1st Edition

Oxidative Stress and Dietary Antioxidants

Editors: Victor Preedy
Hardcover ISBN: 9780124052055
eBook ISBN: 9780124055247
Imprint: Academic Press
Published Date: 5th March 2014
Page Count: 308
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Cancer: Oxidative Stress and Dietary Antioxidants bridges the trans-disciplinary divide and covers in a single volume the science of oxidative stress in cancer and then the potentially therapeutic usage of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial and that oxidative stress is a single component of this.

Oncologists, cancer researchers, and nutritionists are separated by divergent skills and professional disciplines that need to be bridged in order to advance preventative as well as treatment strategies. While oncologists and cancer researchers may study the underlying pathogenesis of cancer, they are less likely to be conversant in the science of nutrition and dietetics. On the other hand, nutritionists and dietitians are less conversant with the detailed clinical background and science of oncology. This book addresses this gap and brings each of these disciplines to bear on the processes inherent in the oxidative stress of cancer.

Key Features

  • Nutritionists can apply information related to mitochondrial oxidative stress in one disease to diet-related strategies in another unrelated disease
  • Dietitians can prescribe new foods or diets containing anti-oxidants for conditions resistant to conventional pharmacological treatments
  • Dietitians, after learning about the basic biology of oxidative stress, will be able to suggest new treatments to their multidisciplinary teams
  • Nutritionists and dietitians will gain an understanding of cell signaling, and be able to suggest new preventative or therapeutic strategies with anti-oxidant rich foods


Nutritionists, dieticians, and cancer researchers

Table of Contents


List of Contributors

Section 1 Oxidative Stress and Cancer

Chapter 1. The Role of Oxidative Stress in Breast Cancer


Oxidative Stress as a Driver of Breast Cancer Development and Progression

Oxidative Stress Response and Adaptation Mechanisms in Breast Cancer

Interesting Findings, Limitations, and Future Directions

Concluding Remarks

Summary Points

Chapter 2. Oxidative Stress and Prostate Cancer


Causes of Oxidative Stress in Prostate Cancer

Role of Oxidative Stress in Pathogenesis of Prostate Cancer

Prostate Cancer Risk Factors and Their Links to Oxidative Stress


Summary Points

Chapter 3. Oxidative Stress in Lung Cancer


Lung Cancer

Etiology of Lung Cancer

Tobacco Smoking and Oxidants

Silica and Oxidants

Asbestos and Oxidants

Domestic Cooking and Oxidants

Role of Oxidants in Normal Physiology

Inflammation and Oxidative Stress

Oxidative Stress Leads to DNA Mutations and Lung Cancer

Lipid and Protein Peroxidation

Oxidant/Antioxidant Disequilibrium

Antioxidants and Lung Cancer Chemoprevention


Summary Points

Chapter 4. Oxidative Stress and Stomach Cancer


H. pylori and Oxidative Stress


Nonsteroidal Anti-Inflammatory Drugs and Aspirin

Ischemia/Reperfusion Injury

Reactive Oxygen Species

Reactive Nitrogen Species

Antioxidants and Stomach Cancer


Summary Points

Chapter 5. The Role of Oxidative Stress in Ovarian Cancer: Implications fo


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About the Editor

Victor Preedy

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC is a senior member of King's College London. He is also Director of the Genomics Centre and a member of the Faculty of Life Sciences and Medicine. Professor Preedy has longstanding academic interests in substance misuse especially in relation to health and well being. He is a member of the Editorial Board of Drug and Alcohol Dependence and a founding member of the Editorial Board of Addiction Biology. In his career Professor Preedy was Reader at the Addictive Behaviour Centre at The University of Roehampton, and also Reader at the School of Pharmacy (now part of University College London; UCL). Professor Preedy is Editor of the influential works The Handbook Of Alcohol Related Pathology, The Neuropathology of Drug Addictions and Substance Misuse and The Handbook of Cannabis and Related Pathologies (all published by Academic Press-Elsevier). Professor Preedy graduated in 1974 with an Honours Degree in Biology and Physiology with Pharmacology. He gained his University of London PhD in 1981. In 1992, he received his Membership of the Royal College of Pathologists and in 1993 he gained his second doctoral degree (DSc). Professor Preedy was elected as a Fellow of the Institute of Biology in 1995 and also as a Fellow to the Royal College of Pathologists in 2000. He was then elected as a Fellow of the Royal Society for the Promotion of Health (2004) and The Royal Institute of Public Health and Hygiene (2004). In 2009, Professor Preedy became a Fellow of the Royal Society for Public Health and in 2012 a Fellow of the Royal Society of Chemistry. To his credit, Professor Preedy has published over 600 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and numerous books and volumes.

Affiliations and Expertise

Department of Dietetics, King's College London, UK