Cancer Stem Cells - 1st Edition - ISBN: 9780128038925, 9780128039342

Cancer Stem Cells

1st Edition

Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance

Editors: Huiping Liu Justin Lathia
eBook ISBN: 9780128039342
Hardcover ISBN: 9780128038925
Imprint: Academic Press
Published Date: 1st September 2016
Page Count: 542
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Description

Cancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance introduces the basic concepts and advanced understanding of cancer stem cells, covering general overviews, organ-specific identifications, and their characteristic mechanisms. The book also explores innovative therapeutic strategies in preclinical and clinical trials to target cancer stem cells, remove the roots of cancer, eliminate the seeds of metastasis, overcome the resistance of therapies, and contribute to the eradication of cancer.

The book includes contributions from leading, worldwide experts in the field, helping readers embrace new hope in their quest to eradicate cancer with emerging clinical trials on treating cancer stem cells in combination with other therapies.

Key Features

  • Provides an authoritative and complete overview of cancer stem cells
  • Includes comprehensive coverage of current therapeutic strategies targeting cancer stem cells
  • Deepens a reader’s technical expertise in cancer stem cell biology

Readership

Graduate students, postdocs, and principal investigators in both academia and industry within the fields of cancer research, pharmaceutical science, molecular biology, and genetics

