Cancer and Noncoding RNAs - 1st Edition - ISBN: 9780128110225

Cancer and Noncoding RNAs, Volume 1

1st Edition

Editors: Jayprokas Chakrabarti Sanga Mitra
Series Editors: Trygve Tollefsbol
Hardcover ISBN: 9780128110225
Imprint: Academic Press
Published Date: 1st October 2017
Page Count: 464
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Table of Contents

SECTION I: Genetic and Epigenetic effect on cancer through noncoding RNA
1. miRNA and Cancer
2. miRNA biogenesis disruption and cancer
3. Genetic alteration of miRNA affecting cancer pathways
4. The Epigenetic Control of MicroRNA Expression and Cancer
5. Effects of miRNAs on epigenetic machinery
6. Histone modifiers of deregulated miRNAs in cancer
7. miRNA genes epigenetically regulated by DNA methylation in cancer
8. Circulating miRNA increasing the risk of cancer
9. lncRNA as cancer biomarker
10. Genetic variation of lncRNA in cancer
11. Implications of lncRNAs in cancer epigenetics
12. Charting DNA methylation of long non-coding RNA in cancer.
13. Competing endogenous RNA and cancer
14. miRNA-lncRNA-ceRNA network in cancer
15. Noncoding function of protein-coding genes: mRNA 3´ UTR as ceRNAs in cancer
16. Long noncoding RNAs and pseudogenes as ceRNA in cancer
17. Epigenetic programming mechanism guided by piRNAs in cancer
18. Epigenetic loss of the PIWI/piRNA machinery in human tumorigenesis
19. tRNA and cancer
20. Dynamic Reprogramming of tRNA Modifications in Cancer
21. Post-transcriptional modifications of tRNA linked to cancer
22. Circular RNA: a novel non-coding RNA in Cancer
23. Other ncRNA and cancer

SECTION II: Cancer Epigenetic Mechanism modulated by non-coding RNA
24. Assessing DNA Methylation and Demethylation of noncoding RNA in cancer
25. Noncoding RNAs act as chromatin Scaffold of Histone Modification Complexes in cancer
26. Heterochromatin modulation by noncoding RNA in cancer
27. Noncoding RNAs (ncRNAs) mediate the recruitment of PcG control of gene expression in cancer

SECTION III: Therapeutic implications of ncRNA in cancer
28. Non-coding RNA involved in Cancer Stem Cell Therapy
29. Therapeutic strategies based on targeting ncRNAs for selective silencing
30. Clinical Relevance of non-coding RNA in Cancer
31. Non-coding RNAs: Novel Targets in anticancer drug development

SECTION V: Bioinformatics’ detection of ncRNA in cancer
32. Cancer ncRNA discovery via High Throughput Sequencing
33. Non-coding RNAs as a cause of cancer: evidence from GWAS and reverse genetics
34. A comparative evaluation of emerging tools for cancer ncRNA retrieval
35. Databases: a comprehensive resource of noncoding RNAs


Description

Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer. In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and tRNAs, identifying differences in function between these noncoding RNAs and how they interact with the rest of the epigenome. A broad range of chapters from experts in the field detail epigenetic regulation of various cancer types, along with recent next generation sequencing technologies, genome-wide association studies (GWAS) and bioinformatics approaches.

This book will help researchers in genomic medicine and cancer biology better understand the role of noncoding RNAs in epigenetics, aiding in the development of useful biomarkers for diagnosis, prognosis and new RNA-based disease therapies.

Key Features

  • Provides a comprehensive analysis of noncoding RNAs implicated in epigenetic regulation of gene expression and chromatin dynamics
  • Educates researchers and graduate students by highlighting, in addition to miRNAs, a range of noncoding RNAs newly associated with carcinogenesis
  • Applies current knowledge of noncoding RNAs and epigenomics towards developing cancer and RNA-based disease therapies
  • Features contributions by leading experts in the field

Readership

Researchers, clinicians and graduate students in genomic medicine, epigenetics, and cancer research with an interest in developing RNA-based disease therapies


Details

No. of pages:
464
Language:
English
Copyright:
© Academic Press 2018
Published:
Imprint:
Academic Press
Hardcover ISBN:
9780128110225

