Although problems relating to hyperthermia and heat stroke are well known since biblical times, until now the influence of heat or hyperthermia on the central nervous system has not been well documented. This book is the first to describe in detail the influences of hyperthermia on the CNS using the modern technology which has developed in the last 50 years in neuroscience. Hyperthermia is a common feature during fever, radiotherapy of tumours and exercise in hot environment. Statistically, hyperthermia and/or heat stroke is currently recognised as the third largest killer in America after head and spinal trauma and heart failure. However, studies on the mechanisms of heat-induced death or damage to the CNS are still lacking. This book aims to define the probable mechanisms of brain damage in hyperthermia which could be responsible for death of victims. Rational therapeutic measures based on the experimental findings are also described.

The most important new aspect of the CNS function in hyperthermia suggests that the basic mechanisms of cell injury appears to be quite similar in nature. The severity of cell injury depends chiefly on the magnitude of the primary insult. Thus, it appears that hyperthermic brain injury is similar to the situation of trauma, ischemia and infarction. Baring this in mind, this book describes suitable models for hyperthermic injury which could be highly relevant to the study of mechanisms of cell injury in the CNS and to test various neuroprotective agents which may be found useful in the treatment of various traumatic, ischemic or degenerative diseases.

In general the book will increase our basic understanding of brain function in hot environment and increase our awareness regarding heat as an important factor influencing our brain function at a time when global warming is described as a potential hazard to the biological system.

This book is a refereed collection of 24 chapters written by several eminent scientists from different

Table of Contents

List of contributors. Preface. I. Basic Aspects. Cellular mechanisms of temperature sensitivity in hypothalamic neurons (J.A. Boulant). Cell biology and the functions of thermosensitive neurons in the brain (T. Hori, T. Katafuchi). Spinal neuronal thermosensitivity in vivo and in vitro in relation to hypothalamic neuronal thermosensitivity (E. Simon et al.). Neuronal networks controlling thermoregulatory effectors (K. Kanosue et al.). Plasticity of hypothalamic temperature-sensitive neurons (F.-K. Pierau et al.). II. Pharmacological Aspects. Role of nitric oxide in temperature regulation (H.A. Schmid et al.). Pathophysiology of opioids in hyperthermic states (A.A. Romanovsky, C.M. Blatteis). Prostaglandins and fever (A.S. Milton). Brain eicosanoids and LPS fever: species and age differences (V. Fraifeld, J. Kaplanski). Biogenic amines and thermoregulatory changes (E. Zeisberger). Immunological and neuroendocrine modulation of fever in stress (J. Roth). The effects of drugs on thermoregulation during exposure to hot environments (P. Lomax, E. Schönbaum). III. Molecular Aspects. Heat shock protein response in the central nervous system following hyperthermia (J. Westman, H.S. Sharma). Glial reactions in the central nervous system following heat stress (J. Cervós-Navarro et al.). Prostaglandin (PG) system in the brain: sites of biosynthesis and sites of action under normal and hyperthermic states (K. Matsumura et al.). Nitric oxide and carbon monoxide in the brain pathology of heat stress (H.S. Sharma et al.). IV. Pathophysiological Aspects. Hyperthermia and the central nervous system (P. Sminia, M.C.C.M. Hulshof). Pathophysiology of brain edema and cell changes following hyperthermic brain injury (H.S. Sharma et al.). Blood–brain barrier permeability during hyperthermia (R.R. Shivers, J.A. Wijsman). Cytokines and


© 1998
Elsevier Science
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About the editors

H.S. Sharma

Affiliations and Expertise

Laboratory of Neuroanatomy, Department of Anatomy, Uppsala University Biomedical Centre, S-751 23 Uppsala, Sweden

J. Westman

Affiliations and Expertise

Uppsala Experimental CNS Injury Group, Laboratory of Neuroanatomy, Department of Anatomy, Uppsala University Biomedical Centre, S-751 23, Uppsala, Sweden