Table of Contents

  • Dedication
  • List of Contributors
  • Foreword by Jane Visvader
  • Foreword by Stanton L. Gerson
  • Preface
  • Acknowledgments
  • Section 1. CSC Overview and Methodology
    • Chapter 1. Introduction: Cancer Stem Cells
      • Introduction
      • Cancer Stem Cell Origins
      • Identification of the Cancer Stem Cell Population
      • Mouse Models of Cancer Stem Cell Function
      • Strategies for Targeting Cancer Stem Cell
      • Future of Cancer Stem Cell-Directed Therapies
      • Conclusion
      • List of Acronyms and Abbreviations
    • Chapter 2. Overview: Cancer Stem Cell Self-Renewal
      • Definition of Self-renewal in Cancer Stem Cells
      • Assays to Measure Self-Renewal Potential of Cancer Stem Cells
      • Modulators of Self-Renewal in Cancer Stem Cells
      • Conclusion
      • Glossary
      • List of Acronyms and Abbreviations
    • Chapter 3. Enrichment and Interrogation of Cancer Stem Cells
      • Introduction
      • Enrichment for Cancer Stem Cells
      • Functional Analysis
      • Conclusion and Future Directions
      • List of Acronyms and Abbreviations
  • Section 2. CSCs in Representative Organ Systems
    • Chapter 4. Critical Updates to the Leukemia Stem Cell Model
      • Introduction
      • The Original Leukemia Stem Cell Model
      • With Better Flow-Sorting Protocols, Leukemia Stem Cells Are Exclusively Progenitors, Not Hematopoietic Stem Cells, by Surface Phenotype
      • Evidence for Leukemia Stem Cells and Resistance
      • Other Mechanistic Explanations for Resistance
      • Master Transcription Factor Expression in Leukemia Stem Cells and Hematopoietic Stem Cells
      • The Most Frequent Mutations in Acute Myeloid Leukemia, in NPM1 and FLT3, Are in Committed Progenitors, Not Hematopoietic Stem Cells
      • Do Founder Mutations Expand Hematopoietic Stem Cells and/or Expand Committed Progenitors?
      • The Revised Model
      • Practical, Immediate Implications of the Revised Model
      • Conclusion
      • List of Acronyms and Abbreviations
    • Chapter 5. Breast Cancer Stem Cells and the Move Toward High-Resolution Stem Cell Systems
      • Introduction
      • Origins in Development
      • The Mammary Gland as a Classic Stem Cell–Driven System
      • Identification of Breast Cancer Stem Cells
      • Caveats of the Cancer Stem Cell Assay
      • Associated Cancer Stem Cell Markers and Regulators
      • Genome Wide Molecular Profiling in Breast Cancer
      • Stem Cell Programs in Breast Cancer
      • An Inducible Stemness
      • Tumor-Associated Reprogramming
      • Tackling Heterogeneity at Single-Cell Resolution
      • Conclusion
      • List of Acronyms and Abbreviations
    • Chapter 6. Lung Cancer Stem Cells: Drivers of a Genetically and Histologically Complex Disease
      • Normal Lung Stem Cells
      • The Cancer Stem Cell Model in Lung Cancer
      • Targeting Lung Cancer Stem Cells Therapeutically
      • Glossary
      • List of Acronyms and Abbreviations
    • Chapter 7. Colorectal Cancer Stem Cells
      • Introduction
      • Molecular Mechanisms and Pathways Regulating Colorectal Cancer Stem Cells
      • Colorectal Cancer Stem Cells and Microenvironment
      • Colorectal Cancer Stem Cells and Metastases
      • Cancer Stem Cell and Chemoresistance
      • Therapeutically Targeting Colorectal Cancer Stem Cells
      • Conclusion
      • Glossary
      • List of Acronyms and Abbreviations
    • Chapter 8. Targeting Bladder Cancer Stem Cells: One Step Closer to the Clinic?
      • Introduction
      • Bladder Cancer Stem Cells
      • Bladder Cancer Stem Cell Signaling
      • Prognostic Role of Cancer Stem Cells
      • Conclusions
      • List of Acronyms and Abbreviations
    • Chapter 9. Cancer Stem Cells as New Therapeutic Targets for Ovarian Cancer
      • Introduction
      • Ovarian Cancer Biology and Pathology
      • Isolation and Characterization of Ovarian Cancer Stem Cells
      • Ovarian Cancer Stem Cells and Drug Resistance
      • Therapeutic Approaches for Eradicating Ovarian Cancer Stem Cells
      • Conclusions
      • List of Acronyms and Abbreviations
  • Section 3. CSC Features and Mechanisms
    • Chapter 10. Understanding Cancer Cells of Origin in Cutaneous Tumors
      • Introduction
      • Cancer Cells of Origin Versus Cancer Stem Cells
      • Identifying Cancer Cells of Origin
      • Stem Cell Niches of the Epidermis
      • Cancer Cells of Origin in Cutaneous Tumors
      • Melanocytic Tumor Initiation
      • Concluding Remarks and Future Directions
      • List of Acronyms and Abbreviations
    • Chapter 11. Asymmetric Division of Cancer Stem Cells
      • Introduction
      • Asymmetric Cell Division in Unicellular Organisms
      • Asymmetric Cell Division in Multicellular Organisms
      • Drosophila Melanogaster Neuroblasts—A Model System for Classic, Intrinsic Asymmetric Cell Divisions
      • Asymmetric Cell Division and Cancer
      • Concluding Remarks and Future Directions
      • List of Acronyms and Abbreviations
    • Chapter 12. Metastasis and Metastatic Cells: A Historical Perspective and Current Analysis
      • Introduction
      • The Metastatic Cascade
      • Cancer Stem Cells and Metastasis: Prostate Cancer as an Example
      • Circulating Tumor Cells and Metastasis
      • The Role of Epithelial-to-Mesenchymal Transition in Metastasis
      • Concluding Remarks
      • List of Acronyms and Abbreviations
    • Chapter 13. Cancer Stem Cells: Metastasis and Evasion From the Host Immune Responses
      • Cancer Stem Cells, Metastasis, and Host Immunity: An Overview
      • Cancer Stem Cells and Metastasis
      • The Interplay Between Immune Responses and Cancer
      • Conclusions and Future Direction
      • Glossary
      • List of Acronyms and Abbreviations
    • Chapter 14. Cancer Stem Cells and Tumor-Associated Macrophages
      • Introduction
      • The Origin of Tumor-Associated Macrophages
      • General Properties of Tumor-Associated Macrophages
      • Cancer Stem Cells and Tumor-Associated Macrophages
      • Protumor Activities of Tumor-Associated Macrophages
      • Recruitment of Tumor-Associated Macrophages by Cancer Cells
      • Education of Tumor-Associated Macrophages by Cancer Cells
      • Tumor-Associated Macrophages and Cancer Therapies
      • Concluding Remarks
      • List of Acronyms and Abbreviations
    • Chapter 15. The Mechanisms of Therapy Resistance in Cancer Stem Cells
      • Evidence of Cancer Stem Cells
      • Evidence of Therapy Resistance
      • Resistance Mechanisms and Strategies to Sensitize Cancer Stem Cells
      • Resistance and Tumor Evolution
      • Conclusion
      • List of Abbreviations
    • Chapter 16. Adipose Tissue-Derived Stem Cells in Regenerative Medicine and Impact on Cancer
      • Adult Somatic Stem Cells
      • Adipose Tissue
      • Obesity and Cancer
      • Broad Utility of Adipose Tissue-Derived Stem Cells in Regenerative Medicine
      • Conclusions and Perspectives
      • Glossary
      • List of Acronyms and Abbreviations
  • Section 4. Clinical Applications
    • Chapter 17. From Research to the Clinic: Targeting Stem Cell Pathways in Cancer
      • Introduction
      • Wnt Pathway Antagonists
      • Notch Pathway Antagonists
      • Conclusions
      • List of Abbreviations
    • Chapter 18. Targeted Therapies for Glioma Stem Cells
      • Introduction
      • Tumor Niches/Microenvironments
      • Glioma Stem Cell as a Therapeutic Target
      • Conclusion
      • List of Acronyms and Abbreviations
    • Chapter 19. Circulating Tumor Cells, Cancer Stem Cells, and Emerging Microfluidic Detection Technologies With Clinical Applications
      • Introduction
      • Clinical and Biological Significance of Circulating Tumor Cells
      • Evolution of Circulating Tumor Cell Isolation Technologies
      • Microfluidic Technologies Enabling Further Circulating Tumor Cell Characterization and Downstream Analysis
      • Summary of Circulating Tumor Cell Characterization Approaches
      • Conclusion
      • List of Acronyms and Abbreviations
  • Index

