Brenner and Rector's The Kidney, 2-Volume Set - 10th Edition - ISBN: 9781455748365, 9780323296960

Brenner and Rector's The Kidney, 2-Volume Set

10th Edition

Authors: Karl Skorecki Glenn Chertow Philip Marsden Maarten Taal Alan Yu
eBook ISBN: 9780323296960
eBook ISBN: 9780323262590
Hardcover ISBN: 9781455748365
Imprint: Elsevier
Published Date: 28th October 2015
Page Count: 2748

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Overcome the toughest clinical challenges in nephrology with Brenner & Rector’s The Kidney -- the most well-known nephrology resource in the world. A diverse team of more than 200 international contributors brings you the latest knowledge and best practices on every front in nephrology worldwide. From basic science and pathophysiology to clinical best practices, Brenner & Rector’s The Kidney is your go-to resource for any stage of your career.

Key Features

  • Review of the basic science that underpins clinical nephrology, comprehensive selection of the most important bibliographical sources in nephrology, and Board Review-style questions help you prepare for certification or recertification.
  • Coverage of kidney health and disease from pre-conception through fetal and infant health, childhood, adulthood, and into old age. Expanded sections and chapter on global perspective and ethical considerations.
  • Uniform terminology and nomenclature in line with emerging consensus in world kidney community.
  • More than 700 full-color high-quality photographs as well as carefully chosen figures, algorithms, and tables to illustrate essential concepts, nuances of clinical presentation and technique, and decision making provide a visual grasp and better understanding of critical information.

