Bone Repair Biomaterials - 2nd Edition - ISBN: 9780081024515

Bone Repair Biomaterials

2nd Edition

Regeneration and Clinical Applications

Editors: Kendell Pawelec J. A. Planell S. M. Best D. Lacroix A. Merolli
Paperback ISBN: 9780081024515
Imprint: Woodhead Publishing
Published Date: 1st November 2018
Page Count: 440
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Table of Contents

1. Challenges of bone repair

- Introduction

- Social impact of musculoskeletal disease

- Economic burden of musculoskeletal disease

- Social aspects of dental and maxillofacial conditions

- Some clinical challenges of bone repair

- Conclusions and future trends

- Sources of further information and advice

- References

2. Bone anatomy, physiology and adaptation to mechanical loading

- Introduction

- Macroscopic bone anatomy

- Microscopic bone anatomy

- Bone physiology

- Bone adaptation to mechanical loading

- Conclusions

- References

3. Bone repair and regeneration

- Introduction

- Bone healing

- Role of stem cells in bone repair

- Molecular events of bone repair and regeneration

- Role of growth factors in bone repair and regeneration

- References

4. Biomechanical aspects of bone repair

- Bone composition and structure

- Biomechanical properties of bone

- Bone damage and repair

- Conclusions

- References

PART 2 BIOMATERIALS

5. Properties and characterisation of bone repair materials

- Introduction

- Mechanical properties

- Molecular and microstructural properties

- Physiological effects

- Comparing material classes

- Summary

- References

6. Metals as bone repair materials

- Introduction

- Common metallic biomaterials

- Other metallic materials

- Properties

- Trends in the development of metallic biomaterials

- Conclusions

- Acknowledgments

- References

Surface coating of titanium

7. Ceramics as bone repair materials

- Overview of ceramics in biomedical engineering

- Almost bioinert ceramics: first generation bioceramics

- Biodegradable and bioactive ceramics: second generation bioceramics

- Ceramics in bone regeneration: third generation ceramics

- Bioceramics today

- Acknowledgments

- References

8. Polymers for bone repair

- Introduction

- Ultra high molecular weight polyethylene (UHMWPE)

- Acrylic polymers as bone cement

- Biodegradable polymers

- Conclusions

- References

9. Composite biomaterials for bone repair

- Introduction

- Basic concept of composite material

- Composite biomaterials in bone repair

- Non-degradable composites

- Biodegradable composites

- References

10. Cements as bone repair materials

- Definition and advantages of bone cements in orthopaedic surgery

- Calcium phosphate versus acrylic bone cements: historical perspective and present applications

- Acrylic bone cements

- Calcium phosphate bone cements

- References

11. Bioactive polymer coatings to improve bone repair

- Introduction: concept of biocompatibility of biomaterials for bone repair

- Bioactive materials for bone repair

- Need for bone integration and repair biomaterials

- Available and new materials

- Bioactive polymer approach

- New approach: grafting bioactive polymers onto titanium implants

- Conclusions

- References

PART 3 CLINICAL APPLICATIONS

12. Using bone repair materials in orthopaedic surgery

- Introduction

- Operative techniques

- Materials

- Devices

- Conclusions

- References

13. Using bone repair materials in dental surgery

- Introduction

- Operative techniques

- Materials

- Devices

- Conclusions

- References

14. Using bone repair materials in spinal surgery

- Introduction

- Operative techniques

- Materials

- Devices

- Conclusions

- References

15. Using bone repair materials in maxilo-facial and skull surgery

- Introduction

- Operative techniques

- Materials

- Devices

- Conclusions

- References

16. Bone tissue engineering

- Introduction

- State-of-the-art of biomaterials for bone tissue engineering

- Cells for bone tissue engineering

- Bioactive molecules for tissue engineering

- Scaffolds for bone repair

- Bioreactors

- Clinical applications

- Conclusions

- References

Advanced manufacturing/3D printing?

