Brain Mechanisms in Mental Retardation

Brain Mechanisms in Mental Retardation

1st Edition - January 1, 1975

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  • Editors: Nathaniel A. Buchwald, Mary A. B. Brazier
  • eBook ISBN: 9781483281810

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Description

Series on Mental Retardation held in Oxnard, California, in January 1974. This book compiles research on neurobiological findings which might lead to an understanding of the basic processes underlying the phenomena of mental deficiency and related aspects of human development. The topics discussed include the timing of major ontogenetic events in the visual cortex of the rhesus monkey; neuronal sprouting after hippocampal lesions; synaptic and dendritic development and mental defect; and CNS maturation and behavioral development. The neuronal control of neurochemical processes in the basal ganglia; nigrostriatal projections and the “dopamine receptor”; and effects of caudate nuclei removal in cats are also deliberated. This text likewise covers the effects of caudate nuclei removal versus frontal cortex lesions in kittens and role of biochemistry in research on mental retardation This publication is beneficial to medical practitioners and students concerned with mental retardation.

Table of Contents


  • List of Contributors and Participants

    Foreword

    Welcoming Remarks

    Part I Development of Neuronal Functions

    1 Timing of Major Ontogenetic Events in the Visual Cortex of the Rhesus Monkey

    References

    2 Effects of Interference with Cerebellar Maturation on the Development of Locomotion. An Experimental Model of Neurobehavioral Retardation

    References

    3 Neuronal Sprouting after Hippocampal Lesions

    References

    4 Physiological Properties of Vertebrate Nerve Cells in Tissue Culture

    References

    4A Discussion: Biochemical Studies in Various Culture Systems of Neural Tissues

    References

    5 Synaptic and Dendritic Development and Mental Defect

    References

    6 Normal and Aberrant Neuronal Development in the Cerebral Cortex of Human Fetus and Young Infant

    References

    6A Discussion: CNS Maturation and Behavioral Development

    References

    6B Discussion: Development of Postsynaptic Potentials Recorded from Immature Neurons in Kitten Visual Cortex

    References

    Part II Role of the Basal Ganglia in Normal and Abnormal Development

    7 Neurophysiological and Anatomical Interrelationships of the Basal Ganglia

    References

    8 Neuronal Control of Neurochemical Processes in the Basal Ganglia

    References

    8A Discussion: L-Dopa-Induced Improvement of Conditioned Response Inhibition

    References

    8B Discussion: Acetylcholine and the Caudate

    References

    9 Dopamine-Containing Neurons of the Substantia Nigra and Their Terminals in the Neostriatum

    References

    9A Discussion: Nigrostriatal Projections and the "Dopamine Receptor"

    References

    10 Effects of Caudate Nuclei Removal in Cats. Comparison with Effects of Frontal Cortex Ablation

    References

    Part III Behavioral Plasticity during Development

    11 Brainstem Substrates of Sensory Information Processing and Adaptive Behavior

    References

    11A Discussion: Neurophysiological Substrates of Behavioral Habituation and Conditioning

    References

    12 Unit Recordings during Pavlovian Conditioning

    References

    12A Discussion: "Operant Sensitization" and Some Remarks on Unit Recording in Conscious Animals

    References

    13 Age, Sex, and Experience as Related to the Neural Basis of Cognitive Development

    References

    13A Discussion: Effects of Caudate Nuclei Removal versus Frontal Cortex Lesions in Kittens

    References

    14 Prenatal Nutrition and Neurological Development

    References

    15 The Futility of Comparative IQ Research

    References

    Part IV Metabolic Defects in Development

    16 Hepatic Phenylalanine Hydroxylase and PKU

    References

    16A Discussion: Phenylalanine Hydroxylase in Human Kidney; Relevance to Phenylketonuria

    References

    17 Studies on the Molecular Defect in Galactosemia

    References

    18 The Enzymology of Tay-Sachs Disease and Its Variant Forms

    References

    18A Discussion: Metachromatic Leukodystrophy, an Unusual Case with a Subtle Cerebroside Sulfatase Defect

    References

    19 Role of Biochemistry in Research on Mental Retardation

    References

    Epilogue

    References

    Author Index

    Subject Index

Product details

  • No. of pages: 558
  • Language: English
  • Copyright: © Academic Press 1975
  • Published: January 1, 1975
  • Imprint: Academic Press
  • eBook ISBN: 9781483281810

About the Editors

Nathaniel A. Buchwald

Mary A. B. Brazier

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