Contributors. Preface. Acknowledgements. Mechanisms of Brain Plasticity: From Normal Brain Function to Pathology, P.A. Schwartzkroin. Brain Development and Generation of Brain Pathologies, G.L. Holmes and B. McCabe. Maturation of Channels and Receptors: Consequences for Excitability, D.F. Owens and A.R. Kriegstein. Neuronal Activity and the Establishment of Normal and Epileptic Circuits during Brain Development, J.W. Swann, K.L. Smith, and C.L. Lee. The Effects of Seizures on the Hippocampus of the Immature Brain, E.F. Sperber and S.L. Moshé. Abnormal Development and Catastrophic Epilepsies: the Clinical Picture and Relation to Neuroimaging, H.T. Chugani and D.C. Chugani. Cortical Reorganization and Seizure Generation in Dysplastic Cortex, G. Avanzini, R. Spreafico, S. Franceschetti, G. Sancini, G. Battaglia, and V. Sciaoli. Rasmussen's Syndrome with Particular Reference to Cerebral Plasticity: A Tribute to Frank Morrell, F. Andermann and Y. Hart. Structural Reorganization of Hippocampal Networks Caused by Seizure Activity, D.H. Lowenstein. Epilepsy-Associated Plasticity in g-Aminobutyric Acid Receptor Expression, Function, and Inhibitory Synaptic Properties, D.A. Coulter. Synaptic Plasticity and Secondary Epileptogenesis, T.J. Teyler, S.L. Morgan, R.N. Russell, and B.L. Woodside. Synaptic Plasticity in Epileptogenesis: Cellular Mechanisms Underlying Long-Lasting Synaptic Modifications That Require New Gene Expression, O. Steward, C.S. Wallace, and P.F. Worley. Cellular Correlates of Behavior, E.R. Wood, P.A. Dudchenko, and H. Eichenbaum. Mechanisms of Neuronal Conditioning, D.A.T. King, D.J. Krupa, M.R. Foy, and R.F. Thompson. Plasticity in the Aging Central Nervous System, C.A. Barnes. Secondary Epileptogenesis, Kindling, and Intractable Epilepsy: A Reappraisal from the Perspective of Neural Plasticity, T.P. Sutula. Kindling and the Mirror Focus, D.C. McIntyre and M.O. Poulter. Partial Kindling and Behavioral Pathologies, R.E. Adamec. The Mirror Focus and Secondary Epileptogenesis, B.J. Wilder. Hippocampal Lesions in Epilepsy: A Historical Review, R. Naquet. Clinical Evidence for Secondary Epileptogenesis, H.O. Lüders. Epilepsy as a Progressive (or Nonprogressive "Benign") Disorder, J.A. Wada. Pathophysiological Aspects of Landau-Kleffner Syndrome: From the Active Epileptic Phase to Recovery, M.-N. Metz-Lutz, P. Maquet, A. De Saint Martin, G. Rudolf, N. Wioland, E. Hirsch, and C. Marescaux. Local Pathways of Seizure Propagation in Neocortex, B.W. Connors, D.J. Pinto, and A.E. Telfeian. Multiple Subpial Transection: A Clinical Assessment, C.E. Polkey. The Legacy of Frank Morrell, J. Engel, Jr. Index.
This volume of International Review of Neurobiology integrates the latest developments in normal and abnormal neuroplasticity and epilepsy, and considers their implications for understanding the basic mechanisms of normal and pathological behaviors. The chapters are written by leaders in the field, and provide comprehensive coverage of the subject, from molecular neurobiology to behavior. This book will help neuroscientists gain a better understanding of the application of fundamental neuronal mechanisms of plastic change to problems relevant to the diagnosis, treatment, and prevention of human disease, particularly epilepsy.
Individuals working in all disciplines of neuroscience, from undergraduate students to experienced investigators, as well as practitioners in the areas of neurology, neurosurgery, and psychiatry
- No. of pages:
- © Academic Press 2001
- 28th November 2000
- Academic Press
- eBook ISBN:
UCLA School of Medicine, Los Angeles, California, U.S.A.
University of California, Davis, USA
Dr. Moshé is a professor of neurology, neuroscience, and pediatrics at Albert Einstein College of Medicine. He is the Director of Child Neurology and Clinical Neurophysiology and the recipient of a Martin A. and Emily L. Fisher fellowship in Neurology and Pediatrics at Albert Einstein. Dr. Moshé received his M.D. from the National University of Athens School of Medicine, Athens, Greece in 1972. He trained in pediatrics at the University of Maryland and in neurology at Albert Einstein. Since 1979, his research has focused on understanding the mechanisms underlying age-related differences in epilepsy in humans and in animal models. During the last ten years, his interest has turned to elucidating the subcortical circuitry involved in the control of seizures as a function of age and the consequences of seizures on the developing brain.
Albert Einstein College of Medicine, Bronx, NY, USA
Harvard Medical School, Boston, Massachusetts, U.S.A.
Louisiana State University Medical Center, School of Medicine, Baton Rouge, U.S.A.
University of Texas, Austin, U.S.A.
King's College, London, U.K. Head of Pharmacology and Therapeutics Division