<EM>The Alkaloids</EM> is a unique series that has been providing comprehensive reviews on all aspects of alkaloids for the past 60 years. This internationally acclaimed series provides, through its distinguished authors, up-to-date and detailed coverage of the chemistry, biology, biosynthesis and clinical aspects of alkaloids.</P><P>About the Editor: Hans-Joachim Knölker, Department Chemie, Technische Universität Dresden, Germany.</P><P>To view individual chapters for The Alkaloids, please visit Science Direct.</P><P>Praise for the Series: <br>"Authoritative, precise, thorough, and above all, permeated with enthusiasm." <strong>--JOURNAL OF PHARMACEUTICAL SCIENCES</strong>
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Chapter 2 is a fascinating review of the supercritical fluid extraction of alkaloids. This technique using basic modifiers, provides an alternative method for the extraction of alkaloids.
Chapter 3 summarizes recent advances in the synthesis of Amaryllidaceae alkaloids, an important class of naturally-occurring bases and neutral compounds. The increased activity in the synthesis of these alkaloids over the last decade is undoubtedly due to the fact that certain members of this family possess interesting and useful biological properties. Elegant syntheses, chiral and otherwise, of structures incorporating many asymmetric centres are reviewed.
Chapter 4 reviews radical cyclization reactions in the total synthesis of indole alkaloids. The use of free radical chemistry in the synthesis of alkaloids has grown markedly because of the mild reaction conditions, tolerance of a wide variety of functional groups, and the good stereoselectivities.
Each chapter in this volume has been reviewed by at least one specialist in the field.