This book focuses on emerging themes in the molecular mechanisms of calcium signal transduction through calmodulin-regulated pathways. It provides the reader with selected examples and experimental precedents that underlie current models of cell regulation through calmodulin-regulated pathways and their linkage with other regulatory pathways.

Key Features

@introbul:Highlights: @bul:* Molecular mechanisms of calcium signal transduction through calmodulin-regulated enzymes * Selected case studies and precedents related to molecular mechanisms * Protein-protein recognition between calmodulin and the enzymes it regulates * Cross-talk and interdigitation with other signal transduction pathways


Molecular biologists and cell biologists interested in signal transduction and cytoskeleton. Biochemists and chemists interested in protein–protein interactions. Cell physiologists, neuroscientists, medical students, and graduate students in biomedical sciences.

Table of Contents

L.J. Van Eldik and D.M. Watterson, Calmodulin and Calcium Signal Transduction: An Introduction. M.R. Nelson and W.J. Chazin, Calmodulin as a Calcium Sensor. T.J. Lukas, S. Mirzoeva, and D.M. Watterson, Calmodulin-Regulated Protein Kinases. B.A. Perrino and T.R. Soderling, Biochemistry and Pharmacology of Calmodulin-Regulated Phosphatase Calcineurin. W.K. Sonnenburg, G.A. Wayman, D.R. Storm, and J.A. Beavo, Cyclic Nucleotide Regulation by Calmodulin. J. Hu and L.J. Van Eldik, Regulation of Nitric Oxide Synthase by Calmodulin. N.M. Bonafe and J.R. Sellers, Calmodulin-Binding Proteins of the Cytoskeleton. P.C. Brandt and T.C. Vanaman, Calmodulin and Ion Flux Regulation. Subject Index.


No. of pages:
© 1998
Academic Press
Print ISBN:
Electronic ISBN:

About the authors

Linda Van Eldik

Affiliations and Expertise

Northwestern University Medical School, Chicago, Illinois, U.S.A.

D. Watterson

Affiliations and Expertise

Northwestern University Medical School, Chicago, Illinois, U.S.A.


@qu:" can be heartily recommended for new investigators entering the field. The volume is an admirable resources and it deserves to be highly successful." @source:--TRENDS IN CELL BIOLOGY @qu:"...this is the first time that an attempt has been made to provide the readers with a more extended background with selected examples and experimental procedures underlying the current models of this regulatory mechanisms, all of the highest interest... All the papers have been masterly presented, clearly written and are of a rich content where any of us will discover many interesting aspects, so that all cellular and molecular biologists will be interested at the first degree in such presentations." @source:--CELLULAR AND MOLECULAR BIOLOGY @qu:"This is an exceptional discussion of calmodulin and the signaling events it mediates. In particular, the text excels in coverage of calmodulin-regulated protein kinases." @source:--DOODY'S PUBLISHING REVIEWS