Bone Cancer

Bone Cancer

Progression and Therapeutic Approaches

1st Edition - August 20, 2009

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  • Editor: Dominique Heymann
  • eBook ISBN: 9780080953885

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The epidemiological and clinical importance of bone metastasis has long been recognized, but the past decade has seen an explosion in the fields of bone biology and bone cancer research. This period of time has been marked by a number of key discoveries that have led to the opening up of entirely new areas for investigation as well as new therapies which combine surgery and biological therapeutic approaches.Bone is a common site of cancer metastases - cancer cells commonly develop in bone and spread to other organ systems through the bloodstream. For example, the incidence of bone metastases in breast and prostate cancers is 70%, whereas it is only 30 to 40% in metastatic lung cancer. In clinical terms, bone metastases have substantial negative effects on a patient's quality of life and are a main cause of patient mortality. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for the medical and cancer research communities. This book provides, all in one resource, the most recent data on bone cancer development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases.

Key Features


  • Presents a comprehensive, translational source for all aspects of bone cancer in one reference work
  • Bone cancer experts (from all areas of research and practice) take readers from the bench research (cellular and molecular mechanism), through genomic and proteomic analysis, all the way to clinical analysis (histopathology and imaging) and new therapeutic approaches.
  • Clear presentation by bone biologists of the cellular and molecular mechanisms underlying bone tumors and bone cancer metastasis as well as the genomic and proteomic assays used in detecting cancer within given organ systems
  • Clear presentation by oncologists and radiologists of how histopathology, imaging, and pain monitoring can lead to new therapeutic approaches
  • Benefit

  • Saves researchers and clinicians time in quickly accessing the very latest details on a broad range of bone cancer issues, as opposed to searching through thousands of journal articles.

  • Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system
  • Correct diagnosis (and therefore correct treatment) of cancer depends on a strong understanding of the molecular basis for the disease – both oncologists and radiologists will benefit
  • Bone biologists will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic and proteomic assays


Bone biologists, cancer researchers, oncologists, orthopedic surgeons, radiologists and other specialists in cancer imaging, Medical libraries, graduate academic libraries

Table of Contents

  • Section 1: Genetic Control, Frequencies and Epidemiology of Bone Caner
    1. Epidemiology of Primary Bone Tumors and Economical Aspects of Bone Metastases
    Esther I. Hauben and Pancras C.W. Hogendoorn

    Section 2: Bone Microenvironment and Bone Cancer
    2. Tumor-Bone Cell Interactions in Bone Metastases
    Pierrick G.J. Fournier, Lauren K. Dunn, Gregory A. Clines, Theresa A. Guise
    3. Early Bone Metastasis-Associated Molecular and Cellular Events
    Philippe Clezardin
    4. Regulation of Osteoblast Differentiation and Bone Cancers by Wnt and Parathyroid Hormone Signaling Pathways
    Julia Billiard, John A. Robinson, Ramesh A. Bhat, Bheem M. Bhat, Richard Murrills and Peter V.N. Bodine
    5. Osteoclast Differentiation and Function
    Luis Filgueira
    6. Immunoregulation of Osteoclast Differentiation in Multiple Myeloma Bone Diseases
    Maria Grano, Giacomina Brunetti and Silvia Colucci
    7. Facts and Hypothesis on Osteolytic Lesions Related to Normal and Tumoral Epithelial Dental Cell Differentiation
    Blandine Ruhin, Frederic Lezot, Aymann Bouattour, Sonia Ghoul-Mazghar, Ariane Berdal, Vianney Descroix
    8. The Role of the Interleukin-6 Family of Cytokines in Bone Remodeling and Bone Cancer
    Frederic Blanchard, Emmanuelle David, Bénédicte Brounais
    9. Proteases and Therapeutic Approaches of Bone Tumors
    Velasco C. Ruiz, Y. Fortun, Dominique Heymann, Marc Padrines

    Section 3: and Bone Markers of Cancer (genes and proteins)
    10.Bone Remodelling Markers and Bone Cancer
    Markus J. Seibel
    11. Cytogenetic and Molecular Genetic Alterations in Bone Tumors
    Suvi Savola, Tom Böhling, Sakari Knuutila
    12. Cytogenetic of Bone Tumors
    Jiyun Lee, Mallory Martin, Shibo Li
    13. Genetic Aspects of Bone Tumors
    Shamini Selvarajah, Maria Zielenska, Jeremy A. Squire, Paul Park
    14. Proteomic of Bone Cancers
    Stephanie Byrum, Eric Siegel, Sudeepa Bhattacharyya, Larry J Suva
    15. Gene and proteomic profiling of osteosarcoma
    Tsz-Kwong Man, Pulivarthi H. Rao, Ching C. Lau
    16. Molecular Pathology of Osteosarcoma
    Walter C. Bell, Gene P. Siegal

