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Cannabis and the Developing Brain
- 1st Edition - August 18, 2022
- Editors: Miriam Melis, Olivier J Manzoni
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 3 4 9 0 - 7
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 3 6 4 1 - 3
Marijuana is the most commonly used psychotropic drug in the United States, after alcohol. With the legalization and decriminalization of cannabis, momentum continues to build an… Read more
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Request a sales quoteMarijuana is the most commonly used psychotropic drug in the United States, after alcohol. With the legalization and decriminalization of cannabis, momentum continues to build and propelled by the reduction of stigma associated to its consumption, there is growing concern regarding the long-term impact on brain function and behavior.
Cannabis and the Developing Brain
aims to provide comprehensive research on the effects of cannabis during neurodevelopment stages (i.e., perinatal and adolescent ages). This book introduces readers to vivo neural circuits, molecular and cellular mechanisms affected by cannabis exposure during three different temporal windows of brain vulnerability. Second, it offers a unique insight to shared neurobiological features of cannabinoid exposure during different developmental periods. Lastly, Cannabis and the Developing Brain determines the adverse impact of developmental cannabinoid exposure on specific cognition, emotion and behaviors.- Reviews exposure effects on different areas and circuits of the brain
- Identifies effects of exposure at prenatal, perinatal, infant, and adolescent ages
- Includes cannabis interaction with known genetic and environmental risk factors
- Contains neurodevelopment and neuropsychiatric disorders associated with cannabis exposure
- Cover
- Title page
- Table of Contents
- Copyright
- In memoriam
- Contributors
- Preface
- Chapter 1: Pre-clinical models of neurodevelopmental cannabinoid exposure
- Abstract
- Introduction
- Model considerations
- Timing of drug administration
- Route of drug administration
- Nature of drug administered
- Dose of drug administered
- Summary
- References
- Chapter 2: Epigenetic imprint: An underlying link to developmental effects of prenatal cannabis exposure
- Abstract
- Introduction
- Molecular reprogramming after prenatal cannabinoid exposure
- Prenatal cannabis exposure and epigenetic mechanisms
- Conclusion
- References
- Chapter 3: Impact of adolescent THC exposure on later adulthood: Focus on mesocorticolimbic function and behaviors
- Abstract
- Introduction
- Cannabis-based products and devices
- Cannabinoids, endocannabinoid signaling, and brain development
- Evidence from human studies
- Evidence from rodent studies
- CBD interactions with THC during adolescence
- Conclusion
- References
- Chapter 4: Endocannabinoids and sex differences in the developing social behavior network
- Abstracts
- Introduction
- The social behavior network orchestrates expression of innate social behaviors
- Sexual differentiation of the developing brain
- Endocannabinoids in developing brain
- Adolescent playfulness is a foundational behavior for adult sociality
- The extended amygdala is a key node of the social behavior network
- Endocannabinoids developmentally program playfulness
- Endocannabinoids regulate microglia phagocytic activity in the developing amygdala
- The medial preoptic area is also a key node in the social behavior network
- Conclusions and open questions
- References
- Chapter 5: Behavioral consequences of pre/peri-natal Cannabis exposure
- Abstract
- Acknowledgment
- Introduction
- Clinical studies on the behavioral consequences of maternal Cannabis exposure
- Rodent studies on the behavioral consequences of maternal cannabinoid exposure
- Future perspectives
- Conclusions
- References
- Chapter 6: Correlates and consequences of cannabinoid exposure on adolescent brain remodeling: Focus on glial cells and epigenetics
- Abstract
- Introduction
- Glial cells
- Epigenetics
- References
- Chapter 7: Effects of prenatal THC exposure on the mesolimbic dopamine system: Unveiling an endophenotype of sensory information processing deficits
- Abstract
- Introduction
- Pre-natal cannabis exposure as an environmental risk factor for neuropsychiatric disorders
- Pre-natal cannabis exposure impacts on the offspring mesolimbic dopamine system
- Sex differences in the effects of pre-natal cannabis exposure on mesolimbic dopamine system function
- Measuring vulnerability to mental illness induced by pre-natal cannabis exposure: A path toward an early clinical staging
- Concluding remarks
- References
- Chapter 8: Perinatal cannabis exposure and long-term consequences on synaptic programming
- Abstract
- Acknowledgments
- Parental germline cannabis exposure could affect progeny through transgenerational epigenetic alterations
- Cannabinoids exposure and peri-embryo implantation influences
