Cancer: Oxidative Stress and Dietary Antioxidants bridges the trans-disciplinary divide and covers in a single volume the science of oxidative stress in cancer and then the potentially therapeutic usage of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial and that oxidative stress is a single component of this.

Oncologists, cancer researchers, and nutritionists are separated by divergent skills and professional disciplines that need to be bridged in order to advance preventative as well as treatment strategies. While oncologists and cancer researchers may study the underlying pathogenesis of cancer, they are less likely to be conversant in the science of nutrition and dietetics. On the other hand, nutritionists and dietitians are less conversant with the detailed clinical background and science of oncology. This book addresses this gap and brings each of these disciplines to bear on the processes inherent in the oxidative stress of cancer.

Key Features

  • Nutritionists can apply information related to mitochondrial oxidative stress in one disease to diet-related strategies in another unrelated disease
  • Dietitians can prescribe new foods or diets containing anti-oxidants for conditions resistant to conventional pharmacological treatments
  • Dietitians, after learning about the basic biology of oxidative stress, will be able to suggest new treatments to their multidisciplinary teams
  • Nutritionists and dietitians will gain an understanding of cell signaling, and be able to suggest new preventative or therapeutic strategies with anti-oxidant rich foods


Nutritionists, dieticians, and cancer researchers

Table of Contents


List of Contributors

Section 1 Oxidative Stress and Cancer

Chapter 1. The Role of Oxidative Stress in Breast Cancer


Oxidative Stress as a Driver of Breast Cancer Development and Progression

Oxidative Stress Response and Adaptation Mechanisms in Breast Cancer

Interesting Findings, Limitations, and Future Directions

Concluding Remarks

Summary Points

Chapter 2. Oxidative Stress and Prostate Cancer


Causes of Oxidative Stress in Prostate Cancer

Role of Oxidative Stress in Pathogenesis of Prostate Cancer

Prostate Cancer Risk Factors and Their Links to Oxidative Stress


Summary Points

Chapter 3. Oxidative Stress in Lung Cancer


Lung Cancer

Etiology of Lung Cancer

Tobacco Smoking and Oxidants

Silica and Oxidants

Asbestos and Oxidants

Domestic Cooking and Oxidants

Role of Oxidants in Normal Physiology

Inflammation and Oxidative Stress

Oxidative Stress Leads to DNA Mutations and Lung Cancer

Lipid and Protein Peroxidation

Oxidant/Antioxidant Disequilibrium

Antioxidants and Lung Cancer Chemoprevention


Summary Points

Chapter 4. Oxidative Stress and Stomach Cancer


H. pylori and Oxidative Stress


Nonsteroidal Anti-Inflammatory Drugs and Aspirin

Ischemia/Reperfusion Injury

Reactive Oxygen Species

Reactive Nitrogen Species

Antioxidants and Stomach Cancer


Summary Points

Chapter 5. The Role of Oxidative Stress in Ovarian Cancer: Implications fo


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© 2014
Academic Press
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