Brain Signal Transduction and Memory - 1st Edition - ISBN: 9780123756558, 9780323156585

Brain Signal Transduction and Memory

1st Edition

Editors: Masao Ito
eBook ISBN: 9780323156585
Imprint: Academic Press
Published Date: 28th June 1990
Page Count: 310
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Brain Signal Transduction and Memory is a compilation of the proceedings of the Fifth Takeda Science Foundation Symposium on Bioscience, held on November 28-30, 1988, in Kyoto, Japan. The symposium provided a forum for the discussion of a wide range of topics on brain signal transduction and its role in memory formation. Topics covered include the role of phosphoinositides in neural signaling; the homeostasis of calcium ions; the involvement of protein kinase C in brain signal transduction and memory formation; long-term potentiation in the hippocampus; synaptic plasticity and memory; and organization of neural tissues by plasticity. This book is comprised of 21 chapters and begins with an analysis of the phosphoinositide signaling system and how it might function within the nervous system, followed by a discussion on the molecular heterogeneity of the protein kinase C family and its implications for the regulation of neuronal cells. The formation and reorganization of synaptic contacts in the developing nervous system, as well as the factors that influence the plasticity of this process, are then explored. Other chapters focus on the biochemical mechanisms involved in the generation and maintenance of enhanced synaptic transmission; quantal release in the hippocampus; molecular mechanisms of long-term depression in the cerebellum; and cellular mechanisms for reorganization of synaptic inputs after early brain damage. This monograph will appeal to biologists, physiologists, bioscientists, and clinicians.

Table of Contents



I. Overviews

Phosphoinositides and Neural Signaling

The Heterogeneity of Protein Kinase C and Its Implications for Neuronal Cell Regulation

Molecular Mechanisms for Long-Term Memory in Aplysia

II. Homeostasis of Calcium Ions

Mechanisms Underlying the Generation and Control of [Ca2-]i Transients in Neurons and Neurosecretory Cells

Heterogeneous Distribution and Temporal Changes of Cytoplasmic Free Calcium in Gastric Parietal Cells and Platelets

The Role of Ca2+/Calmodulin-Dependent Protein Kinase II in Neuronal Functions

III. Involvement of Protein Kinase C

Cytochemical Evidence of Protein Kinase C in Neuronal Tissues

The Protein Kinase C Substrate Protein B-50 in Neural Signal Transduction and Plasticity

Modulation of Two K + Currents by Inositol Trisphosphate and Protein Kinase C

The Role of Protein Kinase C and Phosphoinositide Metabolites in Neurons That Control Prolonged Reproductive Behaviors in Aplysia

IV. Long-Term Potentiation in the Hippocampus

Quantal Release in the Hippocampus

Mechanisms Involved in the Initiation and Expression of Long-term Potentiation

Cholinergic and Noradrenergic Modulation of Long-Term Potentiation in Hippocampal CA3 Neurons

Presynaptic Mechanisms Underlying the Maintenance of Long-term Potentiation in the Hippocampus

V. Synaptic Plasticity and Memory

Molecular Mechanisms of Long-Term Depression in the Cerebellum

Molecular Basis for the Hebb Synapse

The Physical Reality of Memory

Molecular Mechanisms Underlying Synaptic Plasticity in the Developing Visual Cortex

VI. Organization of Neural Tissues by Plasticity

Terminal Sprouting and Functional Plasticity at Neuromuscular Junctions

Roles of Nerve Growth Factor in the Central Nervous System

Cellular Mechanisms for Reorganization of Synaptic Inputs after Early Brain Damage



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© Academic Press 1989
Academic Press
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About the Editor

Masao Ito

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