    Section 4: Histopathology of Primary Bone Tumors and Bone Metastases
    17. Technical Aspects: How Do We Best Prepare Bone Samples for Proper Histological Analysis?
    Daniel Chappard
    18. Osteoclast-Rich Lesions of Bone: A Clinical and Molecular Overview
    Adrienne Flanagan, Roberto Tirabosco, Panagiotis D. Gikas
    19. Recent Advances in Biology of Bone Tumors and New Diagnostic Tools
    Gonzague de Pinieux, Corinne Bouvier
    20. Ewing Sarcoma Family of Tumors
    Joseph D. Khoury
    21. The Histopathology of Skeletal Metastases
    David G. Hicks, Ping Tang

    Section 5: Imaging of Bone Cancer
    22. Interventional Radiologic Techniques and their Contribution of the Management of Bone Tumors
    Robert G. Jones, Eric J. Heffernan, Faisal Rashid, Peter L. Munk
    23. Imaging of Bone Metastases
    Nieroshan Rajaurbendra, Nathan Lawrentschuk
    24. Diagnosis of Skeletal Metastases in Malignant Extraskeletal Cancers
    Holger Schirrmeister, Coskun Arslandemir

    Section 6: Pain Control in Bone Cancer
    25. Pain Control with Palliative Radiotherapy in Bone Metastases
    Alysa Fairchild, Amanda Hird, Edward Chow
    26. Mechanisms and Management of Bone Cancer Pain
    Mary Ann C. Sabino, Denis R. Clohisy
    27. Malignant Skeletal Pain: Mechanisms and Potential Therapeutic Opportunities
    Monica Herrera, Juan Miguel Jimenez-Andrade, Marina Vardanyan, Patrick Mantyh

    Section 8: New Therapeutic Advance in Primary Bone Cancers and Bone Metastases
    28. Animal Models of Malignant Primary Bone Tumors and Novel Therapeutic Approaches
    Julie Rousseau, François Lamoureux, Gaelle Picarda, François Gouin, Valérie Trichet, Françoise Rédini
    29. In Vivo Models Used in Studies of Bone Metastases
    Ingunn Holen, Michele A. Lawson
    30. Cytokine Gene Therapy in Bone Remodeling
    Carl Richards, David Smyth
    31. Non-Surgical Treatment of Chondrosarcoma: Current Concepts and Future Perspectives
    Eric L. Staals, Emanuela Palmerini, Stefano Ferrari, and Mario Mercuri
    32. Mechanistic Role of RANKL in Cancer Induced Bone Diseases and Development of Targeted Therapy to Inhibit this Pathway
    William C. Dougall
    33. Chondrosarcoma of Bone: Diagnosis and Therapy
    Arne Steitbueger, Jendrik Hardes, Georg Gosheger
    34. Current Status of Immunotherapy for Osteosarcoma and its Future Trends
    Kanji Mori, Kosei Ando, Yoshitaka Matsusue, Dominique Heymann
    35. Bisphosphonates, Bone Health and the Clinical Biology of Bone Metastases from Breast Cancer
    Alexander Paterson
    36. A Multi-Targeted Approach to Treating Bone Metastases
    Robert D. Loberg, Kenneth J. Pienta
    37. Bone Metasteses of Prostatic Cancer: Pathophysiology, Clinical Complications, Actual Treatment and Future Directions
    Sara De Dosso, Fernanda G. Herrera, Dominik R. Berthold
    38. Apoptosis and Drug Resistance in Malignant Bone Tumors
    Udo Kontny

Product details

  • No. of pages: 504
  • Language: English
  • Copyright: © Academic Press 2009
  • Published: August 20, 2009
  • Imprint: Academic Press
  • eBook ISBN: 9780080953885

About the Editor

Dominique Heymann

Dominique Heymann
Dominique Heymann studied cell biology, biochemistry and immunology in INSERM (French NIH) unit 211 at the University of Nantes and received his Ph.D. in 1995. He was appointed Associate Professor in 2001 in the Department of Histology and Embryology. In 2009, he was awarded a personal Chair of Histology and Embryology.

Currently he is the Quality Control Manager of the Tissue Bank and Gene and Cellular Therapy Unit at Nantes Hospital. He heads a laboratory research group (INSERM UMR 957) of 65 people at the Faculty of Medicine, where the pathogenesis of primary bone tumours, and more specifically, the role of bone microenvironment (osteoclasts, mesenchymal stem cells, OPG/RANK/RANKL, IL-6 and MCSF cytokine family) in tumour growth is studied.

In 2006, Dominique Heymann won the Paul Mathieu prize from the National Academy of Medicine for his work entitled “From the osteolytic process associated to primary bone tumors to the development of bi-therapies for osteosarcoma”. He was on the national scientific advisory board of INSERM (2008-2012) and is now Co-Chairman of INSERM scientific commission n°5 (“Physiology and pathophysiology of endocrine, bone, skin and gastrointestinal tissues”). He has authored approximately 180 publications in peer- reviewed journals, more than 300 abstracts and 20 book chapters. He is also Associate Editor of Life Sciences, Academic Editor of PLoS ONE, Editor-in-Chief of the Open Bone Journal and serves on the Editorial Board of Current Medicine Chemistry, European Journal of Pharmacology, and Journal of Bone Oncology.

Affiliations and Expertise

Professor, Faculty of Medicine, University of Nantes; Head of Pathophysiology of Bone Resorption and Therapy of Primitive Bone Tumors, INSERM, Nantes, France

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