Series: Advances in Cell Aging and Gerontology

Advances in Cell Aging and Gerontology (ACAG) is dedicated to providing timely review articles on prominent and emerging research in the area of molecular, cellular and organismal aspects of aging and age-related disease. The average human life expectancy continues to increase and, accordingly, the impact of the dysfunction and diseases associated with aging are becoming a major problem in our society. The field of aging research is rapidly becoming the niche of thousands of laboratories worldwide that encompass expertise ranging from genetics and evolution to molecular and cellular biology, biochemistry and behavior. ACAG consists of edited volumes that each critically review a major subject area within the realms of fundamental mechanisms of the aging process and age-related diseases such as cancer, cardiovascular disease, diabetes and neurodegenerative disorders. Particular emphasis is placed upon: the identification of new genes linked to the aging process and specific age-related diseases; the elucidation of cellular signal transduction pathways that promote or retard cellular aging; understanding the impact of diet and behavior on aging at the molecular and cellular levels; and the application of basic research to the development of lifespan extension and disease prevention strategies. ACAG will provide a valuable resource for scientists at all levels from graduate students to senior scientists and physicians.
Sleep and Aging

Most recent volume


Volume 17. Sleep and Aging

Published: 23rd April 2005
Alterations in sleep are common manifestations of aging that can lead to significant health problems and contribute to behavioural problems associated with age-related neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Recent advances have revealed key cellular and molecular mechanisms involved in sleep regulation, and this knowledge is helping to advance an understanding of both the normal functions of sleep and the mechanisms responsible for abnormalities in sleep in various neurological conditions and during normal aging. This volume of Advances in Cell Aging and Gerontology brings together chapters by leaders in the fields of sleep research and the neurobiology of aging. The book starts with chapters describing fundamental aspects of the neurocircuitry involved in sleep, patterns of brain activity during the different stages of sleep and disturbances of sleep during aging. The links between depression, anxiety and insomnia are reviewed in regards to the underlying neurochemical alterations that appear to involve abnormalities in neurotransmitter and neurotrophic factor signalling. The evolutionary basis of sleep is reviewed and the emerging evidence supporting a major role for sleep in learning and memory is described. The bulk of the book focuses on specific sleep disorders associated with aging and age-related neurodegenerative disorders. A comprehensive consideration of this topic is woven through a number of chapters that address both basic research and clinical aspects of sleep abnormalities during aging and in disease. The impact of sleep on the immune system is described. The articles are written in a high level of detail and are comprehensive, thus providing valuable information for a range of scientists and other well-educated people. In particular, the book will be a valuable resource for graduate students, postdoctoral and senior scientists in the fields of sleep, aging, neurodegenerative disorders and learning and mem

Additional volumes


Volume 16. Protein Phosphorylation in Aging and Age-Related Disease

Published: 17th February 2004 Editors: Paul Mark Mattson

Volume 15. Recent Advances in Psychology and Aging

Published: 10th December 2003 Editors: P. Costa I.C. Siegler

Volume 14. Energy Metabolism and Lifespan Determination

Published: 1st December 2003 Editors: M.P. Mattson

Volume 13. Basic Biology and Clinical Impact of Immunosenescence

Published: 1st May 2003 Editors: G. Pawelec

Volume 12. Membrane Lipid Signaling in Aging and Age-Related Disease

Published: 6th May 2003 Editors: M.P. Mattson

Volume 11. Mechanisms of Cardiovascular Aging

Published: 19th November 2002 Editors: T. Hagen

Volume 10. Calcium Homeostasis and Signaling in Aging

Published: 1st October 2002 Editors: M.P. Mattson

Volume 8. Stem Cells: A Cellular Fountain of Youth

Published: 21st August 2002 Editors: M.P. Mattson G. van Zant

Volume 8. Telomerase, Aging and Disease

Published: 12th October 2001 Editors: M.P. Mattson

Volume 7. Interorganellar Signaling in Age-Related Disease

Published: 19th April 2001 Editors: M.P. Mattson

Volume 6. Programmed Cell Death, Volume II

Published: 19th April 2001 Editors: S. Estus V. Rangnekar M.P. Mattson

Volume 5. Programmed Cell Death, Volume I

Published: 18th April 2001 Editors: M.P. Mattson S. Estus V. Rangnekar

Volume 4. The Role of DNA Damage and Repair in Cell Aging

Published: 9th March 2001 Editors: V.A. Bohr B.A. Gilchrest

Volume 3. Genetic Aberrancies and Neurodegenerative Disorders

Published: 28th January 2000 Editors: M.P. Mattson

Volume 2. The Aging Brain

Published: 16th January 1998 Editors: M.P. Mattson J.W. Geddes

Volume 1. Some Aspects of the Aging Process

Published: 17th December 1996 Editors: P.S. Timiras Edward Bittar