Bone Cancer

Bone Cancer

Bone Sarcomas and Bone Metastases - From Bench to Bedside

3rd Edition - September 22, 2021
This is the Latest Edition
  • Editor: Dominique Heymann
  • Hardcover ISBN: 9780128216668
  • eBook ISBN: 9780323899901

Purchase options

Purchase options
DRM-free (PDF, EPub)
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order


Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside, Third Edition comprehensively investigates key discoveries in the field of bone biology. New aspects of bone cancer biology are treated in new chapters covering exosomes, autophagy, and metabolism. These have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches.  The Third Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with 40% new material. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases. This revision opens the door to myeloma with two short chapters dedicated to this bone-associated disease.

Key Features

  • Covers the broad field of bone sarcomas and bone metastases from basic research to clinical approaches
  • Presents comprehensive and translational overview of biological and clinical aspects of bone cancers, discussing pathophysiology from genetic and molecular levels using the most recent evidence
  • Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system
  • Offers insights to research clinicians (oncologists and radiologists) into understanding the molecular basis of bone cancer, leading to more well-informed diagnoses and treatment of tumors and metastases
  • Offers insights to bone biologists into how clinical observations and practices can feed back into the research cycle and, therefore, can contribute to the development of more targeted genomic and proteomic assays


Researchers and clinicians (oncologists, orthopaedic surgeons, pathologists, etc.) working in the field of bone related diseases and in oncology of public and private sectors. Scientific and medical students, giving an overview of the most recent knowledge of the biological and clinical features of bone cancers

Table of Contents

  • Epidemiology of Bone Cancer

    1. Osteoarchaeology: lessons to learn from the past

    2. Epidemiology of primary bone tumors and economical aspects of bone metastases

    Models of Bone Cancers and Technical Aspects

    Animal Models

    3. Animal models of bone sarcomas

    4. In vivo models used in studies of bone metastaes

    5. Zebrafish models for studying bone tumors

    Mathematic models and machine learning

    6. Use of machine learning in bone cancers

    7. Artifical intelligence for bone cancer imaging

    Preparation of tissue samples: technical aspects

    8. Technical aspects: how do we best prepare bone samples for proper histological analysis?

    Bone Microenvironment and Bone Cancer

    Bone niche

    9. Bone niche and bone metastases

    10. Bone: a fertil soil for tumor development

    11. Osteomimicry: old concepts and new findings

    Dialog between cancer cells and bone cells

    12. Role of mesenchymal stem cells in bone cancers, initiation, propagation and metastasis

    13. Technical approaches for studying the communications between osteocytes and cancer cells

    14. Osteocytes and bone cancers

    15. Immune functions of osteoclasts: new insights for bone cancers

    16. Immune infiltrate in bone sarcomas

    17. Macrophages and pathophysiology of bone cancers

    Mediators of cell communications

    18. Growth factors, cytokines and pediatric malignant primary bones tumors

    19. The role of NFkB in bone cancer

    20. TGF-beta and bone cancers: a specific focus

    21. Extracellular vesicles, tumor growth and metastatic process

    22. Connexin43 and development of primary bone tumors : osteosarcoma and Ewing’s sarcoma

    23. The role of endocannabinoid system in bone cancer


    24. Impact of the microenvironment acidosis on bone cancers

    25. Hypoxic niche and bone cancers

    26. Metabolism and bone cancers

    Bone Tumor Heterogeneity, Plasticity and Biomarkers

    Heterogeneity and plasticity

    27. EMT process in bone metastasis

    28. Cancer stem cells and clonal evolution in bone sarcomas

    29. Dormancy in cancer bone metastasis


    30. Bone Remodelling Markers and Bone Cancer

    31. Epigenetic Heterogeneity in Primary Bone Cancers

    32. miRNA implication in therapeutic resistance and metastatic dissemination of bone-associated tumors

    33. MicroRNAs and bone metastasis: how small RNAs regulate secondary tumour formation and progression in the skeleton

    34. Long-non coding RNA and bone sarcoma

    35. Liquid biopsy and circulating tumor cells in bone sarcomas: identification of new biomarkers and analysis of the tumor heterogeneity

