COVID-19 Update: We are currently shipping orders daily. However, due to transit disruptions in some geographies, deliveries may be delayed. To provide all customers with timely access to content, we are offering 50% off Science and Technology Print & eBook bundle options. Terms & conditions.
Cancer Immunotherapy - 1st Edition - ISBN: 9780123725516, 9780080521855

Cancer Immunotherapy

1st Edition

Immune Suppression and Tumor Growth

0.0 star rating Write a review
Editors: George Prendergast Elizabeth Jaffee
Hardcover ISBN: 9780123725516
eBook ISBN: 9780080521855
Imprint: Academic Press
Published Date: 4th June 2007
Page Count: 428
Sales tax will be calculated at check-out Price includes VAT/GST
Price includes VAT/GST

Institutional Subscription

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.


There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This book highlights emerging new principles of immune suppression that drive cancer and it offers radically new ideas about how therapy can be improved by attacking these principles. Following work that firmly establishes immune escape as an essential trait of cancer, recent studies have now defined specific mechanisms of tumoral immune suppression. It also demonstrates how attacking tumors with molecular targeted therapeutics or traditional chemotherapeutic drugs can produce potent anti-tumor effects in preclinical models. This book provides basic, translational, and clinical cancer researchers an indispensable overview of immune escape as a critical trait in cancer and how applying specific combinations of immunotherapy and chemotherapy to attack this trait may radically improve the treatment of advanced disease.

Key Features

  • Offers a synthesis of concepts that are useful to cancer immunologists and pharmacologists, who tend to work in disparate fields with little cross-communication
  • Drs Prendergast and Jaffee are internationally recognized leaders in cancer biology and immunology who have created a unique synthesis of fundamental and applied concepts in this important new area of cancer research
  • Summarizes the latest insights into how immune escape defines an essential trait of cancer
  • Includes numerous illustrations including: how molecular-targeted therapeutic drugs or traditional chemotherapy can be combined with immunotherapy to improve anti-tumor efficacy; and how reversing immune suppression by the tumor can cause tumor regression


Basic, translational, and clinical cancer researchers as well as practicing oncologists and their patients

Table of Contents

Part I: Principles of Cancer Immunobiology Introduction Cancer Immunoediting: From Immune Surveillance to Immune Escape Immunosurveillance: Innate and Adaptive Anti-Tumor Immunity Cytokine Regulation of Immune Tolerance to Tumors Immunological Sculpting: Natural Killer Cell Receptors and Ligands Immune Escape: Immunosuppressive Networks

Part II: Cancer Therapeutics Cytotoxic Chemotherapy in Clinical Treatment of Cancer Targeted Therapeutics in Cancer Treatment Concepts in Pharmacology and Toxicology Cancer Immunotherapy: Challenges and Opportunities Cancer Vaccines

Part III: Targets and Tactics to Improve Cancer Immunotherapy By Defeating Immune Suppression Immunotherapy and Cancer Therapeutics: Why Partner? Immune Stimulatory Features of Classical Chemotherapy Dendritic Cells and Co-Inhibitory Molecules Regulatory T Cells in Tumor Immunity: Role of Toll-like Receptors Tumor-associated Macrophages in Cancer Growth and Progression Tumor-associated Myeloid-derived Suppressor Cells Programmed Death Ligand-1 and Galectin-1: Pieces in the Puzzle of Tumor Immune Escape IDO in Immune Escape: Regulation and Therapeutic Inhibition Arginase, Nitric Oxide Synthase, and Novel Inhibitors of L-arginine Metabolism in Immune Modulation Summary: Future Questions


No. of pages:
© Academic Press 2007
4th June 2007
Academic Press
Hardcover ISBN:
eBook ISBN:

About the Editors

George Prendergast

Affiliations and Expertise

Lankenau Institute for Medical Research, Wynnewood, PA, U.S.A.

Elizabeth Jaffee

Affiliations and Expertise

Department of Oncology, SKCCC, Johns Hopkins University, Baltimore, MD, U.S.A.


This relatively compact book is a summary of contemporary thinking about cancer immunotherapy, with a focus on the relationship between tumors and the immune response of the host. The book is edited by authorities on tumor biology and cancer immunotherapy and reflects the nascent synthesis of these disciplines. The chapters are written by highly respected investigators, and the topics span much of the breadth and depth of this evolving field. The book seems designed to provide an overview for those who wish to immerse themselves in this field and who have a working knowledge of immunotherapy but rudimentary familiarity with cancer immunobiology and therapy. - The New England Journal of Medicine, April 2008

Ratings and Reviews