Breathborne Biomarkers and the Human Volatilome

Breathborne Biomarkers and the Human Volatilome

2nd Edition - June 6, 2020

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  • Editors: Jonathan Beauchamp, Cristina Davis, Joachim Pleil
  • Paperback ISBN: 9780128199671
  • eBook ISBN: 9780128223970

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Breathborne biomarkers carry information on the state of human health, and their role in aiding clinical diagnosis or in therapeutic monitoring has become increasingly important as advances in the field are made. Breathborne Biomarkers and the Human Volatilome, Second Edition, provides a comprehensive update and reworking of the 2013 book Volatile Biomarkers, by Anton Amann and David Smith. The new editing team has expanded this edition beyond volatile organic compounds to cover the broad field of breath analysis, including the many exciting developments that have occurred since the first edition was published. This thoroughly revised volume includes the latest discoveries and applications in breath research from the world's foremost scientists, and offers insights into related future developments. It is an ideal resource for researchers, scientists, and clinicians with an interest in breath analysis.

Key Features

  • Presents recent advances in the field of breath analysis
  • Includes an extensive overview of established biomarkers, detection tools, disease targets, specific applications, data analytics, and study design
  • Offers a broad treatise of each topic, from basic concepts to a comprehensive review of discoveries, current consensus of understanding, and prospective future developments
  • Acts as both a primer for beginners and a reference for seasoned researchers


Chemists, biochemists, cell biologists, physiologists, and clinicians with an interest in breath analysis; developers and suppliers of analytical instrumentation suitable for breath analysis, researchers in metabolomics and volatolomics

Table of Contents

    • Foreword
    • Dedication
    • Preface

    PART A: Concepts and modeling
    1. Breath biomakers and the exposome
    2. Breath sampling and standardization
    3. Physiological modeling of exhaled compounds
    4. Exhaled nitric oxide physiology and modeling

    PART B: Inorganics and non-volatiles
    5. Exhaled nitric oxide in clinical practice
    6. Exhaled carbon monoxide
    7. Exhaled breath condensate and aerosol
    8. Exhaled particles

    PART C: Analytics
    9. Selected ion flow tube mass spectrometry
    10. Proton transfer reactionmass spectrometry
    11. Ion mobility spectrometry
    12. Secondary electrospray ionization
    13. Sensor systems
    14. Optical spectroscopy
    15. Comprehensive gas chromatography-mass spectrometry
    16. High-resolution mass spectrometry

    PART D: Breath tests
    17. 13C breath tests
    18. Breath monitoring in the intensive care unit
    19. Chronic obstructive pulmonary disease and smokers
    20. Clinical phenotyping
    21.  Breath analysis for respiratory infections
    22. Volatile biomarkers of malaria infection
    23. Lifestyle applications

    PART E: Beyond human breath
    24. Biomarkers in urine and stool
    25. Volatile emissions from skin
    26. Cell cultures as in vitro models for breath research
    27. Ruminants
    28. Breath analysis in marine mammals

    PART F: Field applications
    29.  Breath analysis in law enforcement
    30. Drugs in breath
    31. Urban search and rescue
    32. Breath analysis in occupational medicine
    33. Breath biomarkers in human xenobiotic exposure studies
    34. Canine olfaction

    PART G: Design and interpretation
    35. Clinical study design
    36. Challenges in clinical breath research development
    37. Mathematical interpretation of targeted volatilome data
    38. Preprocessing and analysis of volatilome data
    39. Applications of the US EPA CompTox Chemicals Dashboard to support mass spectrometry and breath research

Product details

  • No. of pages: 722
  • Language: English
  • Copyright: © Elsevier 2020
  • Published: June 6, 2020
  • Imprint: Elsevier
  • Paperback ISBN: 9780128199671
  • eBook ISBN: 9780128223970

About the Editors

Jonathan Beauchamp

Jonathan Beauchamp is manager of the Emissions Analytics and Diagnostics group at the Fraunhofer Institute for Process Engineering and Packaging IVV in Freising, Germany. He has been involved in academic and industrial breath research for the past 15 years and is currently principal investigator in several breath-related projects. He is an active member and current treasurer of the International Association of Breath Research (IABR).

Affiliations and Expertise

Manager, Emissions Analytics and Diagnostics group, Fraunhofer Institute for Process Engineering and Packaging IVV, Freising, Germany

Cristina Davis

Cristina Davis is chair and professor of Mechanical and Aerospace Engineering at the University of California Davis, United States. Her research focuses on development of novel chemical and biological sensor systems and biomarker identification in agriculture and human/animal health monitoring. She has 12 issued patents and has coauthored over 100 peer-reviewed journal articles and book chapters. She is current chair-elect of IABR.

Affiliations and Expertise

Chair and professor, Department of Mechanical and Aerospace Engineering, University of California, Davis, CA, United States

Joachim Pleil

Joachim Pleil is adjunct professor at the University of North Carolina, School of Public Health, United States. He has published over 150 journal articles, many involving breath biomarker research and statistical interpretation of breath-based data. He has retired from US Environmental Protection Agency after 32 years as a research scientist. He is currently a consultant for NASA on a pilot breathing assessment project and is a founding member of IABR.

Affiliations and Expertise

Adjunct professor, Department of Environmental Sciences and Engineering, Gillings School of Public Health, University of North Carolina, Chapel Hill, NC, United States

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