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Volume 33. Ion Channel Regulation

Published: 8th April 1999 Serial Volume Editors: David Armstrong Sandra Rossie Serial Editors: Paul Greengard Angus Nairn Shirish Shenolikar
Volume 33 reviews the current understanding of ion channel regulation by signal transduction pathways. Ion channels are no longer viewed simply as the voltage-gated resistors of biophysicists or the ligand-gated receptors of biochemists. They have been transformed during the past 20 years into signaling proteins that regulate every aspect of cell physiology. In addition to the voltage-gated channels, which provide the ionic currents to generate and spread neuronal activity, and the calcium ions to trigger synaptic transmission, hormonal secretion, and muscle contraction, new gene families of ion channel proteins regulate cell migration, cell cycle progression, apoptosis, and gene transcription, as well as electrical excitability. Even the genome of the lowly roundworm Caenorhabditis elegans encodes almost 100 distinct genes for potassium-selective channels alone. Most of these new channel proteins are insensitive to membrane potential, yet in humans, mutations in these genes disrupt development and increase individual susceptibility to debilitating and lethal diseases. How do cells regulate the activity of these channels? How might we restore their normal function? In Ion Channel Regulation, many of the experts who pioneered these discoveries provide detailed summaries of our current understanding of the molecular mechanisms that control ion channel activity.

Additional volumes

Volume 30. Calcium Regulation of Cellular Function

Published: 21st July 1998 Serial Volume Editor: Anthony Means Serial Editors: Paul Greengard Angus Nairn Shirish Shenolikar

Volume 31. Signal Transduction in Health and Disease

Published: 21st July 1998 Serial Volume Editors: Jackie Corbin Sharron Francis Serial Editors: Paul Greengard Angus Nairn Shirish Shenolikar

Volume 29. Molecular & Cellular Mechanisms of Neurotransmitter Release

Published: 12th February 1994 Serial Volume Editors: Lennart Stjarne Paul Greengard Sten Grillner Tomas Hokfelt Serial Editors: Angus Nairn Shirish Shenolikar