Brain Signal Transduction and Memory

Brain Signal Transduction and Memory

1st Edition - June 28, 1990

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  • Editor: Masao Ito
  • eBook ISBN: 9780323156585

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Description

Brain Signal Transduction and Memory is a compilation of the proceedings of the Fifth Takeda Science Foundation Symposium on Bioscience, held on November 28-30, 1988, in Kyoto, Japan. The symposium provided a forum for the discussion of a wide range of topics on brain signal transduction and its role in memory formation. Topics covered include the role of phosphoinositides in neural signaling; the homeostasis of calcium ions; the involvement of protein kinase C in brain signal transduction and memory formation; long-term potentiation in the hippocampus; synaptic plasticity and memory; and organization of neural tissues by plasticity. This book is comprised of 21 chapters and begins with an analysis of the phosphoinositide signaling system and how it might function within the nervous system, followed by a discussion on the molecular heterogeneity of the protein kinase C family and its implications for the regulation of neuronal cells. The formation and reorganization of synaptic contacts in the developing nervous system, as well as the factors that influence the plasticity of this process, are then explored. Other chapters focus on the biochemical mechanisms involved in the generation and maintenance of enhanced synaptic transmission; quantal release in the hippocampus; molecular mechanisms of long-term depression in the cerebellum; and cellular mechanisms for reorganization of synaptic inputs after early brain damage. This monograph will appeal to biologists, physiologists, bioscientists, and clinicians.

Table of Contents


  • Foreword

    Preface

    I. Overviews

    Phosphoinositides and Neural Signaling

    The Heterogeneity of Protein Kinase C and Its Implications for Neuronal Cell Regulation

    Molecular Mechanisms for Long-Term Memory in Aplysia

    II. Homeostasis of Calcium Ions

    Mechanisms Underlying the Generation and Control of [Ca2-]i Transients in Neurons and Neurosecretory Cells

    Heterogeneous Distribution and Temporal Changes of Cytoplasmic Free Calcium in Gastric Parietal Cells and Platelets

    The Role of Ca2+/Calmodulin-Dependent Protein Kinase II in Neuronal Functions

    III. Involvement of Protein Kinase C

    Cytochemical Evidence of Protein Kinase C in Neuronal Tissues

    The Protein Kinase C Substrate Protein B-50 in Neural Signal Transduction and Plasticity

    Modulation of Two K + Currents by Inositol Trisphosphate and Protein Kinase C

    The Role of Protein Kinase C and Phosphoinositide Metabolites in Neurons That Control Prolonged Reproductive Behaviors in Aplysia

    IV. Long-Term Potentiation in the Hippocampus

    Quantal Release in the Hippocampus

    Mechanisms Involved in the Initiation and Expression of Long-term Potentiation

    Cholinergic and Noradrenergic Modulation of Long-Term Potentiation in Hippocampal CA3 Neurons

    Presynaptic Mechanisms Underlying the Maintenance of Long-term Potentiation in the Hippocampus

    V. Synaptic Plasticity and Memory

    Molecular Mechanisms of Long-Term Depression in the Cerebellum

    Molecular Basis for the Hebb Synapse

    The Physical Reality of Memory

    Molecular Mechanisms Underlying Synaptic Plasticity in the Developing Visual Cortex

    VI. Organization of Neural Tissues by Plasticity

    Terminal Sprouting and Functional Plasticity at Neuromuscular Junctions

    Roles of Nerve Growth Factor in the Central Nervous System

    Cellular Mechanisms for Reorganization of Synaptic Inputs after Early Brain Damage

    Index

Product details

  • No. of pages: 310
  • Language: English
  • Copyright: © Academic Press 1990
  • Published: June 28, 1990
  • Imprint: Academic Press
  • eBook ISBN: 9780323156585

About the Editor

Masao Ito

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