Camptothecin and Camptothecin Producing Plants

Botany, Chemistry, Anticancer Activity and Biotechnology

1st Edition - June 18, 2020
Authors: T. Pullaiah, P.B. Raghavendra, S. Karuppusamy, V. Raveendran, M. Anuradha
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 0 4 9 9 - 3
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 0 9 2 7 - 1

Camptothecin and Camptothecin Producing Plants: Botany, Chemistry, Anticancer Activity and Biotechnology provides updated information on camptothecin yielding plants, chemic… Read more

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Camptothecin and Camptothecin Producing Plants: Botany, Chemistry, Anticancer Activity and Biotechnology provides updated information on camptothecin yielding plants, chemical diversity of camptothecin, extraction and exploitation methods, biosynthesis, biotechnological production and enhancement for drug delivery, and the pharmacological properties of the drugs. The book focuses on camptothecin anticancer properties based on recent developments of biotechnology. Topics emphasize anticancer activities, biosynthesis, potent derivatives currently undergoing experimental phases, and biotechnological methods to enhance the production. This book is a valuable source for cancer researchers, oncologists, biotechnologists, pharmacologists and members of the biomedical field who are interested in camptothecin and its applicability in cancer treatment.

Cover image
Title page
Table of Contents
Copyright
Preface
Abbreviations
Chapter 1. Cancer biology and other disorders: beneficial role of camptothecin and novel derivatives
Abstract
1.1 Introduction
1.2 The principles underlying transformation of normal cells into tumor
1.3 Nuclear transcription factor kappa B
1.4 Programmed cell death-apoptosis
1.5 Targeted cancer therapy
1.6 Molecular mechanisms of drug resistance in cancer
1.7 Strategy to overcome chemoresistance
1.8 Camptothecin
1.9 Conclusions
References
Chapter 2. Camptothecin: chemistry, biosynthesis, analogs, and chemical synthesis
Abstract
2.1 Introduction
2.2 Chemistry of camptothecin
2.3 A historical account on the discovery of camptothecin
2.4 Plant sources of camptothecin
2.5 Factors affecting camptothecin production in plants
2.6 Camptothecin from endophytes
2.7 Biosynthetic pathway
2.8 Extraction of camptothecin
2.9 Clinically useful derivatives of camptothecin
2.10 Analogs of camptothecin under clinical investigation
2.11 Synthetic studies
References
Chapter 3. Camptothecin and analogs: role in anticancer activities
Abstract
3.1 Introduction
3.2 Antitumor effects of camptothecin and analogs in breast cancer
3.3 Antitumor effects of camptothecin and analogs in leukemia disorders
3.4 Antitumor effects of camptothecin and analogs in hepatocellular carcinoma and colorectal cancer
3.5 Antitumor effects of camptothecin and analogs in lung cancer
3.6 Antitumor effects of camptothecin and analogs in glioblastoma multiforme
3.7 Antitumor effects of camptothecin in nasopharyngeal carcinoma
3.8 Antitumor effects of camptothecin nanoparticles
3.9 Enhancement of antitumor effects of camptothecin by combinational therapies
3.10 Conclusions
References
Chapter 4. Botany of camptothecin-yielding plants
Abstract
4.1 Introduction
4.2 Camptothecin-yielding plants
References
Chapter 5. Propagation of camptothecin biosynthesizing plants
Abstract
Abbreviations
5.1 Introduction
5.2 Camptotheca acuminata
5.3 Nothapodytes nimmoniana
5.4 Chonemorpha fragrans
5.5 Ophiorrhiza species
5.6 Apodytes dimidiata
Acknowledgment
References
Patents
Chapter 6. In vitro camptothecin production from plants: prospects and challenges
Abstract
6.1 Introduction
6.2 In vitro camptothecin production
References
Chapter 7. Biomining of camptothecin producing plants through molecular techniques
Abstract
7.1 Introduction
7.2 Enzymes regulating camptothecin biosynthetic pathway and their BLAST search
7.3 Comparative sequence data analysis
7.4 Identification of candidate gene involved in camptothecin synthesis
7.5 Prospecting phylogenetically related species of Nothapodytes nimmoniana for camptothecin production
7.6 Phylogenetic relationship of genus Ophiorrhiza and their camptothecin producing ability
7.7 Molecular dynamics simulations from camptothecin producing plants on DNA topoisomerses I
7.8 Camptothecin production of C. acuminata and their relatives through phylogenetic analysis
7.9 Molecular mechanism of camptothecin synthesis in Camptotheca acuminata
7.10 Molecular relationship of Dysoxylum gotadhora with alkaloid producing Rubiaceae members
7.11 Phylogenetic relationship of CPT-producing Icacinaceae
References
Chapter 8. Endophytes and camptothecin production
Abstract
8.1 Introduction
8.2 Fungal endophytes
8.3 Fungal strains and attenuation of camptothecin production
8.4 Bacterial endophytes
References
Index

