Brain Machine Interfaces

Brain Machine Interfaces

Implications for Science, Clinical Practice and Society

1st Edition - August 21, 2011
This is the Latest Edition
  • Editors: Jens Schouenborg, Martin Garwicz, Nils Danielsen
  • eBook ISBN: 9780444538161
  • Hardcover ISBN: 9780444538154

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Description

This volume follows on from the symposium "Brain Machine Interfaces - Implications for science, clinical practice and society", held on August 26th-29th 2010 in Ystad, Sweden, and features contributions from pioneers and leading scientists in the field of BMI and motor systems physiology, including spinal cord, basal ganglia and motor cortex. The wide range of topics covered include implants for mind control of prostheses and in robotics, clinical and experimental research on Deep Brain Stimulation (DBS) for the treatment of Parkinson’s disease, depression and Alzheimer’s disease, cochlear implants, retinal implants, novel flexible micro- and nano-electrode implants, safety aspects including acute and chronic tissue reactions to implants and on ethical issues in DBS. Program and abstracts from the individual contributors can be found on http://www.med.lu.se/nrc/bmi_symposium.

Key Features

  • Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future research
  • Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered
  • All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Readership

Neuroscientists, psychologists, neurologists

Table of Contents

  • Series Editors

    List of Contributors

    Preface

    Chapter 1: Making the lifetime connection between brain and machine for restoring and enhancing function

    Introduction

    Methods

    Results

    Discussion

    Chapter 2: Out of the frying pan into the fire—the P300-based BCI faces real-world challenges

    Introduction

    P300

    Classification

    BCI applications

    Influences on BCI performance

    Nonvisual P300-based BCI systems

    BCI faces the real-world challenge: user experiences with state-of-the-art technology

    Conclusion

    Chapter 3: Toward a whole-body neuroprosthetic

    Introduction

    Whole-body neuroprosthetic

    BMI components

    Large-scale neuronal recordings

    BMI decoders

    Bimanual control

    Bipedal locomotion

    Posture and balance

    Functional electrical stimulation

    Sensorized neuroprosthetic

    A whole-body exoskeleton

    Chapter 4: Biocompatible multichannel electrodes for long-term neurophysiological studies and clinical therapy—Novel concepts and design

    The physiological state

    State of the art

    A widened concept of biocompatibility

    Novel electrode constructs and implantation procedures

    Concluding remarks

    Chapter 5: Deep brain stimulation

    Deep brain stimulation: A genuine brain-device interface

    New brain electrode interfaces

    Three-dimensional array of electrodes: 3D high-frequency stimulation for field shaping

    From DBS to ECoG recording: Brain–machine interface neuroprosthetics for deficit compensation

    Conclusion

    Chapter 6: Deep brain stimulation

    Introduction

    Conclusion

    Chapter 7: Development of neuromodulation treatments in a large animal model—Do neurosurgeons dream of electric pigs?

    Introduction

    The Göttingen minipig as a neurobiological research animal

    Neuroimaging in the Göttingen minipig

    Neurosurgery in the Göttingen minipig

    Neural and stem cell transplantation in the Göttingen minipig

    Deep brain stimulation in the Göttingen minipig

    Spinal cord stimulation in the Göttingen minipig

    Conclusion and perspectives

    Chapter 8: A few examples of the contribution of animal research in rodents for clinical application of deep brain stimulation

    Introduction

    Nonmotor functions in PD

    DBS for psychiatric disorders

    General conclusion

    Chapter 9: Cochlear implants

    Introduction

    Present-day cochlear implants

    Importance of brain function in determining outcomes

    A “top-down” or “cognitive neuroscience” approach to implant designs

    Questions raised by the top-down approach

    Chapter 10: Multimodal, longitudinal assessment of intracortical microstimulation

    Introduction

    Background

    Experimental overview

    Behavioral thresholds

    Impedance

    Histology

    Conclusion and future work

    Chapter 11: The functional consequences of chronic, physiologically effective intracortical microstimulation

    Introduction

    Methods

    Results

    Discussion

    Chapter 12: Reducing surface area while maintaining implant penetrating profile lowers the brain foreign body response to chronically implanted planar silicon microelectrode arrays

    Introduction

    Methods

    Results

    Discussion

    Conclusion

    Chapter 13: Can histology solve the riddle of the nonfunctioning electrode?

    General background

    Implant size

    Fixation mode

    Functional distance

    Implantation time

    Implant size versus fixation mode over time

    Relation between neurons and reactive cell capsule

    Strategies for a tethered design

    Conclusions

    Chapter 14: Changes in CNS structures after spinal cord lesions

    Reorganization of cortical areas after incomplete SCI

    Reorganization of descending pathways after incomplete SCI

    Changes in the spinal circuitry after SCI

    Chapter 15: Modeling the potentiality of spinal-like circuitry for stabilization of a planar arm system

    Introduction

    Methods

    Results

    Discussion

    Chapter 16: Advances in the use of electrical stimulation for the recovery of motor function

    Introduction

    Command channel for the MNP

    Physiological-like electrical stimulation

    Artificial control for MNPs: Cloning biological control

    Sensor systems

    Conclusions

    Chapter 17: Intraspinal microstimulation for the recovery of function following spinal cord injury

    Introduction

    Use of intraspinal microstimulation for restoring leg movements

    The movements recruited by ISMS

    The stability of ISMS implants

    Moving toward clinical application

    Conclusions

    Chapter 18: Interfacing neurons with carbon nanotubes:

    Introduction

    The biocompatibility of CNT-based substrates and the impact of CNTs on nerve cell signaling

    CNTs as interfaces for neuronal stimulation and recording: improving electrode performance by CNTs

    The impact of CNTs on neuronal morphology and growth

    Conclusions

    Chapter 19: Nanomodified surfaces and neurite outgrowth

    Introduction

    Methods

    Results and discussion

    Conclusions

    Chapter 20: Direct local polymerization of poly(3,4-ethylenedioxythiophene) in rat cortex

    Introduction

    Materials and methods

    Results and discussion

    Conclusions

    Subject Index

    Volume in series

Product details

  • No. of pages: 296
  • Language: English
  • Copyright: © Elsevier Science 2011
  • Published: August 21, 2011
  • Imprint: Elsevier Science
  • eBook ISBN: 9780444538161
  • Hardcover ISBN: 9780444538154
  • About the Serial Volume Editors

    Jens Schouenborg

    Affiliations and Expertise

    Lund University, Sweden

    Martin Garwicz

    Affiliations and Expertise

    Lund University, Sweden

    Nils Danielsen

    Affiliations and Expertise

    Lund University, Sweden