Table of Contents

Section I: Normal Structure and Function

1 Embryology of the Kidney

2 Anatomy of the Kidney

3 The Renal Circulations and Glomerular Ultrafiltration

4 The Podocyte

5 Metabolic Basis of Solute Transport

6 Transport of Sodium, Chloride, and Potassium

7 The Regulation of Calcium, Magnesium, and Phosphate Excretion by the Kidney

8 Renal Handling of Organic Solutes

9 Renal Acidification Mechanisms

10 Urine Concentration and Dilution

11 The Cell Biology of Vasopressin Action

12 Aldosterone and Mineralocorticoid Receptors: Renal and Extrarenal Roles

13 Vasoactive Molecules and the Kidney

14 Arachidonic Acid Metabolites and the Kidney

Section II: Disorders of Body Fluid Volume and Composition

15 Disorders of Sodium Balance

16 Disorders of Water Balance

17 Disorders of Acid-Base Balance

18 Disorders of Potassium Balance

19 Disorders of Calcium, Magnesium, and Phosphate Balance

Section III: Epidemiology and Risk Factors in Kidney Disease

20 Epidemiology of Kidney Disease

21 Demographics of Kidney Disease

22 Risk Factors and Chronic Kidney Disease

23 Nephron Endowment and Developmental Programming of Blood Pressure and Renal Function

24 Aging and Kidney Disease

Section IV: Evaluation of the Patient with Kidney Disease

25 Approach to the Patient with Kidney Disease

26 Laboratory Assessment of Kidney Disease: Glomerular Filtration Rate, Urinalysis, and Proteinuria

27 Interpretation of Electrolyte and Acid-Base Parameters in Blood and Urine

28 Diagnostic Kidney Imaging

29 The Kidney Biopsy

30 Biomarkers in Acute and Chronic Kidney Diseases

Section V: Disorders of Kidney Structure and Function

31 Acute Kidney Injury

32 Primary Glomerular Disease

33 Secondary Glomerular Disease

34 Overview of Therapy for Glomerular Disease

35 Microvascular and Macrovascular Diseases of the Kidney

36 Tubulointerstitial Diseases

37 Urinary Tract Infection in Adults

38 Urinary Tract Obstruction

39 Diabetic Nephropathy

40 Urolithiasis

41 Kidney Cancer

42 Onco-Nephrology: Kidney Disease in Patients with Cancer 

Section VI: Genetics of Kidney Disease

43 Genetic Basis of Kidney Disease

44 Inherited Disorders of the Glomerulus

45 Inherited Disorders of the Renal Tubule

46 Cystic Diseases of the Kidney

Section VII: Hypertension and the Kidney

47 Primary and Secondary Hypertension

48 Renovascular Hypertension and Ischemic Nephropathy

49 Hypertension and Kidney Disease in Pregnancy

50 Antihypertensive Therapy

51 Diuretics

Section VIII: The Consequences of Advanced Kidney Disease

52 Adaptation to Nephron Loss and Mechanisms of Progression in Chronic Kidney Disease

53 Mechanisms and Consequences of Proteinuria

54 The Pathophysiology of Uremia

55 Chronic Kidney Disease-Mineral Bone Disorder

56 Cardiovascular Aspects of Kidney Disease

57 Hematologic Aspects of Kidney Disease

58 Endocrine Aspects of Chronic Kidney Disease

59 Neurologic Aspects of Kidney Disease

60 Dermatologic Conditions in Kidney Disease

Section IX: Conservative Management of Kidney Disease

61 Dietary Approaches to Kidney Diseases

62 A Stepped Care Approach to the Management of Chronic Kidney Disease

63 Therapeutic Approach to Chronic Kidney Disease-Mineral and Bone Disorder

64 Drug Dosing Considerations in Patients with Acute Kidney Injury and Chronic Kidney Disease

Section X: Dialysis and Extracorporeal Therapies

65 Hemodialysis

66 Peritoneal Dialysis

67 Critical Care Nephrology

68 Plasmapheresis

69 Elimination Enhancement of Poisons

70 Interventional Nephrology

Section XI: Kidney Transplantation

71 Transplantation Immunobiology

72 Clinical Management of the Adult Kidney Transplant Recipient

Section XII: Pediatric Nephrology

73 Malformation of the Kidney: Structural and Functional Consequences

74 Diseases of the Kidney and Urinary Tract in Children

75 Fluid, Electrolyte, and Acid-Base Disorders in Children

76 Renal Replacement Therapy (Dialysis and Transplantation) in Pediatric End-Stage Kidney Disease

Section XIII: Global Considerations in Kidney Disease

77 Latin America

78 Africa

79 Near and Middle East

80 Indian Subcontinent

81 The Far East

82 Oceania Region

Section XIV: Challenges in Nephrology

83 Ethical Dilemmas Facing Nephrology: Past, Present, and Future

84 Health Disparities in Nephrology

85 Care of the Older Person with Chronic Kidney Disease

86 Tissue Engineering, Stem Cells, and Cell Therapy in Nephrology

87 Quality Improvement Initiatives in Kidney Disease


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About the Author

Karl Skorecki

Affiliations and Expertise

Annie Chutick Professor and Chair in Medicine (Nephrology), Technion-Israel Institute of Technology, Director of Medical and Research Development, Rambam Health Care Campus, Haifa, Israel

Glenn Chertow

Affiliations and Expertise

Norman S. Coplon/ Satellite Healthcare, Professor of Medicine, Chief, Division of Nephrology, Stanford University School of Medicine, Stanford, Palo Alto, California, USA

Philip Marsden

Affiliations and Expertise

Professor of Medicine, Elisabeth Hofmann Chair in Translational Research, Oreopoulos-Baxter Division Director of Nephrology; Vice Chair Research, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

Maarten Taal

Affiliations and Expertise

Professor of Medicine, Division of Medical Sciences and Graduate Entry Medicine, University of Nottingham; Honorary Consultant Nephrologist, Department of Renal Medicine, Royal Derby Hospital, Derby, United Kingdom

Alan Yu

Affiliations and Expertise

Harry Statland and Solon Summerfield Professor of Medicine, Director, Division of Nephrology and Hypertension and the Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas