Brain Metastases from Primary Tumors, Volume 2 - 1st Edition - ISBN: 9780128014196, 9780128016893

Brain Metastases from Primary Tumors, Volume 2

1st Edition

Epidemiology, Biology, and Therapy

Editors: M. Hayat
eBook ISBN: 9780128016893
Hardcover ISBN: 9780128014196
Imprint: Academic Press
Published Date: 1st January 2015
Page Count: 236
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Description

Brain metastases are the most common malignant tumors of the central nervous system, yet their incidence appears to be increasing in spite of the advancement of cancer therapies. While much is known about primary cancers (including primary brain tumors), less work has been done to uncover the roots of metastatic disease. Brain Metastases from Primary Tumors fills that gap, serving as the first two-part reference to focus primarily on the link between primary cancers and brain metastases. This link is explored for the most common cancer types – lung, breast, and melanoma. Additionally, biological background as well as therapy for CNS metastases is addressed. Age- and gender-related trends are also discussed, as is the use of biomarkers for early detection.

Key Features

  • The only comprehensive reference detailing the link between primary cancers and brain metastases
  • Aids the target audience in determining the incidence of brain metastases in patients with a primary cancer
  • Provides education about the potential use of biomarkers for early detection, diagnosis and prevention of the spread of primary cancer to the brain
  • Documents temporal and gender-related trends in brain metastases from other cancers
  • Edited work with chapters authored by leaders in the field around the globe – the broadest, most expert coverage available
  • The only comprehensive reference detailing the link between primary cancers and brain metastases

Readership

Academic/clinical professors, post-doctoral fellows, and graduate and medical students in neuro-oncology, oncology, cancer research, pathology, and reproductive oncology

