Series: Advances in Medicinal Chemistry

This series presents first hand accounts of industrial and academic research projects in medicinal chemistry. The overriding purpose is representation of the many organic chemical facets of drug discovery and development. This would include: de novo drug design, organic chemical synthesis, spectroscopic studies, process development and engineering, structure-activity relationships, chemically based drug mechanisms of action, the chemistry of drug metabolism, and drug physical-organic chemistry.

Volumes 1-3 were published by JAI Press under the editorship of Bruce E. Maryanoff and Cynthia A. Maryanoff, R.W. Johnson Pharmaceutical Research Institute.

Volume 4 was published by JAI Press under the editorship of Bruce E. Maryanoff and Allen B. Reitz, R.W. Johnson Pharmaceutical Research Institute.

This series has been discontinued and combined with Progress in Medicinal Chemistry.

Book Series: Advances in Medicinal Chemistry

Most recent volume


Volume 5. Advances in Medicinal Chemistry

Published: 27th December 1999 Editors: A.B. Reitz S.L. Dax
Volume 5 of Advances in Medicinal Chemistry contains four intriguing and detailed accounts of the close interface between synthetic chemistry, structure-activity relationships, biochemistry, and pharmacology. In Chapter 1, there is a comprehensive survey of the immunophilin area specifically focussing on neuroregenerative applications in the central nervous system. In Chapter 2, there is an overview of the development of a potent analgesic compound that works via modulation of neuronal nicotinic acetylcholine receptors. In Chapter 3, there is a description of dopamine D-2 autoreceptor partial agonists as potential therapy for the treatment of schizophrenia. In Chapter 4, there is a summary of the successful program in which potent non-peptide inhibitors of HIV protease from the AIDS virus were developed.

Additional volumes


Volume 4. Advances in Medicinal Chemistry

Published: 1st April 1999 Editors: B.E. Maryanoff A.B. Reitz

Volume 3. Advances in Medicinal Chemistry

Published: 4th January 1996 Editors: B.E. Maryanoff C.A. Maryanoff