Series: Advances in Oncobiology

In the last few years considerable progress has been made in our understanding of molecular oncology and we are beginning to see how this understanding can be translated into strategies for treatment or prevention. It is now widely recognized that tumor suppressor genes play an important role in the development of tumors and that oncogene mutation represents only one mechanism which leads to cancer. In their seminal study of colon cancer, Vogelstein and co-workers were able to identify several genetic events, notably activation of a dominant oncogene (ras) and inactivation of several tumor suppressor genes including p53 and DCC that contribute to cancer development and progression. These events occur in clonal populations of adenoma cells. Whether products of tumor suppressor genes and oncogenes interact with each other is not yet known with certainty.
Book Series: The Oncobiology of the Prostate

Most recent volume


Volume 3. The Oncobiology of the Prostate

Published: 20th December 2000 Editors: D.P. Wood K.V. Honn
Contents. List of Contributors. Introduction (D.P. Wood, Jr. and K.V. Honn). Pathology of Prostate Cancer (D.J. Grignon and W.A. Sakr). Animal Model Systems for the Study of Prostate Cancer (M.L. Cher, J. Harb, and J. Nemeth). Tumor Markers for Prostate Cancer (X. Gao and K.V. Honn). Molecular Biology of Prostate Cancer: Tumor Suppressor Genes (X. Gao and K.V. Honn). Apoptosis and Prostate Cancer (K. Tang and K.V. Honn). Angiogenesis in Prostate Cancer (D. Nie and K.V. Honn). Molecular Progression of Prostate Cancer (S. Sirvastava and J.W. Moul). Biology of Prostate Cancer Bone Marrow Metastasis (J.A. Nemeth and M.L. Cher). Integrins in Prostate Cancer Metastasis (M. Trikha and K.V. Honn). Neoadjuvant Hormonal Therapy Prior to Radical Prostatectomy: Promises and Pitfalls (M.E. Gleave and S.L. Goldenberg). Current Management of Hormone-Refractory Prostate Cancer (O. Sartor and W.D. Figg). Index.

Additional volumes


Volume 2. Breast Cancer

Published: 25th August 1998 Editors: W.P. Peters D.W. Visscher

Volume 1. Some Aspects of Oncology

Published: 25th March 1997 Editors: G. Heppner Edward Bittar