- Overview of Capillary Electrophoresis in Pharmaceutical Analysis
- Theoretical Consideration in Performance of Various Modes of CE
- Equipment Considerations for Capillary Electrophoresis
- Method Development for Pharmaceutical Analysis
- Role of CE in Drug Substance and Drug Product Development
- General Considerations to Improve Performance of CE Methods
- Overview of Current Regulatory Guidance
- Qualification of CE Instrumentation
- Robustness Testing of CE Methods
- Validation of Analytical Methods
- The Need for CE Methods in Pharmacopeial Monographs
- CE in Impurity Profiling of Drugs
- Ion Analysis
- Role of CE in Biopharmaceutical Development and Quality Control
- Capillary Electrophoresis and Bioanalysis
- CE as Orthogonal Technique to Chromatography
- Capillary Electrochromatography of Pharmaceuticals
- Coupling CE and Chip-based Devices and Mass Spectrometry
Capillary electrophoresis (CE) is a powerful analytical technique that is widely used in research and development and in quality control of pharmaceuticals. Many reports of highly efficient separations and methods have been published over the past 15 years. CE offers several advantages over high-pressure or high-performance liquid chromatography (HPLC). These include simplicity, rapid analysis, automation, ruggedness, different mechanisms for selectivity, and low cost. Moreover, EC requires smaller sample size and yet offers higher efficiency and thus greater resolution power over HPLC. These characteristics are very attractive in research and development, even more so in pharmaceutical quality control (QC) and stability monitoring (SM) studies. This book will provide busy pharmaceutical scientists a complete yet concise reference guide for utilizing the versatility of CE in new drug development and quality control.
- Provides current status and future developments in CE analysis of pharmaceuticals.
- Explains how to develop and validate methods.
- Includes major pharmaceutical applications including assays and impurity testing.
This book is suitable for researchers, practitioners and consultants in the field of pharmaceuticals and related industries. It is also suitable for students to learn the basic techniques, method development and applications.
- No. of pages:
- © Academic Press 2008
- 5th August 2008
- Academic Press
- eBook ISBN:
- Hardcover ISBN:
Dr. Satinder Ahuja is a leading expert on improving water quality. He earned his PhD in analytical chemistry from the University of the Sciences, Philadelphia. He worked for Novartis Corp. in various leadership positions for over 25 years while simultaneously teaching and guiding research as an adjunct professor at Pace University for over 10 years. As president of Ahuja Consulting, he advises on quality issues relating to chemicals/pharmaceuticals and water. Dr. Ahuja has published numerous papers and more than 20 books. His latest books are “Chemistry and Water: The Science Behind Sustaining the World’s Most Crucial Resource” (Elsevier, 2016), “Food, Energy, and Water: The Chemistry Connection" (Elsevier, 2015), and “Water Reclamation and Sustainability" (Elsevier, 2014). Others include “Comprehensive Water Quality and Purification" (Elsevier, 2013), "Monitoring Water Quality: Pollution Assessment, Analysis, and Remediation" (Elsevier, 2013), "Novel Solutions to Water Pollution" (ACS Symposium Volume, 2013), "Handbook of Water Purity and Quality" (Elsevier, 2009), and "Arsenic Contamination of Water: Mechanism, Analysis, and Remediation" (Wiley, 2008). A member of the executive committee of the Rivers of the World Foundation (ROW), Dr. Ahuja has organized numerous global symposia on improving water quality, including presentations for the American Chemical Society and UNESCO.
Ahuja Consulting, Calabash, NC, USA
Johnson & Johnson Pharmaceutical Research and Development, Beerse, Belgium