Series: International Encyclopedia of Pharmacology and Therapeutics

Most recent volume


Volume . Anticancer Drugs: Antimetabolite Metabolism and Natural Anticancer Agents

Published: 28th January 1994 Editors: G. Powis
There are over 50 clinically approved anticancer drugs, as well as numerous steroidal agents, and in addition there are many new anticancer drugs in various stages of preclinical and clinical development. The anticancer drugs embody a diverse array of chemical structures. The purpose of this two volume publication is to provide a comprehensive review of the metabolism of anticancer drugs. The authors, each expert in their fields, have attempted to emphasize the relation of metabolism to the therapeutic and toxic effects of anticancer drugs, drawing whenever possible on human studies. There is a critical need for new approaches to treating cancer and it is certain that we will see an increasing number of new drugs with exotic chemical structures used for chemotherapy and perhaps chemoprevention. To understand the mechanisms of action of any drug it is important to know how the drug is transformed in the body, either into active metabolites or inactive products to be excreted. With this information the success or failure of a drug in arresting cancer cell growth can be assessed, and perhaps more effective drugs designed. Medical science has taken the first important steps toward controlling cancer. The use and study of current chemotherapeutic drugs has taught us much about how toxic chemicals can be employed to treat human cancer; comprehending the underlying metabolism of these drugs should facilitate even better modalities of treatment for the future.

Additional volumes


Intracellular Messengers

Published: 20th May 1993 Editors: C.M. Taylor

Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells

Published: 12th March 1993 Editors: T.E. Gram

Pharmacogenetics of Drug Metabolism

Published: 1st April 1992 Editors: W. Kalow

Snake Toxins

Published: 28th October 1991 Editors: A.L. Harvey

Psychopharmacology of Anxiolytics and Antidepressants

Published: 15th August 1991 Editors: S.E. File

Novel Peripheral Neurotransmitters

Published: 18th July 1991 Editors: C. Bell

Thermoregulation: Pathology, Pharmacology and Therapy

Published: 28th February 1991 Editors: E. Schonbaum P. Lomax

Thermoregulation: Physiology and Biochemistry

Published: 12th February 1991 Editors: E. Schonbaum P. Lomax

Anti-Rheumatic Drugs

Published: 28th September 1990 Editors: Michael Orme

Psychotropic Drugs of Abuse

Published: 27th April 1990 Editors: D.J.K. Balfour

Ornithine Decarboxylase

Published: 26th April 1989 Editors: Shin-ichi Hayashi

Inhibitors of Ribonucleoside Diphosphate Reductase Activity

Published: 12th December 1988 Editors: Joseph G. Cory Ann H. Cory

Antibiotic Inhibitors of Bacterial Cell Wall Biosynthesis

Published: 18th January 1988 Editors: D.J. Tipper

Mechanisms of Cellular Transformation by Carcinogenic Agents

Published: 9th October 1987 Editors: D. Grunberger S.P. Goff

The Toxicology of Molluscicides

Published: 22nd September 1987 Editors: G. Webbe

The Role of Calcium in Drug Action

Published: 27th February 1987 Editors: M. Denborough

Membrane Transport of Antineoplastic Agents

Published: 8th September 1986 Editors: I.D. Goldman

Cell Cycle Effects of Drugs

Published: 12th June 1986 Editors: L.A. Dethlefsen

Methods of Drug Delivery

Published: 1st June 1986 Editors: G. M. Ihler

Neuropeptides & Behavior

Published: 1st April 1986 Editors: D. De Wied W. H. Gispen T. J. B. Van Wimersma Greidanus

Differential Toxicities of Insecticides and Halogenated Aromatics

Published: 1st September 1984 Editors: F. Matsumura

Nicotine and the Tobacco Smoking Habit

Published: 1st July 1984 Editors: D.J.K. Balfour

The Chemotherapy of Psoriasis

Published: 29th February 1984 Editors: H.P. Baden