17. Long-term performance and failure of orthopaedic devices

- Introduction

- Long-term failure modes

- Stress analysis, simulations and other design methodologies

- Case study 1: fatigue design in the artificial hip joint

- Case study 2: wear in ultra-high molecular weight polyethylene

- Conclusions and future trends

- References

18. Retrieval and analysis of orthopaedic implants

- Introduction

- Retrieval

- Tissue preservation

- Analysis

- Examples of results

- Acknowledgements

- References

19. Ethical issues in bone repair and bone tissue engineering

- Introduction: the ethical analysis of bone repair

- Cells in bone tissue engineered products (BTEPs)

- Clinical trials with bone tissue engineered products

- Informed consent in clinical trials

- Follow-up of trial participants

- Access to therapy

- Conclusion

- References


Description

Bone Repair Biomaterials: Regeneration and Clinical Applications, Second Edition, provides comprehensive reviews on materials science, engineering principles and recent advances. Sections review the fundamentals of bone repair and regeneration, discuss the science and properties of biomaterials used for bone repair, including metals, ceramics, polymers and composites, and discuss clinical applications and considerations, with chapters on such topics as orthopedic surgery, tissue engineering, implant retrieval, and ethics of bone repair biomaterials. This second edition includes more chapters on relevant biomaterials and a greatly expanded section on clinical applications, including bone repair applications in dental surgery, spinal surgery, and maxilo-facial and skull surgery.

In addition, the book features coverage of long-term performance and failure of orthopedic devices. It will be an invaluable resource for researchers, scientists and clinicians concerned with the repair and restoration of bone.

Key Features

  • Provides a comprehensive review of the materials science, engineering principles and recent advances in this important area
  • Presents new chapters on Surface coating of titanium, using bone repair materials in dental, spinal and maxilo-facial and skull surgery, and advanced manufacturing/3D printing
  • Reviews the fundamentals of bone repair and regeneration, addressing social, economic and clinical challenges
  • Examines the properties of biomaterials used for bone repair, with specific chapters assessing metals, ceramics, polymers and composites

Readership

Biomaterials scientists, biomedical researchers and orthopaedic clinicians concerned with bone repair, researchers and students in pharmaceutical science


Details

No. of pages:
440
Language:
English
Copyright:
© Woodhead Publishing 2019
Published:
Imprint:
Woodhead Publishing
Paperback ISBN:
9780081024515

Ratings and Reviews


About the Editors

Kendell Pawelec Editor

Dr Kendall Pawelec received her PhD from the University of Cambridge, investigating the ice templating process for tissue engineering applications. Since then, she has worked as a Marie Curie Postdoctoral Fellow, in the Netherlands, studying porous biomaterials for bone repair. Currently she is a Research Fellow at the University of Michigan, continuing to examine the impact of material structure on biological responses. She worked with the previous editors organizing the previous edition.

Affiliations and Expertise

Research Fellow, University of Michigan, USA

J. A. Planell Editor

Professor Josep A. Planell is highly regarded for his biomedical research at Universitat Politècnica de Catalunya, Spain.

Affiliations and Expertise

Institute for Bioengineering of Catalonia (IBEC), Spain

S. M. Best Editor

Dr. Serena Best is Reader in Ceramics and Medical Materials at the University of Cambridge, UK.

Affiliations and Expertise

University of Cambridge, UK

D. Lacroix Editor

Professor Damien Lacroix is highly regarded for his biomedical research at Universitat Politècnica de Catalunya, Spain.

Affiliations and Expertise

Institute for Bioengineering of Catalonia (IBEC), Spain

A. Merolli Editor

Dr. Antonio Merolli is Orthopaedic Surgeon at the Università Cattolica del Sacro Cuore, Rome, Italy and has worked extensively on in-vivo testing of biomaterials for bone repair.

Affiliations and Expertise

The Catholic University in Rome, Italy