T. Pullaiah

Professor T. Pullaiah is a former Professor at the Department of Botany at Sri Krishnadevaraya University in Andhra Pradesh, India, where he has taught for more than 35 years. He was President of Indian Botanical Society (2014), President of the Indian Association for Angiosperm Taxonomy (2013). He was awarded the Panchanan Maheshwari Gold Medal, the Prof. P.C.Trivedi Medal, the Dr. G. Panigrahi Memorial Lecture award of the Indian Botanical Society and Prof. Y.D. Tyagi Gold Medal of the Indian Association for Angiosperm Taxonomy. Under his guidance 54 students obtained their doctoral degrees. He has authored 52 books, edited 23 books and published over 330 research papers, including reviews and book chapters. He was also a member of Species Survival Commission of the International Union for Conservation of Nature (IUCN). Professor Pullaiah received his PhD from Andhra University, India, attended Moscow State University, Russia, and worked as Post-Doctoral Fellow

Affiliations and expertise

Department of Botany, Sri Krishnadevaraya University, Anantapur, India

P.B. Raghavendra

Dr. P.B. Raghavendra is currently affiliated with School of Regenerative Medicine, Manipal University, Bangalore, India, and has served as Director of School of Chemical and Biological Sciences, REVA University. He is the author of Book Advances in Cell and Molecular Diagnostics and a number of articles and book chapters on various aspects of medical sciences and life sciences published in International journals. He is a visiting professor and technology consultant for many universities and biotechnology companies.

Affiliations and expertise

School of Regenerative Medicine, Manipal University, Bangalore, India

S. Karuppusamy

Dr. S. Karuppusamy is currently affiliated with the Department of Botany, The Madura college, Madurai, India. He was Post Doctoral Fellow at Sri Krishnadevaraya University. He has published 10 books and 120 research papers. He was awarded Prof. Y.S.Murthy Gold Medal from Indian Botanical Society.

Affiliations and expertise

Department of Botany, The Madura College, Madurai, India

V. Raveendran

Dr. V. Raveendran is working as Associate Scientist, Cardiovascular Research Program, King Faisal Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia. He was a Post-Doctoral fellow at Department of Internal Medicine, University of Kansas Medical Center, Kansas, USA.

Affiliations and expertise

Associate Scientist, Department of Cell Biology, King Faisal Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia

M. Anuradha

Dr. M. Anuradha is currently affiliated to Padmashree Institute of Management and Sciences, Bangalore, India. She was scientist at Dr. Reddy’s research foundation, Hyderabad, India and Sami Labs Pvt. Ltd. Bangalore, India. She published one book and more than 30 papers in national and international journals and co- author for book chapters. She also filed 6 Indian patents and has one US patent granted. She successfully completed four research projects on camptothecin yielding plants supported by Department of Science and Technology, New Delhi and National Medicinal Plants Board, New Delhi and consultant to private herbal companies dealing with camptothecin.

Affiliations and expertise

Institute of Management and Sciences, Bangalore, India