This volume draws together studies on the diverse group of calcium-activated chloride channels (CaCCS) in one comprehensive format. The characteristics of CaCCs identified in a number of different systems are described by experts in the field. Channels discussed include those described in cardiac, neuronal, endothelial and epithelial systems, in addition to sections on the CaCC of Xenopus Oocytes and the newly identified family of CLCA proteins.

Key Features

@introbul:Key Features @bul:* Includes description of CaCCs in excitable and non-excitable tissues * Reviews identification and cloning of the CLCA protein family * Contains section on CaCCs in Xenopus Oocytes


Cell biologists, biochemists, molecular biologists, electrophysiologists, biophysicists, membrane transport physiologists, tumor and cell biologists, researchers working on epithelial chloride transport, and researchers working on cardiac and somatosensory physiology.

Table of Contents

Dedication Preface SECTION 1: CaCCs in XENOPUS OOCYTES The Endogenous Calcium-Activated Cl Channel in Xenopus Oocytes: A Physiologically and Biophysically Rich Model System. Ca2+-Inactivated Cl- Channels in Xenopus laevis Oocytes. SECTION 2: Ca2+-ACTIVATED Cl- CURRENTS IN EXCITABLE TISSUES A Ca2+-Activated Anion Channel in the Sarcoplasmic Reticulum of Skeletal Muscle. Physiological Role of the Ca2+ - activated Cl- Current in Mammalian Heart. Recent Advances on the Properties and Role of Ca2+-activated Chloride Currents in Smooth Muscle. The Calcium-activated Chloride Conductance in Olfactory Receptor Neurons. Ca2+-activated Cl- Channels as Ca2+-Sensors with Particular Reference to the Modulation of Neuronal Excitability. Determination of Intracellular Chloride Concentration in Dorsal Root Ganglion Neurons by Fluorescence Lifetime Imaging. SECTION 3: Ca2+-ACTIVATED Cl- CURRENTS IN NON-EXCITABLE TISSUES Calcium-activated Cl- Conductance in the Airway Epithelium. Ca2+-activated Cl- Currents in Salivary and Lacrimal Glands. Properties and Role of Calcium-activated Chloride Channels in Pancreatic Duct Cells. Calcium-Mediated Chloride Secretion in the Intestinal Epithelium: Significance and Regulation. Renal Expression of Ca2+-activated Cl- Channels. Calcium-dependent Anion Secretion in Endometrial Epithelial Cells. Calcium-activated Chloride Channels in Vascular Endothelial Cells.. Regulation of Calcium-activated Chloride Channels by Inositol 3,4,5,6-Tetrakisphosphate. SECTION 4: THE CLCA FAMILY Discovery and Cloning of t


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© 2002
Academic Press
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About the serial-volume-editor

Catherine Fuller

C.R. Fuller is the Roanoke Electric Steel Professor of Mechanical Engineering at the Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.

Affiliations and Expertise

Virginia Polytechnic Institute & State University