- Perinatal cannabis exposure and long-term consequences on synaptic programming
- Conclusions
- References
- Chapter 9: Molecular and cellular principles of endocannabinoid signaling and their sensitivity to cannabis in the developing brain
- Abstract
- Introduction
- Cannabis use during pregnancy
- The endocannabinoid system
- Pre-natal endocannabinoid signaling and the adverse developmental outcomes of its disruption
- Post-natal endocannabinoid signaling and adolescent circuit disruption
- Conclusion
- References
- Chapter 10: How adolescent cannabinoid exposure sets the stage for long-term emotional and cognitive dysregulation: Impacts on molecular and neuronal risk pathways
- Abstract
- Introduction
- How cannabinoids control emotional processing: Convergent impacts on mesocorticolimbic dopamine states
- Cannabinoid transmission in pre-frontal cortex regulates emotional processing through control of sub-cortical dopamine
- Translational rodent models of adolescent cannabinoid exposure
- Effects of neurodevelopmental cannabinoid exposure on emotional processing circuits: Addiction implications
- Adolescent cannabinoid exposure alters dopaminergic, glutamatergic and GABAergic signaling and associated molecular pathways: Implication for schizophrenia vulnerability
- Effects of adolescent cannabinoid exposure on long-term mesolimbic dopamine activity states
- Effects of adolescent cannabinoid exposure on pre-frontal cortical regulation of sub-cortical dopamine activity: Impacts on molecular biomarkers for schizophrenia and other neuropsychiatric disorders
- Effects of adolescent cannabinoid exposure on pre-frontal cortical GABAergic and glutamatergic functional balance: Implications for the pathophysiology of schizophrenia
- Conclusions and future directions
- References
- Chapter 11: Molecular mechanisms underlying cannabis-induced risk of psychosis
- Abstract
- Introduction
- Schizophrenia
- Conclusions
- References
- Chapter 12: Synthetic cannabinoids: State-of-the-art with a focus on fertility and development
- Abstract
- The emergence of synthetic cannabinoids
- Chemical structure and nomenclature
- Epidemiology, patterns of use, and legal status
- Pharmacology
- Clinical aspects
- Synthetic cannabinoids and fertility
- References
- Chapter 13: Prenatal THC exposure interferes with the neurodevelopmental role of endocannabinoid signaling
- Abstract
- Introduction
- The ECB system in neurogenic niches
- Role of ECB signaling in pyramidal neuron development
- Role of the ECB system in GABAergic interneuron development
- Long-lasting consequences of prenatal THC exposure
- Contribution of prenatal ECB signaling alterations to neurodevelopmental disorders
- Prenatal cannabinoid exposure in human-based models
- Conclusions
- References
- Chapter 14: Cannabis effects on the adolescent brain
- Abstract
- Introduction
- Adolescence is a critical period of brain development
- Endogenous cannabinoid (eCB) system in the adolescent brain
- Cannabis and the adolescent brain
- Genetic vulnerability to cannabis
- Conclusion and future directions
- References
- Index
- No. of pages: 360
- Language: English
- Edition: 1
- Published: August 18, 2022
- Imprint: Academic Press
- Paperback ISBN: 9780128234907
- eBook ISBN: 9780128236413
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Miriam Melis
Miriam Melis is an Associate Professor at the University of Cagliari, Italy. She holds a PharmD (University of Palermo, 1993) as well as a PhD in Neuroscience (University of Cagliari, 2011). During her career she worked as a Research Fellow for two years at the Ernest Gallo Clinic and Research Center at UCSF and as a Visiting Scientist at Lund Universitet Wallenberg Neuroscience Center in 2011. Her research is focused on understanding neurobiological mechanisms (i.e., adaptations of both mesocorticolimbic dopamine and endocannabinoid signaling) of resilience and susceptibility to adverse neurodevelopmental outcomes leading to neuropsychiatric disorders (e.g., psychotic- spectrum, substance use disorder, antisocial behavior, anxiety, depression). She has published 46 research papers, 5 book chapters and edited two books specifically on the effects of (endo)cannabinoids in the CNS.
Affiliations and expertise
Department of Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, ItalyOM
Olivier J Manzoni
Olivier Manzoni is a Research Director at INSERM in Marseille and director of the International Associated Laboratory CannaLab (University of Indiana, Bloomington USA / Aix-Marseille University, France). His research is centered on understanding the molecular basis of synaptic plasticity in normal and pathological conditions, with a focus on the function of the endocannabinoid system and the effects of cannabis during lifetime.
Affiliations and expertise
Research Director at INSERM in Marseille, Director of the International Associated Laboratory CannaLab (University of Indiana, Bloomington USA / Aix-Marseille University), FranceRead Cannabis and the Developing Brain on ScienceDirect