Table of Contents

  • Preface
  • Contributors
  • Volume 1– Contributions
  • I: General applications
    • Chapter 1: Brain Metastasis from Solid Tumors
      • Abstract
      • Introduction
      • Pathophysiology
      • Clinical presentation
      • Diagnosis
      • Prognostic factors
      • Treatment options
      • Future prospects and research approaches
    • Chapter 2: The Role of Surgical Resection for Metastatic Brain Tumors
      • Abstract
      • Introduction
      • Surgical resection
      • Clinical evidence
      • Tumor characteristics
      • Patient selection for surgery
      • Making surgery safe
      • Conclusion
    • Chapter 3: Whole-Brain Radiotherapy for Brain Metastases: Is the Therapeutic Window Enlarging?
      • Abstract
      • Introduction
      • Toxicity
      • Preventing and treating toxicity
      • Summary
  • II: Non-Small cell lung cancer
    • Chapter 4: Brain Metastasis in Patients with Non-Small Cell Lung Cancer: Response to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors
      • Abstract
      • Introduction
      • EGFR mutation in NSCLC
      • EGFR-TKI efficacy in NSCLC with CNS metastases
      • Conclusion
    • Chapter 5: Brain Metastasis from Non-Small Cell Lung Cancer: Use of Epidermal Growth Factor Receptor and HER2 Status for Targeted Therapy
      • Abstract
      • Introduction
      • Targeted therapy of NSCLC
      • EGFR deregulation
      • HER2 deregulation
      • Brain metastases in NSCLC
      • The question of the possibility of discordance in EGFR and HER2 status between primary tumor and metastases
      • Future perspective
    • Chapter 6: Brain Metastases from Non-Small Cell Lung Cancer: Current Evidence in Management Using Tyrosine Kinase Inhibitor and Whole-Brain Radiation Therapy
      • Abstract
      • Introduction
      • Brain metastases in EGFR-mutated NSCLC
      • TKI monotherapy in brain metastases NSCLC
      • Concurrent use of TKI and WBRT in brain metastases from NSCLC
      • Toxicities of combination of TKI and WBRT
      • Discussion
    • Chapter 7: Brain Metastasis in Patients with Non-Small Cell Lung Cancer: Immunohistochemical Markers
      • Abstract
      • Introduction
      • Markers with potential role in predicting NSCLC metastases to the brain Ki-67
      • Caspase-3
      • VEGF and VEGFR
      • E-cadherin/β-catenin complex
      • Epidermal growth factor receptor
      • Discussion
  • III: Breast cancer
    • Chapter 8: Brain Metastasis from Breast Cancer: Molecular Mechanisms
      • Abstract
      • Introduction
      • The “seed and soil” hypothesis
      • Molecular breast cancer subtypes and the patterns of metastatic dissemination
      • The blood–brain barrier is protective against BM and yet a challenge for BM therapeutics
      • Genes implicated in BM development
      • Future directions: What should we expect from “omics” studies on brain metastases?
      • Conclusions
    • Chapter 9: New Targeted Therapies for Brain Metastases from Breast and Lung Cancer and Melanoma
      • Abstract
      • Introduction
      • Targeted therapies for BM from breast cancer
      • Targeted therapies for BM from lung cancer
      • Targeted therapies for BM from melanoma patients
    • Chapter 10: Breast Cancers with Brain Metastases
      • Abstract
      • Introduction
      • Histopathology, grading, and molecular classification
      • Breast cancers with brain metastases
      • Molecular mechanisms
      • Treatment and prognosis
  • IV: Melanoma
    • Chapter 11: Brain Metastases in Melanoma Patients: Treatment with Adjuvant Postoperative Whole-Brain Radiotherapy
      • Abstract
      • Introduction
      • Therapies for melanoma BMs
      • Whole-brain radiotherapy
      • Current controversies in adjuvant WBRT
      • Future development and conclusion
      • Acknowledgments
    • Chapter 12: Melanoma Progression in the Brain: Role of Pericytes, the Basal Lamina, and Endothelial Cells in Tumor Vascularization
      • Abstract
      • Introduction
      • Role of pericytes in melanoma vascularization in the brain
      • Role of the basal lamina in melanoma vascularization in the brain
      • Role of endothelial cells in melanoma vascularization in the brain
      • Discussion
      • Acknowledgments
  • V: Esophageal cancer
    • Chapter 13: Brain Metastases from Esophageal Cancer in the Presence of HER-2 Overexpression
      • Abstract
      • Introduction
      • Brain metastases in esophageal cancer
      • HER-2 overexpression
      • Discussion
  • VI: Renal carcinoma
    • Chapter 14: Brain Metastasis from Renal Carcinoma: Locoregional and Systemic Treatments
      • Abstract
      • Introduction
      • Locoregional approach
      • Systemic approach: targeted therapies
      • Discussion
  • VII: Gastrointestinal cancer
    • Chapter 15: Gastrointestinal Cancer and Brain Metastasis Outcomes and Management
      • Abstract
      • Introduction
      • Esophageal cancer
      • Gastric cancer
      • Gallbladder cancer
      • Pancreatic cancer
      • Small bowel cancer
      • Colorectal cancer
      • Discussion
  • VIII: Colorectal cancer
    • Chapter 16: Brain Metastasis of Colorectal Cancer: Microenvironment and Molecular Mechanism
      • Abstract
      • Introduction
      • Molecules associated with metastatic potential
      • Role of BBB in brain metastasis
      • Brain microenvironment and tumor metastasis
      • Site-specific metastatic factors
      • Models for metastatic brain tumors
      • Conclusion
      • Acknowledgments
  • IX: Nasopharyngeal carcinoma
    • Chapter 17: Brain Metastasis from Nasopharyngeal Carcinoma
      • Abstract
      • Introduction
      • Brain metastasis from NPC
      • Summary
  • Index

Details

No. of pages:
236
Language:
English
Copyright:
© Academic Press 2015
Published:
Imprint:
Academic Press
eBook ISBN:
9780128016893
Hardcover ISBN:
9780128014196

About the Editor

M. Hayat

M. Hayat

Dr. Hayat has published extensively in the fields of microscopy, cytology, immunohistochemistry, immunocytochemistry, and antigen retrieval methods. He is Distinguished Professor, Department of Biological Sciences, Kean University, Union, New Jersey, USA.

Affiliations and Expertise

Distinguished Professor, Department of Biological Sciences, Kean University, Union, NJ, USA