Series: Advances in Molecular and Cell Biology

In this serie we hope to capture some of the excitement and vitality that characterizes the state of Molecular and Cell Biology today. We have chosen an approach in which individual researchers at the forefront of cell biology have been invited to highlight some of the most important research and technical advances in their research. While these articles will integrate these advances into the large picture of Molecular Cell Biology research, the authors have not been burdened with the task of reviewing all advances in their fields or assembling an exhaustive citation list from which the reader can develop a bibliography of all work published on a particular topic. Instead, we have tried to choose a format in which individual researchers will do what they do best: to explain the areas in which are shaping that field and influencing the direction of scientific thought and experimentation.
Book Series: Chloride Movements Across Cellular Membranes

Most recent volume


Volume 38. Chloride Movements Across Cellular Membranes

Published: 8th January 2007 Serial Volume Editor: Michael Pusch
  • Contributors to Volume 38
  • Preface
  • Chapter 1: Chloride–Transporting Proteins in Mammalian Organisms: An Overview
  • Chapter 2: Physiological Functions of the CLC Chloride Transport Proteins
    • I INTRODUCTION
    • II PHYSIOLOGICAL FUNCTION OF CLC–0 AND MAMMALIAN CLC PROTEINS
    • III CLC PROTEINS IN MODEL ORGANISMS
    • IV SUMMARY AND OUTLOOK
  • Chapter 3: Structure and Function of CLC Chloride Channels and Transporters
    • I THE STRUCTURE OF CLC–EC1, A BACTERIAL CLC TRANSPORTER
    • II STRUCTURAL CONSERVATION AMONG THE CLCS
    • III ION SELECTIVITY, PERMEATION AND BINDING
    • IV A MULTI–ION PORE
    • V CHANNELS AND TRANSPORTERS: WHERE IS THE DIFFERENCE?
    • VI FUNCTION OF THE CLC TRANSPORTERS
    • VII SPECULATIVE MODELING
    • VIII CLC CHANNEL GATING
    • IX THE ROLE OF THE C–TERMINAL DOMAIN OF CLC CHANNELS: RECENT DEVELOPMENTS
    • X CONCLUSIONS AND OUTLOOK
    • ACKNOWLEDGMENTS
  • Chapter 4: Pharmacology of CLC Chloride Channels and Transporters
    • I INTRODUCTION
    • II THE PHARMACOLOGY OF THE MACROSCOPIC SKELETAL MUSCLE Cl− CONDUCTANCE gCl
    • III NEW MOLECULES TARGETING ClC-1 IDENTIFIED USING HETEROLOGOUS EXPRESSION
    • IV MECHANISM OF BLOCK OF MUSCLE TYPE CLC CHANNELS BY CLOFIBRIC ACID DERIVATIVES
    • V THE BINDING SITE FOR 9-AC AND CPA ON ClC-1 AND ClC-0 AND USE OF CPA AS A TOOL TO EXPLORE THE MECHANISMS OF GATING OF ClC-0
    • VI PHARMACOLOGY OF CLC-K CHANNELS
    • VII OTHER CLC CHANNELS AND OTHER BLOCKERS
    • VIII POTENTIAL OF HAVING BLOCKERS OF ClC-2, ClC-3, ClC-5, ClC-7: OUTLOOK
    • ACKNOWLEDGMENTS
  • Chapter 5: The Physiology and Pharmacology of the CFTR Cl− Channel
    • I INTRODUCTION
    • II THE MOLECULAR PHYSIOLOGY OF CFTR
    • III THE CELLULAR PHYSIOLOGY OF CFTR
    • IV THE ROLE OF CFTR IN EPITHELIAL PHYSIOLOGY
    • V THE PATHOPHYSIOLOGY OF CFTR
    • VI THE PHARMACOLOGY OF CFTR
    • VII CONCLUSIONS
    • ACKNOWLEDGMENTS
  • Chapter 6: Gating of Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel
    • I CFTR OVERVIEW
    • II REGULATION OF CFTR BY PHOSPHORYLATION/DEPHOSPHORYLATION
    • III CFTR IS AN ATPASE
    • IV STRUCTURAL BIOLOGY OF ABC TRANSPORTERS
    • V METHODS USED TO STUDY CFTR GATING
    • VI CFTR GATING BY ATP
    • VII UNSETTLED ISSUES AND FUTURE DIRECTIONS
    • ACKNOWLEDGMENTS
  • Chapter 7: Functional Properties of Ca2+–Dependent Cl− Channels and Bestrophins: Do They Correlate?
    • I SUMMARY
    • II INTRODUCTION
    • III FUNCTIONAL PROPERTIES OF CaCCs
    • IV MOLECULAR CANDIDATES OF CaCCs
    • V FUNCTIONAL PROPERTIES OF BESTROPHINS
    • VI CONCLUDING REMARKS
    • ACKNOWLEDGMENTS
  • Chapter 8: Cell Volume Homeostasis: The Role of Volume–Sensitive Chloride Channels
    • I INTRODUCTION
    • II CELL VOLUME HOMEOSTASIS
    • III VOLUME–SENSITIVE Cl− CHANNELS
    • IV CONCLUDING REMARKS
  • Chapter 9: GABAergic Synaptic Transmission
    • I POSTSYNAPTIC GABA RESPONSES
    • II MOLECULAR COMPOSITION AND FUNCTION OF GABAERGIC/GLYCINERGIC SYNAPSES
    • III MODULATION OF SYNAPTIC FUNCTIONS THROUGH ENDOGENOUS SUBSTANCES AND DRUGS
    • IV PERSPECTIVE: SPECIFICITY OF GABAERGIC AND GLYCINERGIC SIGNALING IN DEFINED NETWORKS
  • Chapter 10: Physiology of Cation–Chloride Cotransporters
    • I INTRODUCTION
    • II THE CATION–CHLORIDE COTRANSPORTER FAMILY
    • III CATION–CHLORIDE COTRANSPORTERS IN THE NERVOUS SYSTEM
    • IV CATION–CHLORIDE COTRANSPORTERS IN THE INNER EAR
    • V CATION–CHLORIDE COTRANSPORTERS IN THE KIDNEY
    • VI CATION–CHLORIDE COTRANSPORTERS IN RBCs
    • VII CATION–CHLORIDE COTRANSPORTER AND CANCER
    • VIII CATION–CHLORIDE COTRANSPORT AND HYPERTENSION
    • IX CONCLUDING REMARKS
  • Chapter 11: Plasma Membrane Cl−/HCO3− Exchange Proteins
    • I INTRODUCTION
    • II THE Cl−/HCO3− EXCHANGERS
    • III DISPUTED Cl−/HCO3− EXCHANGERS
    • IV STRUCTURE
    • V REGULATION AND INHIBITION OF Cl−/HCO3− EXCHANGE
    • VI PATHOPHYSIOLOGY
    • ACKNOWLEDGMENTS
  • Chapter 12: Orchestration of Vectorial Chloride Transport by Epithelia
    • I INTRODUCTION
    • II EPITHELIAL CELL STRUCTURE AND ORGANIZATION
    • III JUNCTIONAL PROTEINS: AN OVERVIEW
    • IV CHLORIDE TRANSPORTING PROTEINS IN EPITHELIA: CHANNELS, TRANSPORTERS, AND ALL THINGS IN BETWEEN
    • V PDZ PROTEINS: WHAT ARE THEY? WHERE ARE THEY? WHAT DO THEY DO?
    • VI TWO DISEASES INVOLVING EPITHELIAL CHLORIDE TRANSPORT
    • VII SUMMARY
  • Index

