Series: Advances in DNA Sequence-Specific Agents

DNA sequence specificity plays a critical role in a number of biological processes, and influences a diverse range of molecular recognition phenomena, including protein-DNA, oligomer-DNA, and ligand -DNA interactions. This series is intended to give the reader an up-to-date view of both established and emergent trends, in research involving DNA-interactive agents with an emphasis on sequence specificity. The series encompasses design, synthesis, application, and analytical methods (including clinical and in vitro) for the study of these critical interactions. Recent topics that have been addressed include the mechanisms of selective DNA-topoisomerase poisoning by anti tumor agents, sequence-specific recognition of DNA by groove-binding drugs and drug-conjugates, DNA-cleaving anti tumor chromoproteins, application of sequence-specific anti sense and anti-gene therapy in oncology, and mimetics of the DNA structure. As our understanding of the genome and proteome expands, general developments in the field of DNA sequence specific interactions are likely to play an increasingly important role. Key developments are likely to involve small molecules with highly specific groove binding, molecules with affinity for unique DNA micro environments, oligonucleotides capable of stabilizing unique DNA architectures, macromolecules which form unique ternary complexes, and molecules which influence the recruitment and assembly of transcription factors. Accordingly, manuscripts have been solicited from experts covering a diverse range of scientific backgrounds, reflecting the cross-disciplinary and dynamic nature of the series.
Book Series: Advances in DNA Sequence-specific Agents

Most recent volume


Volume 4. Advances in DNA Sequence-specific Agents

Published: 17th September 2002 Editor: B.J. Chapman
This series encompasses design, synthesis, application, and analytical methods (including clinical and in vitro) for the study of these critical interactions. As our understanding of the genome and proteome expands, general developments in the field of DNA sequence specific interaction are likely to play an increasingly important role. Accordingly, manuscripts have been solicited from experts covering a diverse range of fields, reflecting the cross-disciplinary and dynamic nature of the series.

Volume 4 describes work on the modification of DNA by AT specific anticancer drugs, DNA alkylation events which involve metabolite generation, DNA sequence recognition by two selective binders, bulged DNA microenvironments as molecular targets, DNA sequence specific binding by short peptides and the analysis of DNA-protein interactions using DNase I footprinting methodology.

Features include:
• Expert contributors from the Biomedical world • Emerging areas of drug design and therapeutic applications • Nucleic acid-protein interactions • Color graphics of molecular modeling analyses • New and emerging methodologies

Additional volumes


Volume 3. Advances in DNA Sequence-specific Agents

Published: 19th November 1997 Editor: M. Palumbo

Volume 2. Advances in DNA Sequence-specific Agents

Published: 9th July 1996 Editor: J.B. Chaires

Volume 1. Advances in DNA Sequence-specific Agents

Published: 24th June 1992 Editor: L.H. Hurley