Among various other promising antiviral compounds that are currently under development rank the capsid uncoating inhibitors, for the treatment of rhino- and other picornavirus infections, and the acyclic nucleoside phosphonates [i.e. HPMPC or (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine and PMEA or 9-(2-phosphonylmethoxyethyl)adenine] for the treatment of herpesvirus (HSV, VZV, CMV, ?) and retrovirus (HIV, ?) infections.
The purpose of the series, Advances in Antiviral Drug Design, is to regularly provide an account on the chemistry of the new antiviral agents (whether licensed or en route of licensing), and to discuss their structure-activity relationship, width of activity spectrum, and mechanism of action.