Series: Tetrahedron Organic Chemistry

The Tetrahedron Organic Chemistry series was established in 1983. The Series Editors are Professor Sir Jack Baldwin FRS (University of Oxford), Professor Robert M. Williams (Colorado State University) and Professor Jan-Erling Bäckvall (University of Stockholm). In the first instance, please submit any proposals for a new book for the series to [chemistry@elsevier.com](mailto:chemistry@elsevier.com). The Elsevier Tetrahedron Organic Chemistry Series is a topical series of monographs by world-renowned scientists in several fields of organic chemistry. The Tetrahedron Organic Chemistry Series has been very successful in providing some of the very best scholarly works in these topical areas that have proven to be of lasting quality as indispensable reference sources. These books have provided the practicing researcher, student and scholar with an invaluable source of comprehensive reviews in organic chemistry, predominantly in the areas of synthesis and structure determination, including: * Reagents * Reaction mechanisms * Molecular Diversity * Asymmetric Synthesis * Multi-dimensional nmr * Enzymatic Synthesis * Organometallic Chemistry * Biologically Important Molecules
Book Series: Palladium in Heterocyclic Chemistry

Most recent volume


Volume 26. Palladium in Heterocyclic Chemistry

Published: 20th October 2006 Editors: Jie Jack Li Gordon Gribble
Palladium chemistry, despite its immaturity, has rapidly become an indispensable tool for synthetic organic chemists. Heterocycles are of paramount importance in the pharmaceutical industry and palladium chemistry is one of the most novel and efficient ways of making heterocycles. Today, palladium-catalyzed coupling is the method of choice for the synthesis of a wide range of biaryls and heterobiaryls. The number of applications of palladium chemistry to the syntheses of heterocycles has grown exponentially.
These developments highlight the need for a monograph dedicated solely to the palladium chemistry in heterocycles and this book provides a comprehensive explanation of the subject. The principal aim of the book is to highlight important palladium-mediated reactions of heterocycles with emphasis on the unique characteristics of individual heterocycles.
1. Palladium chemistry of heterocycles has its “idiosyncrasies” stemming from their different structural properties from the corresponding carbocyclic aryl compounds. Even activated chloroheterocycles are sufficiently reactive to undergo Pd-catalyzed reactions. As a consequence of &agr and &bgr activation of heteroaryl halides, Pd-catalyzed chemistry may take place regioselectively at the activated positions, a phenomenon rarely seen in carbocyclic aryl halides. In addition, another salient peculiarity in palladium chemistry of heterocycles is the so-called "heteroaryl Heck reaction". For instance, while intermolecular palladium-catalyzed arylations of carbocyclic arenes are rare, palladium-catalyzed arylations of azoles and many other heterocycles readily take place. Therefore, the principal aim of this book is to highlight important palladium-mediated reactions of heterocycles with emphasis on the unique characteristics of individual heterocycles.
2. A myriad of heterocycles are biologically active and therefore of paramount importance to medicinal and agri

Additional volumes


Volume 25. Microwave-assisted Organic Synthesis

Published: 6th December 2005 Author: D. Bogdal

Volume 25. Microwave-assisted Organic Synthesis

Published: 2nd December 2005 Author: D. Bogdal

Volume 24. Molecular Diversity and Combinatorial Chemistry

Published: 17th September 2004 Author: Michael Pirrung

Volume 24. Molecular Diversity and Combinatorial Chemistry

Published: 11th September 2004 Author: Michael Pirrung

Volume 23. Organolithiums: Selectivity for Synthesis

Published: 12th July 2002 Author: Jonathan Clayden

Volume 23. Organolithiums: Selectivity for Synthesis

Published: 12th July 2002 Author: Jonathan Clayden

Volume 22. Organic Syntheses Based on Name Reactions

Published: 12th July 2002 Authors: C Stumer Alfred Hassner

Volume 21. Biodiversity and Natural Product Diversity

Published: 15th May 2002 Author: F Pietra

Volume 21. Biodiversity and Natural Product Diversity

Published: 15th May 2002 Author: F Pietra

Volume 20. Palladium in Heterocyclic Chemistry

Published: 7th November 2000 Authors: Gordon Gribble Jie Jack Li

Volume 20. Palladium in Heterocyclic Chemistry

Authors: Gordon Gribble Jie Jack Li

Volume 19. High-Resolution NMR Techniques in Organic Chemistry

Published: 24th December 1999 Author: T. Claridge

Volume 18. Ligand Coupling Reactions with Heteroatomic Compounds

Published: 7th October 1998 Series Volume Editor: Finet

Volume 17. Solid-Supported Combinatorial and Parallel Synthesis of Small-Molecular-Weight Compound Libraries

Published: 2nd October 1998 Editors: D. Obrecht J.M. Villalgordo

Volume V. Organotransition Metal Chemistry

Editor: J E Baldwin Author: S. G. Davies

Volume .. Synthesis of Optically Active Alpha-Amino Acids

Editor: J E Baldwin Author: R. M. Williams

Volume .. Selenium Reagents & Intermediates in Organic Synthesis

Editor: J E Baldwin Author: C. Paulmier

Volume 16. Advanced Problems in Organic Reaction Mechanisms

Published: 4th December 1997 Series Volume Editor: McKillop

Volume 15. Expanded, Contracted & Isomeric Porphyrins

Published: 21st August 1997 Authors: J.L. Sessler S.J. Weghorn

Volume 14. Principles of Asymmetric Synthesis

Published: 21st November 1996 Authors: R.E. Gawley J. Aubé

Volume 13. The Chemistry of C-Glycosides

Published: 21st December 1995 Editors: D.E. Levy C. Tang

Volume 12. Enzymes in Synthetic Organic Chemistry

Published: 17th June 1994 Authors: Wong Whitesides

Volume 11. Organic Syntheses Based on Name Reactions and Unnamed Reactions

Published: 22nd July 1994 Editor: J E Baldwin Authors: Alfred Hassner C Stumer

Volume 10. Sulphones in Organic Synthesis

Published: 28th January 1993 Editor: J E Baldwin Author: N S. Simpkins

Volume 9. Conjugate Addition Reactions in Organic Synthesis

Published: 15th June 1992 Editor: J E Baldwin Author: P. Perlmutter

Volume 8. Cycloaddition Reactions in Organic Synthesis

Published: 28th September 1990 Author: W. Carruthers

Volume 2. High-Resolution NMR Techniques in Organic Chemistry

Published: 5th November 2008 Author: Timothy D.W. Claridge

Modern NMR Techniques for Chemistry Research

Published: 9th February 1987 Editor: J E Baldwin Author: A.E. Derome