Breathborne Biomarkers and the Human Volatilome
2nd Edition
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Description
Breathborne biomarkers carry information on the state of human health, and their role in aiding clinical diagnosis or in therapeutic monitoring has become increasingly important as advances in the field are made. Breathborne Biomarkers and the Human Volatilome, Second Edition, provides a comprehensive update and reworking of the 2013 book Volatile Biomarkers, by Anton Amann and David Smith. The new editing team has expanded this edition beyond volatile organic compounds to cover the broad field of breath analysis, including the many exciting developments that have occurred since the first edition was published. This thoroughly revised volume includes the latest discoveries and applications in breath research from the world's foremost scientists, and offers insights into related future developments. It is an ideal resource for researchers, scientists, and clinicians with an interest in breath analysis.
Key Features
- Presents recent advances in the field of breath analysis
- Includes an extensive overview of established biomarkers, detection tools, disease targets, specific applications, data analytics, and study design
- Offers a broad treatise of each topic, from basic concepts to a comprehensive review of discoveries, current consensus of understanding, and prospective future developments
- Acts as both a primer for beginners and a reference for seasoned researchers
Readership
Chemists, biochemists, cell biologists, physiologists, and clinicians with an interest in breath analysis
Table of Contents
Foreword
Dedication to Anton Amann
Preface
PART A: Concepts and Modeling
1. Breath Biomakers and the Exposome
2. Sampling and Standardization
3. Physiological Modeling of Exhaled Breath
4. Nitric Oxide: Physiology and Modeling
PART B: Inorganics and Non-Volatiles
5. Nitric Oxide: Clinical Applicaitons
6. Carbon Monoxide in Pulmonary Diseases
7. Exhaled Breath Condensate and Aerosols
8. Particles in Exhaled Breath
PART C: Analytics
9. Selected Ion Flow Tube Mass Spectrometry
10. Proton Transfer Reaction Mass Spectrometry
11. Ion Mobility Spectrometry
12. Secondary Electrospray Ionization
13. Sensor Systems
14. Optical Spectroscopy
15. Comprehensive Gas Chromatography-Mass Spectrometry
16. High-Resolution Mass Spectrometry
PART D: Breath Tests
17. Isotope Labelled Substrates
18. Breath Analysis in Critically Ill Patients
19. Chronic Obstructive Pulmonary Disease and Smokers
20. Clinical Phenotyping
21. Respiratory Infections
22. Volatile Biomarkers of Malaria Infection
23. Lifestyle Applications
PART E: Beyond Human Breath
24. Biomarkers in Urine and Stool
25. Skin Emanations
26. Cell Cultures As In Vitro Models For Breath Research
27. Ruminants
28. Marine Mammals
PART F: Field Applications
29. Breath Analysis in Law Enforcement
30. Drugs in Breath
31. Urban Search and Rescue
32. Occupational Medicine
33. Human Exposure Studies
34. Canine olfaction
PART G: Design and Interpretation
35. Clinical Study Design
36. Challenges in Clinical Breath Research Development
37. Mathematical and Statistical Approaches
38. Data Analysis, Signal Processing and Classification
39. Applications of the US EPA CompTox Chemicals Dashboard to support mass spectrometry and breath research
Details
- No. of pages:
- 670
- Language:
- English
- Copyright:
- © Elsevier 2020
- Published:
- 1st June 2020
- Imprint:
- Elsevier
- Paperback ISBN:
- 9780128199671
About the Editor
Jonathan Beauchamp
Jonathan Beauchamp is manager of the Emissions Analytics and Diagnostics group at the Fraunhofer Institute for Process Engineering and Packaging IVV in Freising, Germany. He has been involved in academic and industrial breath research for the past 15 years and is currently principal investigator in several breath-related projects. He is an associate editor of Journal of Breath Research and an active member and current treasurer of the International Association of Breath Research (IABR).
Affiliations and Expertise
Manager, Emissions Analytics and Diagnostics group, Fraunhofer Institute for Process Engineering and Packaging IVV, Freising, Germany
Cristina Davis
Cristina Davis is chair and professor of Mechanical and Aerospace Engineering at the University of California Davis, United States. Her research focuses on development of novel chemical and biological sensor systems, and biomarker identification in agriculture and human/animal health monitoring. She has 12 issued patents and has coauthored over 100 peer-reviewed journal articles and book chapters. She is current chair-elect of IABR.
Affiliations and Expertise
Chair and professor of Mechanical and Aerospace Engineering, University of California Davis, United States
Joachim Pleil
Joachim Pleil is adjunct professor at the University of North Carolina, School of Public Health, United States. He has published over 150 journal articles, many involving breath biomarker research and statistical interpretation of breath-based data. He has retired from US Environmental Protection Agency after 32 years as a research scientist. He currently serves as editor-in-chief of Journal of Breath Research, is a consultant for NASA on a pilot breathing assessment project, and is a founding member of IABR.
Affiliations and Expertise
Adjunct professor, University of North Carolina, School of Public Health, United States