Breathborne Biomarkers and the Human Volatilome

Breathborne biomarkers carry information on the state of human health, and their role in aiding clinical diagnosis or in therapeutic monitoring has become increasingly important as advances in the field are made. Breathborne Biomarkers and the Human Volatilome, Second Edition, provides a comprehensive update and reworking of the 2013 book Volatile Biomarkers, by Anton Amann and David Smith. The new editing team has expanded this edition beyond volatile organic compounds to cover the broad field of breath analysis, including the many exciting developments that have occurred since the first edition was published. This thoroughly revised volume includes the latest discoveries and applications in breath research from the world's foremost scientists, and offers insights into related future developments. It is an ideal resource for researchers, scientists, and clinicians with an interest in breath analysis.

• Presents recent advances in the field of breath analysis
• Includes an extensive overview of established biomarkers, detection tools, disease targets, specific applications, data analytics, and study design
• Offers a broad treatise of each topic, from basic concepts to a comprehensive review of discoveries, current consensus of understanding, and prospective future developments
• Acts as both a primer for beginners and a reference for seasoned researchers

Chemists, biochemists, cell biologists, physiologists, and clinicians with an interest in breath analysis; developers and suppliers of analytical instrumentation suitable for breath analysis, researchers in metabolomics and volatolomics

• Foreword
• Dedication
• Preface

PART A: Concepts and modeling
1. Breath biomakers and the exposome
2. Breath sampling and standardization
3. Physiological modeling of exhaled compounds
4. Exhaled nitric oxide physiology and modeling

PART B: Inorganics and non-volatiles
5. Exhaled nitric oxide in clinical practice
6. Exhaled carbon monoxide
7. Exhaled breath condensate and aerosol
8. Exhaled particles

PART C: Analytics
9. Selected ion flow tube mass spectrometry
10. Proton transfer reaction—mass spectrometry
11. Ion mobility spectrometry
12. Secondary electrospray ionization
13. Sensor systems
14. Optical spectroscopy
15. Comprehensive gas chromatography-mass spectrometry
16. High-resolution mass spectrometry

PART D: Breath tests
17. 13C breath tests
18. Breath monitoring in the intensive care unit
19. Chronic obstructive pulmonary disease and smokers
20. Clinical phenotyping
21. Breath analysis for respiratory infections
22. Volatile biomarkers of malaria infection
23. Lifestyle applications

PART E: Beyond human breath
24. Biomarkers in urine and stool
25. Volatile emissions from skin
26. Cell cultures as in vitro models for breath research
27. Ruminants
28. Breath analysis in marine mammals

PART F: Field applications
29. Breath analysis in law enforcement
30. Drugs in breath
31. Urban search and rescue
32. Breath analysis in occupational medicine
33. Breath biomarkers in human xenobiotic exposure studies
34. Canine olfaction

PART G: Design and interpretation
35. Clinical study design
36. Challenges in clinical breath research development
37. Mathematical interpretation of targeted volatilome data
38. Preprocessing and analysis of volatilome data
39. Applications of the US EPA CompTox Chemicals Dashboard to support mass spectrometry and breath research