Breathborne Biomarkers and the Human Volatilome - 2nd Edition - ISBN: 9780128199671

Breathborne Biomarkers and the Human Volatilome

2nd Edition

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Editors: Jonathan Beauchamp Cristina Davis Joachim Pleil
Paperback ISBN: 9780128199671
Imprint: Elsevier
Published Date: 1st June 2020
Page Count: 670
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Breathborne biomarkers carry information on the state of human health, and their role in aiding clinical diagnosis or in therapeutic monitoring has become increasingly important as advances in the field are made. Breathborne Biomarkers and the Human Volatilome, Second Edition, provides a comprehensive update and reworking of the 2013 book Volatile Biomarkers, by Anton Amann and David Smith. The new editing team has expanded this edition beyond volatile organic compounds to cover the broad field of breath analysis, including the many exciting developments that have occurred since the first edition was published. This thoroughly revised volume includes the latest discoveries and applications in breath research from the world's foremost scientists, and offers insights into related future developments. It is an ideal resource for researchers, scientists, and clinicians with an interest in breath analysis.

Key Features

  • Presents recent advances in the field of breath analysis
  • Includes an extensive overview of established biomarkers, detection tools, disease targets, specific applications, data analytics, and study design
  • Offers a broad treatise of each topic, from basic concepts to a comprehensive review of discoveries, current consensus of understanding, and prospective future developments
  • Acts as both a primer for beginners and a reference for seasoned researchers



Chemists, biochemists, cell biologists, physiologists, and clinicians with an interest in breath analysis

Table of Contents


Dedication to Anton Amann


PART A: Concepts and Modeling

1. Breath Biomakers and the Exposome

2. Sampling and Standardization

3. Physiological Modeling of Exhaled Breath

4. Nitric Oxide: Physiology and Modeling

PART B: Inorganics and Non-Volatiles

5. Nitric Oxide: Clinical Applicaitons

6. Carbon Monoxide in Pulmonary Diseases

7. Exhaled Breath Condensate and Aerosols

8. Particles in Exhaled Breath

PART C: Analytics

9. Selected Ion Flow Tube Mass Spectrometry

10. Proton Transfer Reaction Mass Spectrometry

11. Ion Mobility Spectrometry

12. Secondary Electrospray Ionization

13. Sensor Systems

14. Optical Spectroscopy

15. Comprehensive Gas Chromatography-Mass Spectrometry

16. High-Resolution Mass Spectrometry

PART D: Breath Tests

17. Isotope Labelled Substrates

18. Breath Analysis in Critically Ill Patients

19. Chronic Obstructive Pulmonary Disease and Smokers

20. Clinical Phenotyping

21. Respiratory Infections

22. Volatile Biomarkers of Malaria Infection

23. Lifestyle Applications

PART E: Beyond Human Breath

24. Biomarkers in Urine and Stool

25. Skin Emanations

26. Cell Cultures As In Vitro Models For Breath Research

27. Ruminants

28. Marine Mammals

PART F: Field Applications

29. Breath Analysis in Law Enforcement

30. Drugs in Breath

31. Urban Search and Rescue

32. Occupational Medicine

33. Human Exposure Studies

34. Canine olfaction

PART G: Design and Interpretation

35. Clinical Study Design

36. Challenges in Clinical Breath Research Development

37. Mathematical and Statistical Approaches

38. Data Analysis, Signal Processing and Classification

39. Applications of the US EPA CompTox Chemicals Dashboard to support mass spectrometry and breath research



No. of pages:
© Elsevier 2020
1st June 2020
Paperback ISBN:

About the Editor

Jonathan Beauchamp

Jonathan Beauchamp is manager of the Emissions Analytics and Diagnostics group at the Fraunhofer Institute for Process Engineering and Packaging IVV in Freising, Germany. He has been involved in academic and industrial breath research for the past 15 years and is currently principal investigator in several breath-related projects. He is an associate editor of Journal of Breath Research and an active member and current treasurer of the International Association of Breath Research (IABR).

Affiliations and Expertise

Manager, Emissions Analytics and Diagnostics group, Fraunhofer Institute for Process Engineering and Packaging IVV, Freising, Germany

Cristina Davis

Cristina Davis is chair and professor of Mechanical and Aerospace Engineering at the University of California Davis, United States. Her research focuses on development of novel chemical and biological sensor systems, and biomarker identification in agriculture and human/animal health monitoring. She has 12 issued patents and has coauthored over 100 peer-reviewed journal articles and book chapters. She is current chair-elect of IABR.

Affiliations and Expertise

Chair and professor of Mechanical and Aerospace Engineering, University of California Davis, United States

Joachim Pleil

Joachim Pleil is adjunct professor at the University of North Carolina, School of Public Health, United States. He has published over 150 journal articles, many involving breath biomarker research and statistical interpretation of breath-based data. He has retired from US Environmental Protection Agency after 32 years as a research scientist. He currently serves as editor-in-chief of Journal of Breath Research, is a consultant for NASA on a pilot breathing assessment project, and is a founding member of IABR.

Affiliations and Expertise

Adjunct professor, University of North Carolina, School of Public Health, United States

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