Most recent volume


Volume 9. Epigenetics of Chronic Pain

Published: 1st January 2019 Series Volume Editors: Guang Bai Ke Ren

In recent years, epigenetic regulation of gene expression has been shown to play a central role in managing human pain sensitivity. Findings show that expression of many genes critical to increases or decreases in pain sensitivity are indeed regulated by DNA methylation and its enzymes, histone-involved chromatin remodeling, and noncoding RNAs, mainly microRNAs.

With Epigenetics of Chronic pain, Editors Guang Bai and Ke Ren have compiled the first applied, comprehensive volume on the role of epigenetics in chronic pain sensitivity, providing a detailed but accessible view of the field from basic principles to clinical application. Leading international researchers from across academia, clinical settings, and the pharmaceutical industry discuss essential mechanisms of chronic pain epigenetics - including the molecular processes of chromatin remodeling, histone modifications, microRNAs and noncoding RNAs - involved in regulating genes tied to pain sensitivity. The influence of epigenetics in inflammatory, neuropathic, visceral, and other pain models is examined in-depth, with data derived principally from epigenetic studies on peripheral and central mechanisms of pain sensitivity in animal models and clinical cases studies. Studies and case examples cited highlight therapeutic pathways of significance and next steps for researchers to develop epigenetic-based treatments for chronic pain.

Epigenetics of Chronic Pain synthesizes our current understanding of epigenetic regulation of chronic pain in an accessible and clinically relevant format, enabling clinicians, researchers, and pharmacologists to better understand and treat chronic pain.

Additional volumes


Volume 8. Stem Cell Epigenetics

Published: 1st November 2018 Series Volume Editors: Eran Meshorer Giuseppe Testa

Volume 7. Chromatin Signaling and Neurological Disorders

Published: 1st November 2018 Series Volume Editor: Olivier Binda

Volume 6. Epigenetics in Human Disease

Published: 18th May 2018 Editor: Trygve Tollefsbol

Volume 5. The Epigenetics of Autoimmunity

Published: 28th April 2018 Editor: Rongxin Zhang

Volume 4. Epigenetics of Aging and Longevity

Published: 13th November 2017 Editors: Alexey Moskalev Alexander M. Vaiserman

Volume 3. Epigenetic Mechanisms in Cancer

Published: 7th November 2017 Editor: Sabita Saldanha

Volume 2. Nuclear Architecture and Dynamics

Published: 20th October 2017 Editors: Christophe Lavelle Jean-Marc Victor

Volume 1. Cancer and Noncoding RNAs

Published: 2nd October 2017 Editors: Jayprokas Chakrabarti Sanga Mitra Series Editor: Trygve Tollefsbol

DNA Methylation and Complex Human Disease

Published: 3rd September 2015 Author: Michel Neidhart

Epigenetics in Human Disease

Published: 26th July 2012 Editor: Trygve Tollefsbol