    36. Disseminated tumor cells in bone marrow of cancer patients


    Biological aspects

    37. Cytogenetics of bone sarcomas

    38. Genetic aspects of primary bone tumors

    39. Markers of bone sarcomas

    40. Molecular pathology of osteosarcoma

    41. Genomic and proteomic profiling of osteosarcoma

    42. Ewing sarcoma family of tumors

    43. Molecular aspects of Ewing sarcomas

    44. Osteoclast-rich lesions: a clinical and molecular overview

    45. Biology of cartilage tumor family

    Clinical aspects and Perspectives


    46. Imaging of bone sarcomas

    Therapeutic approaches

    47. Current therapeutic approaches of bone sarcomas

    48. Surgical approaches of bone sarcomas: Margins and clinical impact

    49. Apoptosis and drug resistance in malignant bone tumors: impact on the clinical practices

    50. Chondrosarcoma of Bone: Diagnosis and Therapy

    51. Radiotherapy and Primary bone tumors

    52. New therapeutic advances of bone sarcomas


    Biological aspects

    53. The histopathology of skeletal Metastases

    54. Indentification of new therapeutic targets of bone cancers by proteomic strategies

    Clinical aspects and Perspectives


    55. Interventional radiologic techniques in management of bone tumors

    56. Diagnosis of bone metastases in urological malignancies – an update

    Bone pain

    57. Mechanisms and management of bone cancer pain

    58. Involvement of sympathic nerves in bone mestastasis

    59. Pain control with palliative radiotherapy in patients with bone metastases

    60. Palliative care of bone metastases

    Therapeutic approaches

    61. Radiotherapy of bone metastases

    62. Cellular and molecular actions of bisphosphonates: therapeutic interest in tumor-associated bone diseases

    63. Bone-Targeted agents and skeletal-related events in breast cancer patients with bone metastases

    64. Bone metastases – current status of bone-targeted treatments

    65. Therapies of bone metastases in castration-resistant prostate cancer

    66. Therapy with bone-targeting radiopharmaceuticals

    67. Therapeutic approaches of bone metastases associated with breast cancer


    68. Biological relationship between bone and myeloma cells

    69. Recent therapeutic approaches in myeloma

Product details

  • No. of pages: 1078
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: September 22, 2021
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128216668
  • eBook ISBN: 9780323899901
  • About the Editor

    Dominique Heymann

    Dominique Heymann
    Dominique Heymann studied cell biology, biochemistry and immunology in INSERM (French NIH) unit 211 at the University of Nantes and received his Ph.D. in 1995. He was appointed Associate Professor in 2001 in the Department of Histology and Embryology. In 2009, he was awarded a personal Chair of Histology and Embryology.

    Currently he is the Quality Control Manager of the Tissue Bank and Gene and Cellular Therapy Unit at Nantes Hospital. He heads a laboratory research group (INSERM UMR 957) of 65 people at the Faculty of Medicine, where the pathogenesis of primary bone tumours, and more specifically, the role of bone microenvironment (osteoclasts, mesenchymal stem cells, OPG/RANK/RANKL, IL-6 and MCSF cytokine family) in tumour growth is studied.

    In 2006, Dominique Heymann won the Paul Mathieu prize from the National Academy of Medicine for his work entitled “From the osteolytic process associated to primary bone tumors to the development of bi-therapies for osteosarcoma”. He was on the national scientific advisory board of INSERM (2008-2012) and is now Co-Chairman of INSERM scientific commission n°5 (“Physiology and pathophysiology of endocrine, bone, skin and gastrointestinal tissues”). He has authored approximately 180 publications in peer- reviewed journals, more than 300 abstracts and 20 book chapters. He is also Associate Editor of Life Sciences, Academic Editor of PLoS ONE, Editor-in-Chief of the Open Bone Journal and serves on the Editorial Board of Current Medicine Chemistry, European Journal of Pharmacology, and Journal of Bone Oncology.

    Affiliations and Expertise

    Professor, Faculty of Medicine, University of Nantes; Head of Pathophysiology of Bone Resorption and Therapy of Primitive Bone Tumors, INSERM, Nantes, France