404
  • Language: English
  • Copyright: © Academic Press 1968
  • Published: January 1, 1968
  • Imprint: Academic Press
  • eBook ISBN: 9781483264271

About the Editors

F. Dickens

W. J. Whelan

P. J. Randle

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