Description

Cancer Drug Design and Discovery, Second Edition is an important reference on the underlying principles for the design and subsequent development of new anticancer small molecule agents. New chapters have been added to this edition on areas of particular interest and therapeutic promise, including cancer genomics and personalized medicine, DNA-targeted agents and more. This book includes several sections on the basic and applied science of cancer drug discovery and features those drugs that are now approved for human use and are in the marketplace, as well as those that are still under development. By highlighting some of the general principles involved in taking molecules through basic science to clinical development, this book offers a complete and authoritative reference on the design and discovery of anticancer drugs for translational scientists and clinicians involved in cancer research.

Table of Contents

Introduction

Cancer Drug Design and Discovery

Foreword

Editor Biography

Contributors

Part I: Basic Principles and Methodology

Chapter 1. Modern Cancer Drug Discovery: Integrating Targets, Technologies, and Treatments for Personalized Medicine

Abstract

Acknowledgments

Introduction: Changing Times

Successes and Limitations

Integrated Small-Molecule Drug Discovery and Development

New Molecular Targets: The Druggable Cancer Genome and Epigenome

From Drug Target to Development Candidate

Examples of Case Histories for Molecularly Targeted Cancer Therapeutics

Biomarkers, the Pharmacological Audit Trail, and Clinical Development

Conclusions and Outlook: Toward Individualized Molecular Cancer Medicine

Disclosure

References

Recommended further reading

Useful Websites

Chapter 2. Pharmacogenomics and Personalized Medicines in Cancer Treatment

Abstract

Introduction

Molecular Genetic Basis for Variation in Drug Response

Methodologies for Pharmacogenomic Discovery, Validation, and Implementation

Clinically Important Pharmacogenomic Markers for Treatment Response

Conclusions

References

Chapter 3. Natural Product Chemistry and Cancer Drug Discovery

Abstract

Acknowledgments

Introduction

Exemestane (Aromasin)

Fulvestrant (Faslodex)

Flavonoids

Bexarotene (Targretin)

Epothilones

Maytansine

Geldanamycin

UCN-01

Camptothecin

Prodigiosin

Azacitidine

FK-228

Hemiasterlin

Halichondrin

Trabectedin

Conclusions

References

Chapter 4. Structural Biology and Anticancer Drug Design

Abstract

Introduction

Structural Biology Methods

Structural Biology and Structure-Based Drug

Details

No. of pages:
640
Language:
English
Copyright:
© 2014
Published:
Imprint:
Academic Press
eBook ISBN:
9780123972286
Print ISBN:
9780123965219

Reviews

"…offers unique information on the discovery and design of new anticancer agents, covering recent notable successes resulting from the human genome and cancer genomics projects…an excellent reference for translational researchers interested in cancer biology and medicine as well as students in pharmacy, pharmacology, or medicinal and biological chemistry…"--Anticancer Research 34, 2014
"The second edition of this book walks readers through the myriad cancer drugs and their molecular targets, with a special emphasis on past, present, and future drug design efforts... the book examines both drugs currently in the clinic and those merely on the drawing board…This comprehensive update of the 2008 edition will serve student or experienced cancer researchers well as a reference on anticancer drug development." Rating: 4 Stars--Doody.com, March 21, 2014
"Specialists in cancer and pharmaceuticals, most in academic settings, look at basic principles of cancer drugs, methodology, drugs in the clinic, new agents, and the reality of cancer drugs in the clinic…They do include many case studies, and some chapters provide questions for classroom use."--ProtoView.com, February 2014