Series: Advances in Oncobiology

In the last few years considerable progress has been made in our understanding of molecular oncology and we are beginning to see how this understanding can be translated into strategies for treatment or prevention. It is now widely recognized that tumor suppressor genes play an important role in the development of tumors and that oncogene mutation represents only one mechanism which leads to cancer. In their seminal study of colon cancer, Vogelstein and co-workers were able to identify several genetic events, notably activation of a dominant oncogene (ras) and inactivation of several tumor suppressor genes including p53 and DCC that contribute to cancer development and progression. These events occur in clonal populations of adenoma cells. Whether products of tumor suppressor genes and oncogenes interact with each other is not yet known with certainty.
Book Series: The Oncobiology of the Prostate

Most recent volume

Volume 3. The Oncobiology of the Prostate

Published: 20th December 2000 Editors: D.P. Wood K.V. Honn
Prostate cancer (PCa) is the most common newly diagnosed cancer among men in the United States today. With the advent of the prostate-specific antigen (PSA) test, the number of newly diagnosed cases has increased tremendously. The rates of PCa have increased so dramatically over the last decade that the age-adjusted incidence rate of PCa is no greater than that for any other cancer among men in the United States. Although PCa rates have risen steadily since 1973, there has been a dramatic acceleration in the late 1980s which has been associated with the introduction and use of PSA for screening and early detection. There is now some evidence that the rates may be levelling off and even decreasing in some areas. After lung cancer, PCa is the leading cause of death due to cancer in men in the United States. Although PCa can occur in younger men, it is essentially a cancer of elderly men. The highest rates of PCa in the world occur among African-American men in the United States. African-Americans have higher rates than Caucasians at all age levels in the United States, and adjusting for social-economic status does not appear to account for this difference to any appreciable extent. There is no clear reason why PCa rates are so much greater among African-Americans compared with Caucasians in the United States. The reported rates in Africans are substantially lower than those of an African-American, suggesting that environmental factors have an influence on PCa. In spite of this substantial impact on our society. PCa remains a relatively understudied disease, with an essentially unknown etiology.
The reviews contained in this book are by no means exhaustive. We have, however, attempted to provide information regarding the pathology of prostate cancer, the status of diagnostic and prognostic markers, as well as a discussion of our understanding of the molecular basis for the disease. The biology of prostate cancer is covered with a discussion on the role of apoptosis in prostate cancer and the suggestion of it being the target for new therapeutic development, as well as the role played by integrins and angiogenesis. The status of current therapies, both hormonal and chemotherapy, are also discussed. This volume should provide a useful background for individuals wishing to commence an in-depth understanding of prostate cancer.

Additional volumes

Volume 2. Breast Cancer

Published: 25th August 1998 Editors: W.P. Peters D.W. Visscher

Volume 1. Some Aspects of Oncology

Published: 25th March 1997 Editors: G. Heppner Edward Bittar