
Brain Receptor Methodologies Pt A
General Methods and Concepts. Amines and Acetylcholine
Description
Table of Contents
Contributors
General Preface
Preface to Part A
Contents of Part B
Section I General Methods and Concepts Relating to Receptor Studies
A. Some Introductory Considerations Relevant to Receptor Studies
1. Receptors: A Historical Perspective
2 . Preparation of Labeled Receptor Ligands
3 . Heterogeneous Receptors and Binding Curve Analysis in Neurobiology
4. The Distribution of Peripheral Regulatory Peptides: A Dual Immunochemical (Immunocytochemistry and Radioimmunoassay) Approach
B. Methods for Studying the Receptor Molecule
5. The Solubilization of Membrane Proteins
6. Solubilization and Characterization of Brain Benzodiazepine Binding Sites
7. Solubilization of the Dopamine Receptor
8. Autoradiographic Demonstration of Receptor Distributions
9. Affinity and Photoaffinity Labeling of Receptors
C. Methods for Studying Receptor-Linked Effector Mechanisms
10. Cyclic Nucleotide and Adenylate Cyclase in Brain: Electrophysiological Studies
11. Calmodulin in the Nervous System
12. Preparation of the Catalytic Subunit of cAMP-Dependent Protein Kinase
13. Phospholipid Methylation in Brain and Other Tissues
Section II Specific Receptor-Binding Methodologies
A. Amines and Acetylcholines
14. ß-Adrenergic Receptors
15. α-Adrenergic Receptors in Neural Tissues: Methods and Applications of Radioligand Binding Assays
16. Dopamine Receptors in Brain
17. Radioactive Ligand Binding Studies: Identification of Central Serotonin Receptors
18. Muscarinic Receptor [3H]Ligand Binding Methods
Index
Product details
- No. of pages: 384
- Language: English
- Copyright: © Academic Press 1984
- Published: January 28, 1984
- Imprint: Academic Press
- eBook ISBN: 9780323152808
About the Editor
Paul J. Marangos
Dr. Marangos is author of 252 peer-reviewed research papers on neurobiology, and 4 books – three by Academic Press (the Neurobiological Research series of volumes) and a fourth titled “Emerging Strategies in Neuroprotection”. He is a founding editor of “The Journal of Molecular Neuroscience” and inventor on 14 issued patents. He spent 13 years at the NIMH and was adjunct professor of neurochemistry at GW School of Medicine during that time. He is co-Founder of five Biotech firms with over 20 years of experience as CEO of both public and private life science companies. He has had extensive experience in all aspects of the pharmaceutical and biotechnology industries from bench to product. This coupled with his academic experience has provided a global perspective on the entire medical R&D enterprise, in particular its faults, and remedies to speed the quest for cures.
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http://thehill.com/opinion/healthcare/383484-right-to-try-efforts-have-have-been-timid-and-poorly-conceived
https://www.prnewswire.com/news-releases/biomedica-partners-presents-major-reforms-in-terminal-disease-drug-development-at-magis-clinical-research-conference-300642731.html
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