Cancer Immunotherapy

2nd Edition

Immune Suppression and Tumor Growth

Editors: George Prendergast Elizabeth Jaffee
Hardcover ISBN: 9780123942968
eBook ISBN: 9780123946331
Imprint: Academic Press
Published Date: 29th July 2013
Page Count: 684
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There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This book highlights emerging new principles of immune suppression that drive cancer, and it offers radically new ideas about how therapy can be improved by attacking these principles. Following work that firmly establishes immune escape as an essential trait of cancer, recent studies have now defined specific mechanisms of tumor immune suppression. It also demonstrates how attacking tumors with molecular targeted therapeutics or traditional chemotherapeutic drugs can produce potent anti-tumor effects in preclinical models. This book provides basic, translational, and clinical cancer researchers with an indispensable overview of immune escape as a critical trait in cancer and how applying specific combinations of immunotherapy and chemotherapy to attack this trait may radically improve the treatment of advanced disease.

Key Features

  • Offers a synthesis of concepts that are useful to cancer immunologists and pharmacologists, who tend to work in disparate fields with little cross-communication
  • Drs. Prendergast and Jaffee are internationally recognized leaders in cancer biology and immunology who have created a unique synthesis of fundamental and applied concepts in this important new area of cancer research
  • Summarizes the latest insights into how immune escape defines an essential trait of cancer
  • Includes numerous illustrations, including how molecular-targeted therapeutic drugs or traditional chemotherapy can be combined with immunotherapy to improve anti-tumor efficacy and how reversing immune suppression by the tumor can cause tumor regression


Basic, translational, and clinical cancer researchers as well as practicing oncologists and their patients

Table of Contents

List of Contributors

Chapter 1. Introduction


I Summary

II Historical Background

III The Challenge of Cancer

IV Parts of the Book


Section 1: Principles of Basic Immunology

Chapter 2. Components of the Immune System

I Overview

II Principal Tissues and Organs

III Cells of the Immune System

IV Immune Responses

V Lymphocyte Recognition of Antigen

VI Effector Functions


Chapter 3. Adaptive Immunity: B Cells and Antibodies

I Introduction to B Cells

II B-Cell Development

III Mature B Cells

IV Antibody Function

V B Cells and Cancer

VI Conclusions


Chapter 4. Adaptive Immunity: T Cells and Cytokines

I An Overview of the Events That Initiate an Adaptive Immune Response

II T-cell Activation: A Deeper Look

III The Differentiation of Naïve T Cells into Effector T Cells

IV The Significance of Polarizing Cytokines

V CD8+ T Cells Develop into Cytotoxic Lymphocytes

VI The Activities of Effector and Memory T Cells in Tissues

VII Two Major Types of Memory T Cells Remain after Antigen is Cleared

VIII The Challenges Faced by the Adaptive Immune System When Responding to Tumors

Further Reading

Chapter 5. Dendritic Cells: Antigen Processing and Presentation

I Dendritic Cells: Introduction

II Antigen Processing and Presentation



V Alternate Pathways of Antigen Presentation

VI Dendritic Cell Subsets and Specialized Functions

VII Human DC Subsets

VIII Conclusions


Chapter 6. Mucosal Immunity

I Overview

II Mucosal Surfaces are the Major Portals of Entry for Antigen

III Epithelial Barrier

IV Inductive and Effector S


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© Academic Press 2013
Academic Press
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About the Editor

George Prendergast

Affiliations and Expertise

Lankenau Institute for Medical Research, Wynnewood, PA, U.S.A.

Elizabeth Jaffee

Affiliations and Expertise

Department of Oncology, SKCCC, Johns Hopkins University, Baltimore, MD, U.S.A.


" indispensable overview of immune escape as a critical trait in cancer and how applying specific combinations of immunotherapy and chemotherapy to attack this trait may radically improve the treatment of advanced disease."--Anticancer Research, January 2015

"Prendergast… and Jaffee…supply basic, translational, and clinical cancer researchers in immunology, biology, and pharmacology with 34 chapters on immunotherapy in cancer treatments. They address new principles of immune suppression in cancer and recent thinking in how immunotherapeutic and chemotherapeutic agents might be combined to defeat mechanisms of tumoral immune suppression and reprogram the inflammatory microenvironment of tumor cells to enhance long-term outcomes."--Reference & Research Book News, December 2013