Cancer and Autoimmunity

1st Edition

Editors: M.E. Gershwin Yehuda Shoenfeld
Hardcover ISBN: 9780444503312
eBook ISBN: 9780080528458
Imprint: Elsevier Science
Published Date: 27th March 2000
Page Count: 468
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Of the two disciplines in parallel development for two decades, tumor immunology and transplantation immunology, the latter has thrived and has led to some of the most critical discoveries in immunobiology. The former continues to thwart both scientists and clinicians alike.
The goal of immunologists in modern day research is to develop a simple and effective means to manipulate cancer in vivo, possibly encompassing several venues: identifying a phenotypic marker and the use of either active or passive immunization; include the use of passive reagents carrying "warheads" to selectively destroy cancer cells; or altering the basic process of cell survival.
This excellent multidiscipline-authored volume presents a theme which has not been well described before. The papers include both basic and clinical science and range from sophisticated molecular biology to little more than phenomenology (e.g. the increased association of cancer in some autoimmune diseases and increased presentation of autoimmune phenomena in malignant condition). This, however, is state-of-the-art.
This collection of themes will be of use not only to bench scientists, but also to clinicians who treat patients. The book represents progress at the cutting edge of this discipline, and points the way to further developments in the "black box" of immunology.

Table of Contents

Preface. List of Contributors. Introduction: The Immune System, the Autoimmune State and Autoimmune Disease (Jacob George, Yehuda Shoenfeld).
Chapter I: Malignancies in Autoimmune Diseases. 1. Rheumatoid Arthritis and Cancer (Mahmoud Abu-Shakra, Dan Buskila, Yehuda Shoenfeld). 2. SLE and Cancer (Mahmoud Abu-Shakra, Dan Buskila, Yehuda Shoenfeld). 3. Malignancies Occurring in Scleroderma (Pascal Godmer, Loïc Guillevin). 4. PSS (Scleroderma) and Cancer (Anabel Aron-Maor, Yehuda Shoenfeld). 5. Vasculitis and Malignancy (Efstratios Tatsis, Wolfgang L. Gross). 6. Sjögren's Syndrome and Lymphoproliferative Disease (Manel Ramos-Casals, Mario García-Carrasco, Josep Font, Richard Cervera). 7. Polymyalgia Rheumatica, Temporal Arthritis and Occurrence of Malignant Tumors (Jozef Rovenský, Alena Tuchyňová). 8. Myositis and Neoplasia (Claire Fieschi, Jean-Charles Piette). 9. Antiphospholipid Antibodies and Malignancies (Ronald A. Asherson, R. Cervera). 10. Malignancy in Coeliac Disease and Dermatitis Herpetiformis (Helena Tlaskalová, Ludmila Tučková, Miloslav Pospišil, Renata Štěpánková). 11. Autoimmune Rheumatic Diseases and Cancer: Evidence of Causality? (Antonio R. Villa, Arnoldo Kraus, Donato Alarcón-Segovia).
Chapter II: Autoimmunity in Malignant States.

  1. Paraneoplastic Syndromes (Moshe Tishler, Yehuda Shoenfeld). 2. Paraneoplastic Arthritis (S. Praprotnik, M. Tomšič).
  2. Autoantibodies, Autoimmunity and Cancer (Yaron Tomer, Yehuda Shoenfeld).
  3. Autonuclear Antibodies as Potential Markers of Lung Cancer (F. Fernàndez-Madrid, J. Tomkiel).
  4. Autoantibodies in Cancer Patients and in Persons with a Higher Risk of Cancer Development (Karsten Conrad).
  5. Autoantibodies to the Proliferation-Associated Nuclear Protein CENP-F in Cancer (Carlos Casi


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About the Editor

M.E. Gershwin

Affiliations and Expertise

University of California, Clinical Division of Rheumatology, School of Medicine, Davis, CA, USA

Yehuda Shoenfeld

Prof. Yehuda Shoenfeld is the founder and head of the Zabludowicz Center for Autoimmune Diseases, at the Sheba Medical Center which is affiliated to the Sackler Faculty of Medicine in Tel-Aviv University, in Israel. Dr. Shoenfeld is the Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases at the Tel-Aviv University. His clinical and scientific works focus on autoimmune and rheumatic diseases, and he has published more than 1750 papers in journals such as New Eng J Med, Nature, Lancet, Proc Nat Acad Scie, J Clin Invest, J Immunol, Blood, FASEB, J Exp Med, Circulation, Cancer and others. His articles have had over 35,000 citations. He has written more than three hundred and fifty chapters in books, and has authored and edited 25 books, some of which became cornerstones in science and clinical practice, such as "The Mosaic of Autoimmunity", "Infections and Autoimmunity" and the textbook "Autoantibodies" and "Diagnostic criteria of autoimmune diseases", all of which were published by Elsevier and sold by the thousands. He is on the editorial board of 43 journals in the field of rheumatology and autoimmunity and is the founder and the editor of the IMAJ (Israel Medical Association Journal) the representative journal of science and medicine in the English language in Israel, and also is the founder and Editor of the "Autoimmunity Reviews" (Elsevier) (Impact factor 7.9) and Co-Editor of "Journal of Autoimmunity" (Impact factor 8.1). He has organized over 20 international congresses in autoimmunity. Prof. Shoenfeld received the EULAR prize in 2005, in Vienna, Austria: "The infectious etiology of anti-phospholipid syndrome". He has received a gold medal from the Slovak Society of Physicians for his contribution to Israel – Slovakia collaboration (March 2006), and is honorary member of the Hungarian Association of Rheumatology. In UC Davis, USA, Dr. Shoenfeld received the Nelson's Prize for Humanity and Science for 2008. In 2009 he was honore

Affiliations and Expertise

Zabludowicz Center for Autoimmune Diseases,Sheba Medical Center, Affiliate of Tel-Aviv University, Israel


@from:W.M. Yokoyama, Washington University Medical Center @qu:...A very broad topic that has not received much attention is covered in this volume. This is particularly useful for the clinician who desires a compilation of the literature on association between specific autoimmune diseases and cancer, and vice versa, but also desires coverage of molecular mechanisms and therapy. @source:Doddy's @from:J.E. Naschitz @qu:...I welcome and recommend this book for the delight of the intellectual challenge and for the new horizons it opens. @source:Journal of Clinical Rheumatology