Details

No. of pages:
542
Language:
English
Copyright:
© Academic Press 2017
Published:
Imprint:
Academic Press
eBook ISBN:
9780128039342
Hardcover ISBN:
9780128038925

About the Editor

Huiping Liu

Dr. Huiping Liu is an expert in breast cancer stem cells and metastasis. She is co-director of the Cancer Stem Cell Conference in 2014 and 2016 with Justin Lathia. Dr. Liu’s research recently has been focused on thoroughly understanding the role of microRNAs in breast cancer stem cells, metastasis, and therapy resistance. The goals of the Liu laboratory are to control metastasis and eliminate the mortality associated with breast cancer and other types of cancer. She is known as an active collaborator – bridging research in basic science, engineering, and clinical medicine by engaging physicians and researchers across many institutions. Thus, she is very well known in the field and highly regarded as both a researcher and conference organizer.

Affiliations and Expertise

Assistant Professor, Department of Pathology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA

Justin Lathia

Dr. Lathia is an expert in brain tumor stem cells. He is co-director of the Cancer Stem Cell Conference in 2014 and 2016 with Huiping Liu. Dr. Lathia’s research has two main areas of focus: using in vivo imaging models to interrogate the tumor microenvironment and examining communication mechanisms used by cancer stem cells to promote their maintenance. His lab is focused on understanding cancer stem cells in real time, so they can be better eliminated by therapy and, thus, prevent tumors from forming, metastasizing, and becoming resistant to therapy.

Affiliations and Expertise

Assistant Professor, Department of Cellular and Molecular Medicine (NC10), Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA