Calcium and Cell Function

Calcium and Cell Function

Volume 3

1st Edition - January 28, 1983

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  • Editor: Wai Yiu Cheung
  • eBook ISBN: 9781483217482

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Calcium and Cell Function, Volume III covers the many aspects of research on calcium, dealing with its biochemistry, biology, and pharmacology in animals as well as in plants. The book discusses a novel cellular signaling system based on the integration of phospholipid and calcium metabolism; the transport of calcium by sarcoplasmic reticulum; and the energetics and chemistry for interactions between calmodulin and calmodulin-binding proteins. The text also describes the specificity of trifluoperazine and related phenothiazines for calcium-binding proteins; the structure, function, and regulation of phosphorylase kinase; and the regulation of glycogen synthase by multiple protein kinases. The role of calmodulin in synaptic function and neurosecretion; the stimulation of the synthesis of neurotransmitters by calmodulin-dependent phosphorylation; as well as the role of calcium in axoplasmic transport in nerve are also considered. The book further tackles calcium control of the intestinal microvillus cytoskeleton; the possible role of calmodulin in the regulation of insulin release and protein phosphorylation by calcium and cyclic AMP; and the role of calcium in mediating cellular functions important for growth and development in higher plants. The text also looks into the localization of calmodulin in tissue culture cells; and the characterization and regulation of calcium-dependent neutral protease. Zoologists, cell biologists, biochemists, and pharmacologists will find the book invaluable.

Table of Contents

  • Contributors


    Contents of Previous Volumes

    Chapter 1 A Novel Cellular Signaling System Based on the Integration of Phospholipid and Calcium Metabolism

    I. Introduction

    II. Agonist-Dependent Phospholipid Metabolism

    III. Role of Calcium in Regulating Phospholipid Metabolism

    IV. The Role of Agonist-Dependent Phospholipid Metabolism

    V. Conclusion


    Chapter 2 The Transport of Calcium by Sarcoplasmic Reticulum

    I. Introduction

    II. Structure of Membranes Participating in Excitation-Contraction Coupling

    III. Protein Composition of Sarcoplasmic Reticulum

    IV. Lipids of Sarcoplasmic Reticulum

    V. Mechanism of ATP Hydrolysis and Ca2+ Transport

    VI. Protein-Protein Interactions in Sarcoplasmic Reticulum

    VII. Permeability of Sarcoplasmic Reticulum

    VIII. Relationship between Membrane Potential and Calcium Transport by the Sarcoplasmic Reticulum

    IX. Transport of Calcium by Cardiac Sarcoplasmic Reticulum

    X. Sarcoplasmic Reticulum in Fast-Twitch and Slow-Twitch Skeletal Muscles

    XI. Biosynthesis of Sarcoplasmic Reticulum

    XII. Sarcoplasmic Reticulum in Diseased Muscle


    Chapter 3 The Energetics and Chemistry for Interactions between Calmodulin and Calmodulin-Binding Proteins

    I. Chemistry of Calmodulin Interactions with Calmodulin-Binding Proteins

    II. Energetics of Calmodulin Binding to Calmodulin-Binding Proteins


    Chapter 4 Specificity of Trifluoperazine and Related Phenothiazines for Calcium-Binding Proteins

    I. Introduction

    II. Mode of Binding of Phenothiazines to Calmodulin

    III. Selectivity of Calmodulin for Phenothiazines and Related Antipsychotic Agents

    IV. Site of Action of Phenothiazines as Calmodulin Antagonists

    V. Selectivity of Phenothiazines for Calmodulin

    VI. Other Effects of Phenothiazines

    VII. Conclusions


    Chapter 5 Structure, Function, and Regulation of Phosphorylase Kinase

    I. Historical Background

    II. Purification

    III. General Structure

    IV. Structure and Function of the Subunits

    V. Phosphorylase Kinase from Other Sources


    Chapter 6 Regulation of Glycogen Synthase by Multiple Protein Kinases

    I. Introduction

    II. Glycogen Synthase Structure

    III. Phosphorylation by Specific Kinases in Vitro

    IV. Relationship of Synthase Activity to Phosphorylation State

    V. Glycogen Synthase Phosphatase

    VI. Hormonal Regulation of Synthase


    Chapter 7 Actomyosin of Smooth Muscle

    I. Introduction

    II. Contractile Apparatus

    III. Regulation of Contractile Activity

    IV. Evidence for and against the Phosphorylation Theory

    V. Summary of the Regulatory Process in Smooth Muscle


    Chapter 8 Calmodulin in Synaptic Function and Neurosecretion

    I. Introduction

    II. Synaptic Calmodulin

    III. Calmodulin and Ca2+-Dependent Neurotransmitter Release

    IV. Ca2+-Calmodulin-Stimulated Synaptic Protein Phosphorylation

    V. Evidence Suggesting That Synaptic Ca2+ and Calmodulin-Stimulated Protein Phosphorylation Mediates Ca2+-Dependent Neurotransmitter Release

    VI. Ca2+-Calmodulin Synaptic Vesicle and Synaptic Membrane Interactions

    VII. Ca2+-Calmodulin Tubulin Kinase System in Synaptic Modulation

    VIII. A Molecular Approach to Neurotransmission


    Chapter 9 Stimulation of Synthesis of Neurotransmitters by Calmodulin-Dependent Phosphorylation

    I. Introduction

    II. Activation of Tryptophan Hydroxylase by a Calmodulin-Dependent Phosphorylation Reaction

    III. Possible Role for Calmodulin in the Activation of Tyrosine Hydroxylase by Phosphorylating Conditions

    IV. Existence of Ca2+-Calmodulin-Dependent Tryptophan or Tyrosine Hydroxylase Kinase in Brain

    V. Summary


    Chapter 10 The Role of Calcium in Axoplasmic Transport in Nerve

    I. Properties of Axoplasmic Transport

    II. Dependence of Transport on Ca2+

    III. Partial Sustaining Effect of Mg2+ on Transport

    IV. Transport of Ca2+

    V. Properties of Calcium-Binding Protein

    VI. Isolation of Calmodulin from Mammalian Nerve

    VII. Calcium and the Mechanism of Fast Axoplasmic Transport

    VIII. Regulation of Ca2+ in Nerve


    Chapter 11 Calcium Control of the Intestinal Microvillus Cytoskeleton

    I. Introduction

    II. Microvillus Calmodulin

    III. Calcium Sensitivity of Microvillus Core Filaments

    IV. Villin

    V. Other Major Structural Proteins of the Core Filament Bundle

    VI. Relationship of the Brush Border Cytoskeleton to the Vitamin D-Regulated Calcium Uptake System

    VII. Do Microvilli Move ?


    Chapter 12 Regulation of Insulin Release and Protein Phosphorylation by Calcium and Cyclic AMP: Possible Role for Calmodulin

    I. Introduction

    II. Role of Calcium and Cyclic AMP in Insulin Release

    III. Protein Phosphorylation in Hamster Insulinoma Cells

    IV. Possible Role for Calmodulin in Insulin Release

    V. Summary


    Chapter 13 Role of Calcium in Mediating Cellular Functions Important for Growth and Development in Higher Plants

    I. Introduction

    II. Calcium Uptake, Transport, and Distribution

    III. Cellular Level Functions Mediated by Calcium

    IV. Calcium and Plant Tropisms

    V. Conclusion


    Chapter 14 Localization of Calmodulin in Tissue Culture Cells

    I. Introduction

    II. Calmodulin Antibody: Detection of Occupied Cellular Acceptor Proteins

    III. Fluorescent Calmodulin: Detection of Unoccupied Cellular Acceptor Proteins

    IV. Calmodulin Acceptor Proteins: Purification and Localization

    V. Epilogue


    Chapter 15 Calcium-Dependent Neutral Protease: Its Characterization and Regulation

    I. Introduction

    II. Purification and Characterization

    III. Role of Calcium Ion

    IV. Substrate Specificity

    V. Conversion of m-CANP to μ-CANP

    VI. Endogenous Inhibitor

    VII. Exogenous Inhibitor and Muscle Dystrophy

    R eferences


Product details

  • No. of pages: 526
  • Language: English
  • Copyright: © Academic Press 1983
  • Published: January 28, 1983
  • Imprint: Academic Press
  • eBook ISBN: 9781483217482

About the Editor

Wai Yiu Cheung

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