About the Editors

Jayprokas Chakrabarti Editor

Dr. Chakrabarti earned his PhD from the City University of New York. He conducted postdoctoral training at University of Rochester, New York; the Institute of Theoretical Science in Eugene, Oregon; and the University of Bielefeld, Germany. Currently he is a Senior Lecturer at the Indian Association for the Cultivation of Science (IACS) in Kolkata, India and a Principle Investigator at Gyanxet-Beta, a commercial lab which develops tools and resources for RNA bioinformatics. Dr. Chakrabarti’s research areas include the role of noncoding RNAs in human disease, specifically in viral infections and head and neck cancer, as well as stem cells and pluripotency and the development of bioinformatics tools for analyzing noncoding RNAs. He has more than fifteen years of research experience in epigenetics, focusing on noncoding RNAs, and more than twenty-five years teaching experience at IACS. In addition to his teaching and research, Dr. Chakrabarti has published more than fifty scientific papers in peer reviewed journals and has served on the editorial boards of Scientific Reports, Bioinformatics, Journal of Biomolecular Structure and Dynamics, Nucleic Acids Research, DNA Research, Human Mutations, PLOS Computational Biology, and BMC Genomics. His lab at IACS has collaborated on epigenetic research with labs at the Massachusetts Institute of Technology, University of Georgia, Stanford University, and the University of Bielefeld, among others.

Affiliations and Expertise

Senior Lecturer, Indian Association for the Cultivation of Science (IACS), Kolkata, India; Principle Investigator, Gyanxet-Beta, Kolkata, India

Sanga Mitra Editor

Since 2010 Sanga Mitra has served as a Senior Research Fellow at the Indian Association for the Cultivation of Science (IACS) in Kolkata, India, under the mentorship of her PhD advisor, Jayprokas Chakrabarti. Her research areas within the Computational Biology group at IACS include microarray and RNA-Sequencing data analysis, histone modifications, head and neck cancer, and tRNA gene annotation. She holds an M.S. in Bioinformatics and has recently submitted her PhD dissertation, “Computational Genomics and miRNomics of Cancer.” Sanga Mitra has also presented on her research at genomics, cancer, and bioinformatics conferences around the world, most notably at BIT’s 3rd World DNA and Genome Day, New Horizons in Cancer Research, and the International Conference on Stem Cells and Cancer. She has published eight scientific papers to-date in peer reviewed journals including RNA and Transcription, Journal of Biomolecular Structure and Dynamics, Scientific Reports, Genomic Medicine, and Cancer Biomarkers.

Affiliations and Expertise

Ph.D., Visiting Fellow, NIH-NIDDK/LCMB, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Betheda, MD, USA

About the Series Editors

Trygve Tollefsbol Series Editor

Trygve Tollefsbol is a Professor of Biology and a Senior Scientist in the Comprehensive Center for Healthy Aging, the Comprehensive Cancer Center, the Nutrition Obesity Research Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999. Dr. Tollefsbol has doctorate degrees in molecular biology and osteopathic medicine and has edited and co-authored numerous books on the topics of epigenetics, cancer and aging and is Series Editor of Translational Epigenetics. Dr. Tollefsbol is a Professor of Biology and a Senior Scientist in the Center for Aging, Comprehensive Cancer Center, Nutrition Obesity Research Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999 and a Steering Committee Member of the UAB Center for Aging. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor’s degree in Biology from the University of Houston. He has received prior funding from the NIA, NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources. The Glenn Foundation for Medical Research funding was unsolicited and was awarded to Dr. Tollefsbol for lifetime contributions to the field of aging. In 2006 Dr. Tollefsbol was selected and highlighted as part of the 25th anniversary of the AFAR for significant contributions to aging research. Dr. Tollefsbol’s research interests have covered a wide range of topics such as aging, epigenetics, nutrition, cancer, telomerase, and caloric restriction. Work from his laboratory has been featured in Women’s Health magazine, Shape magazine, and the AICR Newsletter and Dr. Tollefsbol has been a Scientist in the Spotlight in ScienceNow. Currently he serves as an Associate Editor for Frontiers in Epigenomics and is on the Editorial Boards of the international journals Open Longevity Science, Epigenetics of Diabetes and Obesity, Molecular Biotechnology and Clinical Epigenetics. He is also a contributing Editor of Lewin’s GENES X classic textbook. Over 25 of the publications from Dr. Tollefsbol’s laboratory have received national or international accolades such as best paper award, selection for press release by the journal editors and featured on the journal homepage. Dr. Tollefsbol has been invited to give presentations on his research in many countries including Germany, China, Italy, Switzerland, France and The Netherlands as well as at various leading institutions in the US such as Harvard Medical School, Tufts University and the University of California at San Francisco. His research has received considerable media attention both nationally and internationally through television, newspaper and radio venues and has been highlighted in eScience News and ScienceDaily. He has ten books which have been published or are in progress and a recent book on “Epigenetics of Aging” that Dr. Tollefsbol co-authored and edited was highlighted in Nature.

Affiliations and Expertise

Professor of Biology, Director of the Cell Senescence Culture Facility, University of Alabama at Birmingham, AL, USA