Cancer Immunotherapy

Cancer Immunotherapy

Immune Suppression and Tumor Growth

1st Edition - June 4, 2007

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  • Editors: George Prendergast, Elizabeth Jaffee
  • eBook ISBN: 9780080521855

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There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This book highlights emerging new principles of immune suppression that drive cancer and it offers radically new ideas about how therapy can be improved by attacking these principles. Following work that firmly establishes immune escape as an essential trait of cancer, recent studies have now defined specific mechanisms of tumoral immune suppression. It also demonstrates how attacking tumors with molecular targeted therapeutics or traditional chemotherapeutic drugs can produce potent anti-tumor effects in preclinical models. This book provides basic, translational, and clinical cancer researchers an indispensable overview of immune escape as a critical trait in cancer and how applying specific combinations of immunotherapy and chemotherapy to attack this trait may radically improve the treatment of advanced disease.

Key Features

* Offers a synthesis of concepts that are useful to cancer immunologists and pharmacologists, who tend to work in disparate fields with little cross-communication
* Drs Prendergast and Jaffee are internationally recognized leaders in cancer biology and immunology who have created a unique synthesis of fundamental and applied concepts in this important new area of cancer research
* Summarizes the latest insights into how immune escape defines an essential trait of cancer
* Includes numerous illustrations including: how molecular-targeted therapeutic drugs or traditional chemotherapy can be combined with immunotherapy to improve anti-tumor efficacy; and how reversing immune suppression by the tumor can cause tumor regression


Basic, translational, and clinical cancer researchers as well as practicing oncologists and their patients

Table of Contents

  • Part I: Principles of Cancer Immunobiology
    Cancer Immunoediting: From Immune Surveillance to Immune Escape
    Immunosurveillance: Innate and Adaptive Anti-Tumor Immunity
    Cytokine Regulation of Immune Tolerance to Tumors
    Immunological Sculpting: Natural Killer Cell Receptors and Ligands
    Immune Escape: Immunosuppressive Networks
    Part II: Cancer Therapeutics
    Cytotoxic Chemotherapy in Clinical Treatment of Cancer
    Targeted Therapeutics in Cancer Treatment
    Concepts in Pharmacology and Toxicology
    Cancer Immunotherapy: Challenges and Opportunities
    Cancer Vaccines
    Part III: Targets and Tactics to Improve Cancer Immunotherapy By Defeating Immune Suppression
    Immunotherapy and Cancer Therapeutics: Why Partner?
    Immune Stimulatory Features of Classical Chemotherapy
    Dendritic Cells and Co-Inhibitory Molecules
    Regulatory T Cells in Tumor Immunity: Role of Toll-like Receptors
    Tumor-associated Macrophages in Cancer Growth and Progression
    Tumor-associated Myeloid-derived Suppressor Cells
    Programmed Death Ligand-1 and Galectin-1: Pieces in the Puzzle of Tumor Immune Escape
    IDO in Immune Escape: Regulation and Therapeutic Inhibition
    Arginase, Nitric Oxide Synthase, and Novel Inhibitors of L-arginine Metabolism in Immune Modulation
    Summary: Future Questions

Product details

  • No. of pages: 428
  • Language: English
  • Copyright: © Academic Press 2007
  • Published: June 4, 2007
  • Imprint: Academic Press
  • eBook ISBN: 9780080521855

About the Editors

George Prendergast

Affiliations and Expertise

Lankenau Institute for Medical Research, Wynnewood, PA, U.S.A.

Elizabeth Jaffee

Affiliations and Expertise

Department of Oncology, SKCCC, Johns Hopkins University, Baltimore, MD, U.S.A.

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