Additional volumes


Volume 37. Aspects of the Cytoskeleton

Published: 21st November 2006 Serial Volume Editor: Seema Khurana

Volume 36. Caveolae and Lipid Rafts: Roles in Signal Transduction and the Pathogenesis of Human Disease

Published: 6th July 2005 Editor: Edward Bittar

Volume 35. Perspectives on Lung Endothelial Barrier Function

Published: 9th December 2004 Series Editor: Edward Bittar Author: C.E. Patterson

Volume 31. Non-Neuronal Cells of the Nervous System: Function and Dysfunction

Published: 8th December 2003 Author: L. Hertz

Volume 30. Gap Junctions

Published: 27th December 1999 Editor: E.L. Hertzberg

Volume 29. The Biology of the Pancreatic Cell

Published: 15th April 1999 Editor: S.L. Howell

Volume 28. The Adhesive Interaction of Cells

Published: 31st March 1999 Editors: David Garrod A.J. North M.A.J. Chidgey

Volume 26. Cell Polarity

Published: 25th August 1998 Editor: J.R. Bartles

Volume 27. Intracellular Protein Degradation

Published: 7th August 1998 Editor: A.J. Rivett

Volume 25. Oxyradicals in Medical Biology

Published: 23rd April 1998 Editor: J.M. McCord

Volume 22. Protein Structural Biology in Biomedical Research, Part A

Published: 16th January 1998 Editor: N.M. Allewell Author: C. Woodward

Volume 23. Ion Pumps, Part A

Published: 19th November 1997 Editor: J.P. Andersen

Volume 24. Cell Structure and Signaling

Published: 19th October 1997 Editor: R.H. Getzenberg

Volume 21. In VIVO Footprinting

Published: 22nd August 1997 Editor: I.L. Cartwright

Volume 15. Biochemical Technology, Part A

Published: 6th May 1997 Editor: B. Danielsson Author: L. Bulow

Volume 18. The Platelet

Published: 18th April 1997 Editor: E.G. Lapetina

Volume 20. Mechanisms of Cell Toxicity

Published: 15th April 1997 Author: J.K. Chipman

Volume 19. Thermobiology

Published: 15th April 1997 Author: J.S. Willis

Volume 17. Protein Targeting to Mitochondria

Published: 24th February 1997 Editor: F.U. Hartl

Volume 16. Cell Adhesion

Published: 24th February 1997 Editor: D.R. Colman

Volume 14. Physiological Functions of Cytochrome P450 in Relation to Structure and Regulation

Published: 9th December 1996 Author: C.R. Jefcoate

Volume 13. Cell Cycle

Published: 20th March 1996 Author: Michael Whitaker

Volume 12. Cytoskeleton

Published: 8th January 1996 Author: J. Hesketh

Volume 11. Enzymology IN VIVO

Published: 1st April 1995 Author: K.M. Brindle

Volume 10. Molecular Processes of Photosynthesis

Published: 1st March 1995 Author: J. Barber

Volume 9. Homing Mechanisms and Cellular Targeting

Published: 1st October 1994 Author: B.R. Zetter

Volume 8. Organelles IN VIVO

Published: 1st June 1994 Author: L.B. Chen

Volume 7. Biology of the Cancer Cell

Published: 1st March 1994 Author: G.H. Heppner

Volume 6. Extracellular Matrix

Published: 20th October 1993 Author: H.K. Kleinman

Volume 5. Molecular Immunology

Published: 30th September 1992 Author: K.R. Miller

Volume 4. Advances in Molecular and Cell Biology

Published: 13th August 1992 Editor: Edward Bittar

Volume 3. Advances in Cell Biology

Published: 1st April 1990 Author: K.R. Miller

Volume 2. Advances in Cell Biology

Published: 1st January 1989 Author: K.R. Miller

Volume 1. Advances in Cell Biology

Published: 1st July 1987 Author: K.R. Miller